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The proteins released in vitro by metabolically radiolabeled adult Schistosoma mansoni were identified by 2-dimensional gel electrophoresis. To determine the origin of these proteins, adult worms were fractionated into surface membrane, tegument, and remaining body components, and the electrophoretic patterns of the proteins in the 3 fractions were compared to those of the released proteins. The immunogens present in these fractions then were identified by immunoprecipitation with sera from humans infected with S. mansoni. This analysis indicated that essentially all of the proteins released from the worm were immunogenic, whereas most of the major membrane and tegumental proteins were not reactive with the immune sera. Thus, it appears that the adult worm is defended against immune attack by detection of the host's antibody response against released proteins rather than against proteins-exposed on the worm's surface.
S A Lewis, and
M Strand
January 1990,
Molecular and biochemical parasitology,
S A Lewis, and
M Strand
June 1987,
Acta tropica. Supplementum,
S A Lewis, and
M Strand
January 1977,
Annales d'immunologie,
S A Lewis, and
M Strand
October 2000,
Parasitology,
S A Lewis, and
M Strand
June 1999,
Parasitology,
S A Lewis, and
M Strand
May 1990,
International journal for parasitology,
S A Lewis, and
M Strand
October 1985,
Experimental parasitology,
S A Lewis, and
M Strand
September 2019,
Parasites & vectors,
S A Lewis, and
M Strand
March 1992,
The Journal of biological chemistry,
S A Lewis, and
M Strand
January 1991,
Memorias do Instituto Oswaldo Cruz,
