Analysis of testosterone pulsatility in women with ovulatory menstrual cycles. 2009

Lucia H C Nóbrega, and George D Azevedo, and Josivan G Lima, and Rui A Ferriani, and Poli Mara Spritzer, and Marcos F S Sá, and Técia M O Maranhão
Programa de Pós-graduação em Ciências da Saúde, Universidade Federal do Rio Grande do Norte, Natal, RN, Brasil. josivanlima@gmail.com

OBJECTIVE To evaluate the pattern of the pulsatile secretion of testosterone in normal menstrual cycle. METHODS Eight healthy women with ovulatory menstrual cycles were enrolled. Blood samples were collected at ten-minute intervals for six hours, starting between 7 and 8 am, after a ten-hour fasting, in three phases: mid-follicular (Day 7), late follicular (Day 12) and mid-luteal phase (Day 21). Samples were assayed for testosterone, LH and the baseline also for SHBG. RESULTS Testosterone pulse frequency, mean amplitude pulse, percentage of increment in pulse amplitude, mean duration of pulses and pulse interval were similar in the three phases. LH pulsatility was statistically different among the three phases (p < 0.001) representing normal ovulatory cycles. CONCLUSIONS These data increase the knowledge about the testosterone secretion profile in the human menstrual cycle and can be used as a contribution to clinical investigation in both hyperandrogenism and androgen insufficiency syndrome.

UI MeSH Term Description Entries
D007986 Luteinizing Hormone A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Luteinizing hormone regulates steroid production by the interstitial cells of the TESTIS and the OVARY. The preovulatory LUTEINIZING HORMONE surge in females induces OVULATION, and subsequent LUTEINIZATION of the follicle. LUTEINIZING HORMONE consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH and FSH), but the beta subunit is unique and confers its biological specificity. ICSH (Interstitial Cell Stimulating Hormone),Interstitial Cell-Stimulating Hormone,LH (Luteinizing Hormone),Lutropin,Luteoziman,Luteozyman,Hormone, Interstitial Cell-Stimulating,Hormone, Luteinizing,Interstitial Cell Stimulating Hormone
D008597 Menstrual Cycle The period from onset of one menstrual bleeding (MENSTRUATION) to the next in an ovulating woman or female primate. The menstrual cycle is regulated by endocrine interactions of the HYPOTHALAMUS; the PITUITARY GLAND; the ovaries; and the genital tract. The menstrual cycle is divided by OVULATION into two phases. Based on the endocrine status of the OVARY, there is a FOLLICULAR PHASE and a LUTEAL PHASE. Based on the response in the ENDOMETRIUM, the menstrual cycle is divided into a proliferative and a secretory phase. Endometrial Cycle,Ovarian Cycle,Cycle, Endometrial,Cycle, Menstrual,Cycle, Ovarian,Cycles, Endometrial,Cycles, Menstrual,Cycles, Ovarian,Endometrial Cycles,Menstrual Cycles,Ovarian Cycles
D010507 Periodicity The tendency of a phenomenon to recur at regular intervals; in biological systems, the recurrence of certain activities (including hormonal, cellular, neural) may be annual, seasonal, monthly, daily, or more frequently (ultradian). Cyclicity,Rhythmicity,Biological Rhythms,Bioperiodicity,Biorhythms,Biological Rhythm,Bioperiodicities,Biorhythm,Cyclicities,Periodicities,Rhythm, Biological,Rhythmicities,Rhythms, Biological
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000704 Analysis of Variance A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable. ANOVA,Analysis, Variance,Variance Analysis,Analyses, Variance,Variance Analyses
D013739 Testosterone A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL. 17-beta-Hydroxy-4-Androsten-3-one,17-beta-Hydroxy-8 alpha-4-Androsten-3-one,8-Isotestosterone,AndroGel,Androderm,Andropatch,Androtop,Histerone,Sterotate,Sustanon,Testim,Testoderm,Testolin,Testopel,Testosterone Sulfate,17 beta Hydroxy 4 Androsten 3 one,17 beta Hydroxy 8 alpha 4 Androsten 3 one,8 Isotestosterone
D055815 Young Adult A person between 19 and 24 years of age. Adult, Young,Adults, Young,Young Adults

Related Publications

Lucia H C Nóbrega, and George D Azevedo, and Josivan G Lima, and Rui A Ferriani, and Poli Mara Spritzer, and Marcos F S Sá, and Técia M O Maranhão
June 1990, Current opinion in obstetrics & gynecology,
Lucia H C Nóbrega, and George D Azevedo, and Josivan G Lima, and Rui A Ferriani, and Poli Mara Spritzer, and Marcos F S Sá, and Técia M O Maranhão
April 1999, Fertility and sterility,
Lucia H C Nóbrega, and George D Azevedo, and Josivan G Lima, and Rui A Ferriani, and Poli Mara Spritzer, and Marcos F S Sá, and Técia M O Maranhão
April 1975, Ceskoslovenska gynekologie,
Lucia H C Nóbrega, and George D Azevedo, and Josivan G Lima, and Rui A Ferriani, and Poli Mara Spritzer, and Marcos F S Sá, and Técia M O Maranhão
September 1988, Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology,
Lucia H C Nóbrega, and George D Azevedo, and Josivan G Lima, and Rui A Ferriani, and Poli Mara Spritzer, and Marcos F S Sá, and Técia M O Maranhão
January 1968, The Journal of obstetrics and gynaecology of the British Commonwealth,
Lucia H C Nóbrega, and George D Azevedo, and Josivan G Lima, and Rui A Ferriani, and Poli Mara Spritzer, and Marcos F S Sá, and Técia M O Maranhão
April 1985, International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics,
Lucia H C Nóbrega, and George D Azevedo, and Josivan G Lima, and Rui A Ferriani, and Poli Mara Spritzer, and Marcos F S Sá, and Técia M O Maranhão
June 2019, Journal of pediatric and adolescent gynecology,
Lucia H C Nóbrega, and George D Azevedo, and Josivan G Lima, and Rui A Ferriani, and Poli Mara Spritzer, and Marcos F S Sá, and Técia M O Maranhão
January 1988, Hormone research,
Lucia H C Nóbrega, and George D Azevedo, and Josivan G Lima, and Rui A Ferriani, and Poli Mara Spritzer, and Marcos F S Sá, and Técia M O Maranhão
December 1973, American journal of obstetrics and gynecology,
Lucia H C Nóbrega, and George D Azevedo, and Josivan G Lima, and Rui A Ferriani, and Poli Mara Spritzer, and Marcos F S Sá, and Técia M O Maranhão
August 1972, American journal of obstetrics and gynecology,
Copied contents to your clipboard!