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We measured neutrophil elastase/alpha 1 proteinase inhibitor complex (E/alpha) levels by ELISA in plasma samples drawn from 19 patients with claudication, before and at 1 and 2 months after initiation of pentoxifylline (PTF), 400 mg. p.o. tid. Plasma E/alpha levels declined in all eight patients whose initial values were more than 300 ng elastase per ml. Whole blood viscosity (wbv) was reduced by two months' treatment in 12 of 14 patients tested. The relative change in wbv was significantly related to the relative change in E/alpha (R2 = 0.8), for patients with elevated initial E/alpha levels, suggesting a common or related mechanism for the two effects. Plasma crosslinked fibrin D-dimer fragments (XDP) measured by ELISA as indicators of coagulation activity were lower compared to pretreatment levels in 9 of 10 samples drawn when symptoms were improved on PTF, whereas they were increased in 6 of 9 samples drawn when symptoms were worse or unchanged. Plasma viscosity, C-reactive protein and alpha 1-acid-glycoprotein did not change significantly with PTF treatment. Together these findings are consistent with the possibility that reduced microvascular neutrophil activation and coagulation play a role in the clinical efficacy of PTF in intermittent claudication.
M S Currie, and
D L Simel, and
R H Christenson, and
C Holmes, and
J Crawford, and
H J Cohen, and
K M Rao
September 1987,
Angiology,
M S Currie, and
D L Simel, and
R H Christenson, and
C Holmes, and
J Crawford, and
H J Cohen, and
K M Rao
November 2009,
Der Anaesthesist,
M S Currie, and
D L Simel, and
R H Christenson, and
C Holmes, and
J Crawford, and
H J Cohen, and
K M Rao
November 1988,
Journal of vascular surgery,
M S Currie, and
D L Simel, and
R H Christenson, and
C Holmes, and
J Crawford, and
H J Cohen, and
K M Rao
July 2004,
Chest,
M S Currie, and
D L Simel, and
R H Christenson, and
C Holmes, and
J Crawford, and
H J Cohen, and
K M Rao
November 1987,
The New Zealand medical journal,
M S Currie, and
D L Simel, and
R H Christenson, and
C Holmes, and
J Crawford, and
H J Cohen, and
K M Rao
August 1987,
The New Zealand medical journal,
M S Currie, and
D L Simel, and
R H Christenson, and
C Holmes, and
J Crawford, and
H J Cohen, and
K M Rao
September 2015,
The Cochrane database of systematic reviews,
M S Currie, and
D L Simel, and
R H Christenson, and
C Holmes, and
J Crawford, and
H J Cohen, and
K M Rao
October 1987,
The New Zealand medical journal,
M S Currie, and
D L Simel, and
R H Christenson, and
C Holmes, and
J Crawford, and
H J Cohen, and
K M Rao
October 2020,
The Cochrane database of systematic reviews,
M S Currie, and
D L Simel, and
R H Christenson, and
C Holmes, and
J Crawford, and
H J Cohen, and
K M Rao
January 1985,
Annals of internal medicine,
