BIOMAT Database Logo BIOMAT Database Logo

Adult acute lymphoblastic leukemia: concepts and strategies. 2010

Stefan Faderl, and Susan O'Brien, and Ching-Hon Pui, and Wendy Stock, and Meir Wetzler, and Dieter Hoelzer, and Hagop M Kantarjian
Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA. sfaderl@mdanderson.org

Acute lymphoblastic leukemia (ALL), a clonal expansion of hematopoietic blasts, is a highly heterogeneous disease comprising many entities for which distinct treatment strategies are pursued. Although ALL is a success story in pediatric oncology, results in adults lag behind those in children. An expansion of new drugs, more reliable immunologic and molecular techniques for the assessment of minimal residual disease, and efforts at more precise risk stratification are generating new aspects of adult ALL therapy. For this review, the authors summarized pertinent and recent literature on ALL biology and therapy, and they discuss current strategies and potential implications of novel approaches to the management of adult ALL. Cancer 2010. (c) 2010 American Cancer Society.

UI MeSH Term Description Entries
D010677 Philadelphia Chromosome An aberrant form of human CHROMOSOME 22 characterized by translocation of the distal end of chromosome 9 from 9q34, to the long arm of chromosome 22 at 22q11. It is present in the bone marrow cells of 80 to 90 per cent of patients with chronic myelocytic leukemia (LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE). Ph1 Chromosome,Ph 1 Chromosome,1 Chromosomes, Ph,Chromosome, Ph 1,Chromosome, Ph1,Chromosome, Philadelphia,Chromosomes, Ph 1,Chromosomes, Ph1,Ph 1 Chromosomes,Ph1 Chromosomes
D011379 Prognosis A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations. Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D012008 Recurrence The return of a sign, symptom, or disease after a remission. Recrudescence,Relapse,Recrudescences,Recurrences,Relapses
D002869 Chromosome Aberrations Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS. Autosome Abnormalities,Cytogenetic Aberrations,Abnormalities, Autosome,Abnormalities, Chromosomal,Abnormalities, Chromosome,Chromosomal Aberrations,Chromosome Abnormalities,Cytogenetic Abnormalities,Aberration, Chromosomal,Aberration, Chromosome,Aberration, Cytogenetic,Aberrations, Chromosomal,Aberrations, Chromosome,Aberrations, Cytogenetic,Abnormalities, Cytogenetic,Abnormality, Autosome,Abnormality, Chromosomal,Abnormality, Chromosome,Abnormality, Cytogenetic,Autosome Abnormality,Chromosomal Aberration,Chromosomal Abnormalities,Chromosomal Abnormality,Chromosome Aberration,Chromosome Abnormality,Cytogenetic Aberration,Cytogenetic Abnormality
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias. Leukemia, Lymphoblastic,Leukemia, Lymphoid, Acute,Lymphoblastic Leukemia,Lymphoblastic Lymphoma,Lymphocytic Leukemia, Acute,Lymphoma, Lymphoblastic,ALL, Childhood,Acute Lymphoid Leukemia,Leukemia, Acute Lymphoblastic,Leukemia, Lymphoblastic, Acute,Leukemia, Lymphoblastic, Acute, L1,Leukemia, Lymphoblastic, Acute, L2,Leukemia, Lymphoblastic, Acute, Philadelphia-Positive,Leukemia, Lymphocytic, Acute,Leukemia, Lymphocytic, Acute, L1,Leukemia, Lymphocytic, Acute, L2,Lymphoblastic Leukemia, Acute,Lymphoblastic Leukemia, Acute, Adult,Lymphoblastic Leukemia, Acute, Childhood,Lymphoblastic Leukemia, Acute, L1,Lymphoblastic Leukemia, Acute, L2,Lymphocytic Leukemia, L1,Lymphocytic Leukemia, L2,Acute Lymphoblastic Leukemia,Acute Lymphocytic Leukemia,Childhood ALL,L1 Lymphocytic Leukemia,L2 Lymphocytic Leukemia,Leukemia, Acute Lymphocytic,Leukemia, Acute Lymphoid,Leukemia, L1 Lymphocytic,Leukemia, L2 Lymphocytic,Lymphoid Leukemia, Acute,Precursor Cell Lymphoblastic Leukemia Lymphoma
D018380 Hematopoietic Stem Cell Transplantation Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms. Stem Cell Transplantation, Hematopoietic,Transplantation, Hematopoietic Stem Cell

Related Publications

Stefan Faderl, and Susan O'Brien, and Ching-Hon Pui, and Wendy Stock, and Meir Wetzler, and Dieter Hoelzer, and Hagop M Kantarjian
Current therapeutic strategies in adult acute lymphoblastic leukemia.
December 2011, Hematology/oncology clinics of North America,
Stefan Faderl, and Susan O'Brien, and Ching-Hon Pui, and Wendy Stock, and Meir Wetzler, and Dieter Hoelzer, and Hagop M Kantarjian
[Adult acute lymphoblastic leukemia].
May 2011, La Revue du praticien,
Stefan Faderl, and Susan O'Brien, and Ching-Hon Pui, and Wendy Stock, and Meir Wetzler, and Dieter Hoelzer, and Hagop M Kantarjian
Adult Acute Lymphoblastic Leukemia.
November 2016, Mayo Clinic proceedings,
Stefan Faderl, and Susan O'Brien, and Ching-Hon Pui, and Wendy Stock, and Meir Wetzler, and Dieter Hoelzer, and Hagop M Kantarjian
Adult acute lymphoblastic leukemia.
November 2005, Mayo Clinic proceedings,
Stefan Faderl, and Susan O'Brien, and Ching-Hon Pui, and Wendy Stock, and Meir Wetzler, and Dieter Hoelzer, and Hagop M Kantarjian
Adult acute lymphoblastic leukemia.
September 2004, JPMA. The Journal of the Pakistan Medical Association,
Stefan Faderl, and Susan O'Brien, and Ching-Hon Pui, and Wendy Stock, and Meir Wetzler, and Dieter Hoelzer, and Hagop M Kantarjian
[Current therapeutic strategies in acute lymphoblastic leukemia in the adult].
October 2003, Bulletin du cancer,
Stefan Faderl, and Susan O'Brien, and Ching-Hon Pui, and Wendy Stock, and Meir Wetzler, and Dieter Hoelzer, and Hagop M Kantarjian
[Reappraisal of the treatment strategies for adult acute lymphoblastic leukemia].
February 2014, Zhonghua nei ke za zhi,
Stefan Faderl, and Susan O'Brien, and Ching-Hon Pui, and Wendy Stock, and Meir Wetzler, and Dieter Hoelzer, and Hagop M Kantarjian
Acute lymphoblastic leukemia: current treatment concepts.
April 2000, Indian pediatrics,
Stefan Faderl, and Susan O'Brien, and Ching-Hon Pui, and Wendy Stock, and Meir Wetzler, and Dieter Hoelzer, and Hagop M Kantarjian
Adult Ph-positive acute lymphoblastic leukemia-current concepts in cytogenetic abnormalities and outcomes.
January 2020, American journal of cancer research,
Stefan Faderl, and Susan O'Brien, and Ching-Hon Pui, and Wendy Stock, and Meir Wetzler, and Dieter Hoelzer, and Hagop M Kantarjian
Current treatment strategies for Philadelphia chromosome-positive adult acute lymphoblastic leukemia.
July 2020, Blood research,
Copied contents to your clipboard!