Carcinoembryonic antigen surge in metastatic colorectal cancer patients responding to irinotecan combination chemotherapy. 2010

Xin An, and Pei-Rong Ding, and Xiao-Juan Xiang, and Zhi-Qiang Wang, and Feng-Hua Wang, and Fen Feng, and Wen-Qi Jiang, and You-Jian He, and Rui-Hua Xu, and Yu-Hong Li
State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, P.R. China.

OBJECTIVE Oxaliplatin (OXA)-induced carcinoembryonic antigen (CEA) surge was reported to be associated with a clinical benefit. The aim of this study was to investigate the phenomenon of CEA surge in irinotecan-based chemotherapy. METHODS We retrospectively reviewed 132 patients with metastatic colorectal cancer treated with irinotecan-based chemotherapy. Incidence of a CEA surge and chemotherapy efficacy were investigated. RESULTS Eleven of 99 eligible patients (11.1%) had CEA surges. None of the 11 patients showed progressive disease (four had a partial response, seven had stable disease). CONCLUSIONS A CEA surge can be induced by irinotecan-based chemotherapy. An early increase in CEA after irinotecan-based chemotherapy does not usually indicate progression of disease and failure of therapy, and should not lead to a change of chemotherapy.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009362 Neoplasm Metastasis The transfer of a neoplasm from one organ or part of the body to another remote from the primary site. Metastase,Metastasis,Metastases, Neoplasm,Metastasis, Neoplasm,Neoplasm Metastases,Metastases
D009944 Organoplatinum Compounds Organic compounds which contain platinum as an integral part of the molecule. Compounds, Organoplatinum
D002166 Camptothecin An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity. Camptothecine
D002272 Carcinoembryonic Antigen A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment. Antigens, CD66e,CD66e Antigen,Antigen, CD66e,Antigen, Carcinoembryonic,CD66e Antigens
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000077146 Irinotecan A semisynthetic camptothecin derivative that inhibits DNA TOPOISOMERASE I to prevent nucleic acid synthesis during S PHASE. It is used as an antineoplastic agent for the treatment of COLORECTAL NEOPLASMS and PANCREATIC NEOPLASMS. 7-Ethyl-10-hydroxycamptothecin,CPT 11,CPT-11,Camptosar,Camptothecin-11,Irinotecan Hydrochloride,Irrinotecan,NK012 Compound,SN 38,SN 38 11,SN-38,SN-38-11,7 Ethyl 10 hydroxycamptothecin,CPT11,Camptothecin 11,SN3811
D000077150 Oxaliplatin An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane, and with an oxalate ligand which is displaced to yield active oxaliplatin derivatives. These derivatives form inter- and intra-strand DNA crosslinks that inhibit DNA replication and transcription. Oxaliplatin is an antineoplastic agent that is often administered with FLUOROURACIL and FOLINIC ACID in the treatment of metastatic COLORECTAL NEOPLASMS. Platinum(2+) ethanedioate (1R,2R)-1,2-cyclohexanediamine (1:1:1),1,2-Diaminocyclohexane Platinum Oxalate,1,2-Diamminocyclohexane(trans-1)oxolatoplatinum(II),ACT 078,ACT-078,Cis-oxalato-(trans-l)-1,2-diaminocyclohexane-platinum(II),Eloxatin,Eloxatine,L-OHP Cpd,Oxalato-(1,2-cyclohexanediamine)platinum II,Oxaliplatin, (SP-4-2-(1R-trans))-isomer,Oxaliplatin, (SP-4-2-(1S-trans))-isomer,Oxaliplatin, (SP-4-3-(cis))-isomer,Oxaliplatine,Platinum(II)-1,2-cyclohexanediamine Oxalate,1,2 Diaminocyclohexane Platinum Oxalate,ACT078

Related Publications

Xin An, and Pei-Rong Ding, and Xiao-Juan Xiang, and Zhi-Qiang Wang, and Feng-Hua Wang, and Fen Feng, and Wen-Qi Jiang, and You-Jian He, and Rui-Hua Xu, and Yu-Hong Li
December 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
Xin An, and Pei-Rong Ding, and Xiao-Juan Xiang, and Zhi-Qiang Wang, and Feng-Hua Wang, and Fen Feng, and Wen-Qi Jiang, and You-Jian He, and Rui-Hua Xu, and Yu-Hong Li
January 2006, Oncology,
Xin An, and Pei-Rong Ding, and Xiao-Juan Xiang, and Zhi-Qiang Wang, and Feng-Hua Wang, and Fen Feng, and Wen-Qi Jiang, and You-Jian He, and Rui-Hua Xu, and Yu-Hong Li
January 2003, Annals of oncology : official journal of the European Society for Medical Oncology,
Xin An, and Pei-Rong Ding, and Xiao-Juan Xiang, and Zhi-Qiang Wang, and Feng-Hua Wang, and Fen Feng, and Wen-Qi Jiang, and You-Jian He, and Rui-Hua Xu, and Yu-Hong Li
April 2001, International journal of colorectal disease,
Xin An, and Pei-Rong Ding, and Xiao-Juan Xiang, and Zhi-Qiang Wang, and Feng-Hua Wang, and Fen Feng, and Wen-Qi Jiang, and You-Jian He, and Rui-Hua Xu, and Yu-Hong Li
January 1998, Clinical and investigative medicine. Medecine clinique et experimentale,
Xin An, and Pei-Rong Ding, and Xiao-Juan Xiang, and Zhi-Qiang Wang, and Feng-Hua Wang, and Fen Feng, and Wen-Qi Jiang, and You-Jian He, and Rui-Hua Xu, and Yu-Hong Li
January 2016, Journal of cancer research and therapeutics,
Xin An, and Pei-Rong Ding, and Xiao-Juan Xiang, and Zhi-Qiang Wang, and Feng-Hua Wang, and Fen Feng, and Wen-Qi Jiang, and You-Jian He, and Rui-Hua Xu, and Yu-Hong Li
April 1991, Tumori,
Xin An, and Pei-Rong Ding, and Xiao-Juan Xiang, and Zhi-Qiang Wang, and Feng-Hua Wang, and Fen Feng, and Wen-Qi Jiang, and You-Jian He, and Rui-Hua Xu, and Yu-Hong Li
January 2013, Yonsei medical journal,
Xin An, and Pei-Rong Ding, and Xiao-Juan Xiang, and Zhi-Qiang Wang, and Feng-Hua Wang, and Fen Feng, and Wen-Qi Jiang, and You-Jian He, and Rui-Hua Xu, and Yu-Hong Li
August 1986, Gut,
Xin An, and Pei-Rong Ding, and Xiao-Juan Xiang, and Zhi-Qiang Wang, and Feng-Hua Wang, and Fen Feng, and Wen-Qi Jiang, and You-Jian He, and Rui-Hua Xu, and Yu-Hong Li
December 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
Copied contents to your clipboard!