Metabolism of the Neonicotinoid insecticides acetamiprid and thiacloprid by the yeast Rhodotorula mucilaginosa strain IM-2. 2010

Yi-Jun Dai, and Wei-Wei Ji, and Ting Chen, and Wen-Jian Zhang, and Zhong-Hua Liu, and Feng Ge, and Sheng Yuan
Jiangsu Engineering and Technology Research Center for Industrialization of Microbial Resources, College of Life Science, Nanjing Normal University, Nanjing 210046, People's Republic of China.

A yeast identified as Rhodotorula mucilaginosa strain IM-2 was able to degrade acetamiprid (AAP) and thiacloprid (THI) in sucrose mineral salt medium with half-lives of 3.7 and 14.8 days, respectively, while it did not degrade imidacloprid and imidaclothiz. Identification of metabolites indicated that R. mucilaginosa IM-2 selectively converted AAP and THI by hydrolysis of AAP to form an intermediate metabolite IM 1-3 and hydrolysis of THI to form an amide derivative, respectively. Metabolite IM 1-3 had no insecticidal activity, while the THI amide showed considerable insecticidal activity but was 15.6 and 38.6 times lower than the parent THI following oral ingestion and a contact test against the horsebean aphid Aphis craccivora , respectively. The inoculated R. mucilaginosa IM-2 displayed biodegradability of AAP and THI in clay soils.

UI MeSH Term Description Entries
D007306 Insecticides Pesticides designed to control insects that are harmful to man. The insects may be directly harmful, as those acting as disease vectors, or indirectly harmful, as destroyers of crops, food products, or textile fabrics. Insecticide
D009682 Magnetic Resonance Spectroscopy Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING). In Vivo NMR Spectroscopy,MR Spectroscopy,Magnetic Resonance,NMR Spectroscopy,NMR Spectroscopy, In Vivo,Nuclear Magnetic Resonance,Spectroscopy, Magnetic Resonance,Spectroscopy, NMR,Spectroscopy, Nuclear Magnetic Resonance,Magnetic Resonance Spectroscopies,Magnetic Resonance, Nuclear,NMR Spectroscopies,Resonance Spectroscopy, Magnetic,Resonance, Magnetic,Resonance, Nuclear Magnetic,Spectroscopies, NMR,Spectroscopy, MR
D011725 Pyridines Compounds with a six membered aromatic ring containing NITROGEN. The saturated version is PIPERIDINES.
D002455 Cell Division The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION. M Phase,Cell Division Phase,Cell Divisions,Division Phase, Cell,Division, Cell,Divisions, Cell,M Phases,Phase, Cell Division,Phase, M,Phases, M
D002853 Chromatography, Liquid Chromatographic techniques in which the mobile phase is a liquid. Liquid Chromatography
D006868 Hydrolysis The process of cleaving a chemical compound by the addition of a molecule of water.
D000073943 Neonicotinoids A class of insecticides that are structurally similar to NICOTINE and have physiologically similar effects as agonists of NICOTINIC ACETYLCHOLINE RECEPTORS, but are less toxic to vertebrates. They are widely used in agriculture. Neonicotinoid
D012248 Rhodotorula A red yeast-like mitosporic fungal genus generally regarded as nonpathogenic. It is cultured from numerous sources in human patients. Rhodotorulas
D012987 Soil The unconsolidated mineral or organic matter on the surface of the earth that serves as a natural medium for the growth of land plants. Peat,Humus,Soils
D013058 Mass Spectrometry An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers. Mass Spectroscopy,Spectrometry, Mass,Spectroscopy, Mass,Spectrum Analysis, Mass,Analysis, Mass Spectrum,Mass Spectrum Analysis,Analyses, Mass Spectrum,Mass Spectrum Analyses,Spectrum Analyses, Mass

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