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Chronic myeloid leukemia (CML) is considered to be a pleuripotential stem cell disorder with the capacity to differentiate into myeloid, erythroid, megakaryocytic, and lymphoid cell lines. Consequently, blast crisis (BC) involving each of the above lineages has been well described. Among lymphoblastic crises, differentiation frequently occurs along B-cell lineage. We report four patients of CML who terminated in T-cell extramedullary BC in lymph nodes after a variable duration of chronic phase. The T-lineage was established by characteristic cytochemical staining and reactivity with a panel of anti-T-cell monoclonal antibodies. All four cases were Philadelphia (Ph) chromosome positive and demonstrated the Ph chromosome and associated anomalies (extra Ph, +19) in the lymph nodes. Our data adds to the growing evidence that CML is a disorder of the common stem cell from which T, B, and myeloid precursors originate.
S H Advani, and
H Malhotra, and
P R Kadam, and
R S Iyer, and
G Nanjangud, and
B Balsara, and
T Saikia, and
R Gopal, and
C N Nair
January 2014,
European journal of haematology,
S H Advani, and
H Malhotra, and
P R Kadam, and
R S Iyer, and
G Nanjangud, and
B Balsara, and
T Saikia, and
R Gopal, and
C N Nair
November 1985,
Blood,
S H Advani, and
H Malhotra, and
P R Kadam, and
R S Iyer, and
G Nanjangud, and
B Balsara, and
T Saikia, and
R Gopal, and
C N Nair
January 1991,
Leukemia & lymphoma,
S H Advani, and
H Malhotra, and
P R Kadam, and
R S Iyer, and
G Nanjangud, and
B Balsara, and
T Saikia, and
R Gopal, and
C N Nair
June 1982,
Tumori,
S H Advani, and
H Malhotra, and
P R Kadam, and
R S Iyer, and
G Nanjangud, and
B Balsara, and
T Saikia, and
R Gopal, and
C N Nair
May 1987,
European journal of cancer & clinical oncology,
S H Advani, and
H Malhotra, and
P R Kadam, and
R S Iyer, and
G Nanjangud, and
B Balsara, and
T Saikia, and
R Gopal, and
C N Nair
October 2000,
Leukemia & lymphoma,
S H Advani, and
H Malhotra, and
P R Kadam, and
R S Iyer, and
G Nanjangud, and
B Balsara, and
T Saikia, and
R Gopal, and
C N Nair
March 2015,
Hematology/oncology and stem cell therapy,
S H Advani, and
H Malhotra, and
P R Kadam, and
R S Iyer, and
G Nanjangud, and
B Balsara, and
T Saikia, and
R Gopal, and
C N Nair
December 1995,
Leukemia & lymphoma,
S H Advani, and
H Malhotra, and
P R Kadam, and
R S Iyer, and
G Nanjangud, and
B Balsara, and
T Saikia, and
R Gopal, and
C N Nair
November 1977,
British medical journal,
S H Advani, and
H Malhotra, and
P R Kadam, and
R S Iyer, and
G Nanjangud, and
B Balsara, and
T Saikia, and
R Gopal, and
C N Nair
January 1983,
Folia haematologica (Leipzig, Germany : 1928),
