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Five consecutive patients with severe aplastic anemia were treated with antithymocyte globulin followed by cyclosporin A. All received antithymocyte globulin initially, and because of lack of response within a 4 week period, cyclosporin was administered subsequently. Hematologic improvement occurred within four months of initiation of cyclosporin. Four patients no longer require blood product support, while one remains transfusion-dependent. In two patients, thrombocytopenia developed when the cyclosporin was tapered but re-institution of the drug resulted in a prompt improvement of counts. These observations indicate that the sequential use of antithymocyte globulin and cyclosporin may be an effective therapeutic approach in the treatment of severe aplastic anemia.
G C Doolittle, and
D C Bodensteiner, and
B S Skikne, and
M Amare
September 2009,
Indian journal of pediatrics,
G C Doolittle, and
D C Bodensteiner, and
B S Skikne, and
M Amare
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G C Doolittle, and
D C Bodensteiner, and
B S Skikne, and
M Amare
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G C Doolittle, and
D C Bodensteiner, and
B S Skikne, and
M Amare
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G C Doolittle, and
D C Bodensteiner, and
B S Skikne, and
M Amare
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G C Doolittle, and
D C Bodensteiner, and
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M Amare
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G C Doolittle, and
D C Bodensteiner, and
B S Skikne, and
M Amare
February 2019,
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G C Doolittle, and
D C Bodensteiner, and
B S Skikne, and
M Amare
September 1987,
American journal of hematology,
G C Doolittle, and
D C Bodensteiner, and
B S Skikne, and
M Amare
February 1986,
Harefuah,
G C Doolittle, and
D C Bodensteiner, and
B S Skikne, and
M Amare
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American journal of hematology,
