Increased hippocampal head diffusivity predicts impaired episodic memory performance in early Alzheimer's disease. 2010

Igor Yakushev, and Matthias J Müller, and Markus Lorscheider, and Ingrid Schermuly, and Carsten Weibrich, and Paulo R Dellani, and Alexander Hammers, and Peter Stoeter, and Andreas Fellgiebel
Department of Psychiatry and Psychotherapy, University of Mainz, Mainz, Germany.

Recent neuroanatomical and functional neuroimaging studies indicate that the anterior part of the hippocampus, rather than the whole structure, may be specifically involved in episodic memory. In the present work, we examined whether anterior structural measurements are superior to other regional or global measurements in mapping functionally relevant degenerative alterations of the hippocampus in Alzheimer's disease (AD). Twenty patients with early AD (MMSE 25.7+/-1.7) and 18 healthy controls were studied using magnetic resonance and diffusion-tensor imaging. Using a regions-of-interest analysis, we obtained volumetric and diffusivity measures of the hippocampal head and body-tail-section as well as of the whole hippocampus. Detailed cognitive evaluation was based on the CERAD battery. All volumetric measures as well as diffusivity of the hippocampus head were significantly (p<0.01) altered in patients as compared to controls. In patients, increased left head diffusivity significantly (p<0.01) correlated with performance on free delayed verbal recall test (DVR) (r=-0.74, p=0.0002) and with the CERAD global score. Reduced volume of the left body-tail was also associated with performance on DVR (r=0.62, p=0.004). Stepwise regression analyses revealed that increased left head diffusivity was the only predictor for performance on DVR (R(2)=52%, p<0.0005). These findings suggest that anterior hippocampus diffusivity is more closely related to verbal episodic memory impairment than other regional or global structural measures. Our data support the hypothesis of functional differentiation in general and the specific role of the anterior hippocampus in episodic memory in particular. Diffusivity measurements might be highly sensitive to functionally relevant degenerative alterations of the hippocampus.

UI MeSH Term Description Entries
D008279 Magnetic Resonance Imaging Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques. Chemical Shift Imaging,MR Tomography,MRI Scans,MRI, Functional,Magnetic Resonance Image,Magnetic Resonance Imaging, Functional,Magnetization Transfer Contrast Imaging,NMR Imaging,NMR Tomography,Tomography, NMR,Tomography, Proton Spin,fMRI,Functional Magnetic Resonance Imaging,Imaging, Chemical Shift,Proton Spin Tomography,Spin Echo Imaging,Steady-State Free Precession MRI,Tomography, MR,Zeugmatography,Chemical Shift Imagings,Echo Imaging, Spin,Echo Imagings, Spin,Functional MRI,Functional MRIs,Image, Magnetic Resonance,Imaging, Magnetic Resonance,Imaging, NMR,Imaging, Spin Echo,Imagings, Chemical Shift,Imagings, Spin Echo,MRI Scan,MRIs, Functional,Magnetic Resonance Images,Resonance Image, Magnetic,Scan, MRI,Scans, MRI,Shift Imaging, Chemical,Shift Imagings, Chemical,Spin Echo Imagings,Steady State Free Precession MRI
D008297 Male Males
D008569 Memory Disorders Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory impairments are associated with DEMENTIA; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; ALCOHOLISM (see also ALCOHOL AMNESTIC DISORDER); SCHIZOPHRENIA; and other conditions. Memory Loss,Age-Related Memory Disorders,Memory Deficits,Memory Disorder, Semantic,Memory Disorder, Spatial,Memory Disorders, Age-Related,Retention Disorders, Cognitive,Semantic Memory Disorder,Spatial Memory Disorder,Age Related Memory Disorders,Age-Related Memory Disorder,Cognitive Retention Disorder,Cognitive Retention Disorders,Deficit, Memory,Deficits, Memory,Memory Deficit,Memory Disorder,Memory Disorder, Age-Related,Memory Disorders, Age Related,Memory Disorders, Semantic,Memory Disorders, Spatial,Memory Losses,Retention Disorder, Cognitive,Semantic Memory Disorders,Spatial Memory Disorders
D011237 Predictive Value of Tests In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test. Negative Predictive Value,Positive Predictive Value,Predictive Value Of Test,Predictive Values Of Tests,Negative Predictive Values,Positive Predictive Values,Predictive Value, Negative,Predictive Value, Positive
D011939 Mental Recall The process whereby a representation of past experience is elicited. Recall, Mental
D005260 Female Females
D006624 Hippocampus A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation. Ammon Horn,Cornu Ammonis,Hippocampal Formation,Subiculum,Ammon's Horn,Hippocampus Proper,Ammons Horn,Formation, Hippocampal,Formations, Hippocampal,Hippocampal Formations,Hippocampus Propers,Horn, Ammon,Horn, Ammon's,Proper, Hippocampus,Propers, Hippocampus,Subiculums
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D000544 Alzheimer Disease A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57) Acute Confusional Senile Dementia,Alzheimer's Diseases,Dementia, Alzheimer Type,Dementia, Senile,Presenile Alzheimer Dementia,Senile Dementia, Alzheimer Type,Alzheimer Dementia,Alzheimer Disease, Early Onset,Alzheimer Disease, Late Onset,Alzheimer Sclerosis,Alzheimer Syndrome,Alzheimer Type Senile Dementia,Alzheimer's Disease,Alzheimer's Disease, Focal Onset,Alzheimer-Type Dementia (ATD),Dementia, Presenile,Dementia, Primary Senile Degenerative,Early Onset Alzheimer Disease,Familial Alzheimer Disease (FAD),Focal Onset Alzheimer's Disease,Late Onset Alzheimer Disease,Primary Senile Degenerative Dementia,Senile Dementia, Acute Confusional,Alzheimer Dementias,Alzheimer Disease, Familial (FAD),Alzheimer Diseases,Alzheimer Type Dementia,Alzheimer Type Dementia (ATD),Alzheimers Diseases,Dementia, Alzheimer,Dementia, Alzheimer-Type (ATD),Familial Alzheimer Diseases (FAD),Presenile Dementia,Sclerosis, Alzheimer,Senile Dementia

Related Publications

Igor Yakushev, and Matthias J Müller, and Markus Lorscheider, and Ingrid Schermuly, and Carsten Weibrich, and Paulo R Dellani, and Alexander Hammers, and Peter Stoeter, and Andreas Fellgiebel
May 2008, Revue neurologique,
Igor Yakushev, and Matthias J Müller, and Markus Lorscheider, and Ingrid Schermuly, and Carsten Weibrich, and Paulo R Dellani, and Alexander Hammers, and Peter Stoeter, and Andreas Fellgiebel
January 2019, NeuroImage. Clinical,
Igor Yakushev, and Matthias J Müller, and Markus Lorscheider, and Ingrid Schermuly, and Carsten Weibrich, and Paulo R Dellani, and Alexander Hammers, and Peter Stoeter, and Andreas Fellgiebel
August 2016, Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference,
Igor Yakushev, and Matthias J Müller, and Markus Lorscheider, and Ingrid Schermuly, and Carsten Weibrich, and Paulo R Dellani, and Alexander Hammers, and Peter Stoeter, and Andreas Fellgiebel
January 1995, Journal of the International Neuropsychological Society : JINS,
Igor Yakushev, and Matthias J Müller, and Markus Lorscheider, and Ingrid Schermuly, and Carsten Weibrich, and Paulo R Dellani, and Alexander Hammers, and Peter Stoeter, and Andreas Fellgiebel
March 2023, Disease models & mechanisms,
Igor Yakushev, and Matthias J Müller, and Markus Lorscheider, and Ingrid Schermuly, and Carsten Weibrich, and Paulo R Dellani, and Alexander Hammers, and Peter Stoeter, and Andreas Fellgiebel
January 2020, Journal of Alzheimer's disease : JAD,
Igor Yakushev, and Matthias J Müller, and Markus Lorscheider, and Ingrid Schermuly, and Carsten Weibrich, and Paulo R Dellani, and Alexander Hammers, and Peter Stoeter, and Andreas Fellgiebel
September 2021, Experimental brain research,
Igor Yakushev, and Matthias J Müller, and Markus Lorscheider, and Ingrid Schermuly, and Carsten Weibrich, and Paulo R Dellani, and Alexander Hammers, and Peter Stoeter, and Andreas Fellgiebel
January 2015, Frontiers in genetics,
Igor Yakushev, and Matthias J Müller, and Markus Lorscheider, and Ingrid Schermuly, and Carsten Weibrich, and Paulo R Dellani, and Alexander Hammers, and Peter Stoeter, and Andreas Fellgiebel
November 1991, Brain and language,
Igor Yakushev, and Matthias J Müller, and Markus Lorscheider, and Ingrid Schermuly, and Carsten Weibrich, and Paulo R Dellani, and Alexander Hammers, and Peter Stoeter, and Andreas Fellgiebel
September 2010, Memory & cognition,
Copied contents to your clipboard!