BIOMAT Database Logo BIOMAT Database Logo

Continuous infusion of amphotericin B deoxycholate in the treatment of cryptococcal meningoencephalitis: analysis of safety and fungicidal activity. 2010

Diego Rodrigues Falci, and Luciano Weber Lunardi, and Carina Guedes Ramos, and Mônica Baumgardt Bay, and Valério Rodrigues Aquino, and Luciano Zubaran Goldani
Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Brazil.

We measured fungicidal activity of continuous infusion of amphotericin B deoxycholate plus 5'flucytosine using quantitative cultures of cerebrospinal fluid (CSF) obtained from lumbar punctures of human immunodeficiency virus (HIV)-infected patients with neurocryptococcosis during 14 days of treatment. Glomerular renal function was preserved in all patients. Mycological efficacy with progressive reduction in CSF cryptococcal colony-forming units was comparable to standard 4-h infusion of amphotericin B.

UI MeSH Term Description Entries
D007262 Infusions, Intravenous The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it. Drip Infusions,Intravenous Drip,Intravenous Infusions,Drip Infusion,Drip, Intravenous,Infusion, Drip,Infusion, Intravenous,Infusions, Drip,Intravenous Infusion
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D002555 Cerebrospinal Fluid A watery fluid that is continuously produced in the CHOROID PLEXUS and circulates around the surface of the BRAIN; SPINAL CORD; and in the CEREBRAL VENTRICLES. Cerebro Spinal Fluid,Cerebro Spinal Fluids,Cerebrospinal Fluids,Fluid, Cerebro Spinal,Fluid, Cerebrospinal,Fluids, Cerebro Spinal,Fluids, Cerebrospinal,Spinal Fluid, Cerebro,Spinal Fluids, Cerebro
D003454 Cryptococcus A mitosporic Tremellales fungal genus whose species usually have a capsule and do not form pseudomycellium. Teleomorphs include Filobasidiella and Fidobasidium. Torula
D003840 Deoxycholic Acid A bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent. Deoxycholate,Desoxycholic Acid,Kybella,Choleic Acid,Deoxycholic Acid, 12beta-Isomer,Deoxycholic Acid, 3beta-Isomer,Deoxycholic Acid, 5alpha-Isomer,Deoxycholic Acid, Disodium Salt,Deoxycholic Acid, Magnesium (2:1) Salt,Deoxycholic Acid, Monoammonium Salt,Deoxycholic Acid, Monopotassium Salt,Deoxycholic Acid, Monosodium Salt,Deoxycholic Acid, Sodium Salt, 12beta-Isomer,Dihydroxycholanoic Acid,Lagodeoxycholic Acid,Sodium Deoxycholate,12beta-Isomer Deoxycholic Acid,3beta-Isomer Deoxycholic Acid,5alpha-Isomer Deoxycholic Acid,Deoxycholate, Sodium,Deoxycholic Acid, 12beta Isomer,Deoxycholic Acid, 3beta Isomer,Deoxycholic Acid, 5alpha Isomer
D004338 Drug Combinations Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture. Drug Combination,Combination, Drug,Combinations, Drug
D005260 Female Females
D005437 Flucytosine A fluorinated cytosine analog that is used as an antifungal agent. 5-Fluorocytosine,Alcobon,Ancobon,Ancotil
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

Diego Rodrigues Falci, and Luciano Weber Lunardi, and Carina Guedes Ramos, and Mônica Baumgardt Bay, and Valério Rodrigues Aquino, and Luciano Zubaran Goldani
continuous versus conventional infusion of amphotericin B deoxycholate: a meta-analysis.
January 2013, PloS one,
Diego Rodrigues Falci, and Luciano Weber Lunardi, and Carina Guedes Ramos, and Mônica Baumgardt Bay, and Valério Rodrigues Aquino, and Luciano Zubaran Goldani
Minimizing nephrotoxicity using continuous infusion of deoxycholate amphotericin B.
October 2014, The Pediatric infectious disease journal,
Diego Rodrigues Falci, and Luciano Weber Lunardi, and Carina Guedes Ramos, and Mônica Baumgardt Bay, and Valério Rodrigues Aquino, and Luciano Zubaran Goldani
Continuous infusion of amphotericin B deoxycholate for the treatment of life-threatening Candida infections.
October 2013, American journal of respiratory and critical care medicine,
Diego Rodrigues Falci, and Luciano Weber Lunardi, and Carina Guedes Ramos, and Mônica Baumgardt Bay, and Valério Rodrigues Aquino, and Luciano Zubaran Goldani
Continuous infusion of amphotericin B deoxycholate: an innovative, low-cost strategy in antifungal treatment.
March 2011, Mycoses,
Diego Rodrigues Falci, and Luciano Weber Lunardi, and Carina Guedes Ramos, and Mônica Baumgardt Bay, and Valério Rodrigues Aquino, and Luciano Zubaran Goldani
Reply: continuous infusion of amphotericin B deoxycholate for the treatment of life-threatening Candida infections.
October 2013, American journal of respiratory and critical care medicine,
Diego Rodrigues Falci, and Luciano Weber Lunardi, and Carina Guedes Ramos, and Mônica Baumgardt Bay, and Valério Rodrigues Aquino, and Luciano Zubaran Goldani
[CRYPTOCOCCAL MENINGOENCEPHALITIS UNSUCCESSFULLY TREATED WITH AMPHOTERICIN B].
August 1963, Casopis lekaru ceskych,
Diego Rodrigues Falci, and Luciano Weber Lunardi, and Carina Guedes Ramos, and Mônica Baumgardt Bay, and Valério Rodrigues Aquino, and Luciano Zubaran Goldani
The treatment of cryptococcal meningitis with amphotericin B, a new fungicidal agent.
August 1958, Annals of internal medicine,
Diego Rodrigues Falci, and Luciano Weber Lunardi, and Carina Guedes Ramos, and Mônica Baumgardt Bay, and Valério Rodrigues Aquino, and Luciano Zubaran Goldani
Brief report: practicability and safety of amphotericin B deoxycholate as continuous infusion in neutropenic patients with hematological malignancies.
August 2005, Leukemia & lymphoma,
Diego Rodrigues Falci, and Luciano Weber Lunardi, and Carina Guedes Ramos, and Mônica Baumgardt Bay, and Valério Rodrigues Aquino, and Luciano Zubaran Goldani
Amphotericin B deoxycholate administered by continuous infusion: does the dosage make a difference?
April 2003, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
Diego Rodrigues Falci, and Luciano Weber Lunardi, and Carina Guedes Ramos, and Mônica Baumgardt Bay, and Valério Rodrigues Aquino, and Luciano Zubaran Goldani
Continuous infusion of escalated doses of amphotericin B deoxycholate: an open-label observational study.
April 2003, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
Copied contents to your clipboard!