BIOMAT Database Logo BIOMAT Database Logo

Fanconi's anaemia and pregnancy. 1991

B P Alter, and C L Frissora, and D S Halpérin, and M H Freedman, and U Chitkara, and E Alvarez, and L Lynch, and B Adler-Brecher, and A D Auerbach
Polly Annenberg Levee Hematology Center, Department of Medicine, Mount Sinai School of Medicine, New York, N.Y. 10029.

We have identified six new cases of Fanconi's anaemia (FA) who had pregnancies, and reviewed 11 others from the literature. At least 110 FA females have reached 16 years of age or more, of whom 15% became pregnant. There were a total of 26 pregnancies, resulting in 19 births and 18 surviving children. Anaemia and/or thrombocytopenia worsened during pregnancy in 10 patients, but five subsequently improved: seven had no haematological problems. Seven of the FA patients who had pregnancies died subsequently from cancer, and two from thrombocytopenic bleeding 3 and 20 years later. There were no peripartum deaths. Pregnancy in FA is clearly possible, with increased risks that are manageable from both the haematological and the obstetric aspects.

UI MeSH Term Description Entries
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D011250 Pregnancy Complications, Hematologic The co-occurrence of pregnancy and a blood disease (HEMATOLOGIC DISEASES) which involves BLOOD CELLS or COAGULATION FACTORS. The hematologic disease may precede or follow FERTILIZATION and it may or may not have a deleterious effect on the pregnant woman or FETUS. Complications, Hematologic Pregnancy,Hematologic Pregnancy Complications,Pregnancy Complications, Hematological,Pregnancy, Hematologic Complications,Complication, Hematologic Pregnancy,Complication, Hematological Pregnancy,Complications, Hematological Pregnancy,Hematologic Pregnancy Complication,Hematological Pregnancy Complication,Hematological Pregnancy Complications,Pregnancies, Hematologic Complications,Pregnancy Complication, Hematologic,Pregnancy Complication, Hematological
D011256 Pregnancy Outcome Results of conception and ensuing pregnancy, including LIVE BIRTH; STILLBIRTH; or SPONTANEOUS ABORTION. The outcome may follow natural or artificial insemination or any of the various ASSISTED REPRODUCTIVE TECHNIQUES, such as EMBRYO TRANSFER or FERTILIZATION IN VITRO. Outcome, Pregnancy,Outcomes, Pregnancy,Pregnancy Outcomes
D001772 Blood Cell Count The number of LEUKOCYTES and ERYTHROCYTES per unit volume in a sample of venous BLOOD. A complete blood count (CBC) also includes measurement of the HEMOGLOBIN; HEMATOCRIT; and ERYTHROCYTE INDICES. Blood Cell Number,Blood Count, Complete,Blood Cell Counts,Blood Cell Numbers,Blood Counts, Complete,Complete Blood Count,Complete Blood Counts,Count, Blood Cell,Count, Complete Blood,Counts, Blood Cell,Counts, Complete Blood,Number, Blood Cell,Numbers, Blood Cell
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D005199 Fanconi Anemia Congenital disorder affecting all bone marrow elements, resulting in ANEMIA; LEUKOPENIA; and THROMBOPENIA, and associated with cardiac, renal, and limb malformations as well as dermal pigmentary changes. Spontaneous CHROMOSOME BREAKAGE is a feature of this disease along with predisposition to LEUKEMIA. There are at least 7 complementation groups in Fanconi anemia: FANCA, FANCB, FANCC, FANCD1, FANCD2, FANCE, FANCF, FANCG, and FANCL. (from Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id Anemia, Fanconi,Fanconi Hypoplastic Anemia,Fanconi Pancytopenia,Fanconi Panmyelopathy,Fanconi's Anemia,Anemia, Fanconi's,Anemias, Fanconi,Fanconi Anemias
D005260 Female Females
D005298 Fertility The capacity to conceive or to induce conception. It may refer to either the male or female. Fecundity,Below Replacement Fertility,Differential Fertility,Fecundability,Fertility Determinants,Fertility Incentives,Fertility Preferences,Fertility, Below Replacement,Marital Fertility,Natural Fertility,Subfecundity,World Fertility Survey,Determinant, Fertility,Determinants, Fertility,Fertility Determinant,Fertility Incentive,Fertility Preference,Fertility Survey, World,Fertility Surveys, World,Fertility, Differential,Fertility, Marital,Fertility, Natural,Preference, Fertility,Preferences, Fertility,Survey, World Fertility,Surveys, World Fertility,World Fertility Surveys
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths

Related Publications

B P Alter, and C L Frissora, and D S Halpérin, and M H Freedman, and U Chitkara, and E Alvarez, and L Lynch, and B Adler-Brecher, and A D Auerbach
Fanconi's anaemia in pregnancy. A case report.
December 1990, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
B P Alter, and C L Frissora, and D S Halpérin, and M H Freedman, and U Chitkara, and E Alvarez, and L Lynch, and B Adler-Brecher, and A D Auerbach
Fanconi's anaemia.
July 1974, The Journal of the Association of Physicians of India,
B P Alter, and C L Frissora, and D S Halpérin, and M H Freedman, and U Chitkara, and E Alvarez, and L Lynch, and B Adler-Brecher, and A D Auerbach
Fanconi's anaemia.
August 2003, British journal of haematology,
B P Alter, and C L Frissora, and D S Halpérin, and M H Freedman, and U Chitkara, and E Alvarez, and L Lynch, and B Adler-Brecher, and A D Auerbach
Fanconi's anaemia.
January 1971, Indian pediatrics,
B P Alter, and C L Frissora, and D S Halpérin, and M H Freedman, and U Chitkara, and E Alvarez, and L Lynch, and B Adler-Brecher, and A D Auerbach
Fanconi's anaemia.
April 1973, The Quarterly journal of medicine,
B P Alter, and C L Frissora, and D S Halpérin, and M H Freedman, and U Chitkara, and E Alvarez, and L Lynch, and B Adler-Brecher, and A D Auerbach
Neonatal Aplastic Anaemia and Fanconi's Anaemia.
February 1963, Archives of disease in childhood,
B P Alter, and C L Frissora, and D S Halpérin, and M H Freedman, and U Chitkara, and E Alvarez, and L Lynch, and B Adler-Brecher, and A D Auerbach
[Updating Fanconi's anaemia].
January 2003, Anales del sistema sanitario de Navarra,
B P Alter, and C L Frissora, and D S Halpérin, and M H Freedman, and U Chitkara, and E Alvarez, and L Lynch, and B Adler-Brecher, and A D Auerbach
FANCONI'S APLASTIC ANAEMIA.
March 1964, Irish journal of medical science,
B P Alter, and C L Frissora, and D S Halpérin, and M H Freedman, and U Chitkara, and E Alvarez, and L Lynch, and B Adler-Brecher, and A D Auerbach
Fanconi's anaemia and its variability.
September 1993, British journal of haematology,
B P Alter, and C L Frissora, and D S Halpérin, and M H Freedman, and U Chitkara, and E Alvarez, and L Lynch, and B Adler-Brecher, and A D Auerbach
Fanconi's anaemia and cerebrovascular anomaly.
July 2011, BMJ case reports,
Copied contents to your clipboard!