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In this study, we evaluated a simplified rapid 14C-urea breath test for the diagnosis of Helicobacter pylori. Fasting patients undergoing initial assessment for H. pylori drank 5 microCi of 14C-urea in 20 ml of water. Breath was collected at intervals for 30 min. Samples were counted in a beta-counter, and the results were expressed as counts per minute (cpm). In the same week, patients underwent endoscopy, and a blinded investigator examined biopsy samples of gastric mucosa by culture and histology for H. pylori. There were 49 H. pylori-negative (HP-) and 104 H. pylori-positive (HP+) patients in the study. HP+ patients expired a mean of 4398 cpm (SD 2468) per mmol CO2 in a sample taken 20 min after ingestion of the isotope. In contrast, HP--patients expired only 340 cpm (SD 196). If the mean +3 SD of HP- patients was used as a cutoff value, the 20-minute sample gave a sensitivity of 97% and a specificity of 100% for detecting H. pylori. The radiation exposure from this test is less than 1% of that received from an upper gastrointestinal series, and the short collection time makes it both convenient and cost effective.
B J Marshall, and
M W Plankey, and
S R Hoffman, and
C L Boyd, and
K R Dye, and
H F Frierson, and
R L Guerrant, and
R W McCallum
January 1998,
Irish medical journal,
B J Marshall, and
M W Plankey, and
S R Hoffman, and
C L Boyd, and
K R Dye, and
H F Frierson, and
R L Guerrant, and
R W McCallum
December 2006,
Canadian journal of gastroenterology = Journal canadien de gastroenterologie,
B J Marshall, and
M W Plankey, and
S R Hoffman, and
C L Boyd, and
K R Dye, and
H F Frierson, and
R L Guerrant, and
R W McCallum
January 1998,
Journal of gastroenterology,
B J Marshall, and
M W Plankey, and
S R Hoffman, and
C L Boyd, and
K R Dye, and
H F Frierson, and
R L Guerrant, and
R W McCallum
January 1991,
Digestion,
B J Marshall, and
M W Plankey, and
S R Hoffman, and
C L Boyd, and
K R Dye, and
H F Frierson, and
R L Guerrant, and
R W McCallum
June 1994,
Gut,
B J Marshall, and
M W Plankey, and
S R Hoffman, and
C L Boyd, and
K R Dye, and
H F Frierson, and
R L Guerrant, and
R W McCallum
May 1991,
Gut,
B J Marshall, and
M W Plankey, and
S R Hoffman, and
C L Boyd, and
K R Dye, and
H F Frierson, and
R L Guerrant, and
R W McCallum
January 1998,
The Journal of the American Board of Family Practice,
B J Marshall, and
M W Plankey, and
S R Hoffman, and
C L Boyd, and
K R Dye, and
H F Frierson, and
R L Guerrant, and
R W McCallum
March 2015,
Acta gastroenterologica Latinoamericana,
B J Marshall, and
M W Plankey, and
S R Hoffman, and
C L Boyd, and
K R Dye, and
H F Frierson, and
R L Guerrant, and
R W McCallum
February 2002,
Nihon rinsho. Japanese journal of clinical medicine,
B J Marshall, and
M W Plankey, and
S R Hoffman, and
C L Boyd, and
K R Dye, and
H F Frierson, and
R L Guerrant, and
R W McCallum
July 1990,
Digestive diseases and sciences,
