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Thymidine kinase and deoxycytidine kinase in HIV-infected children. 2009
Francesca Falasca, and
Paola Maida, and
Arianna Boni, and
Stefania Bernardi, and
Laura Cursi, and
Bambina Rizzo, and
Guido Antonelli, and
Guido Castelli Gattinara, and
Ombretta Turriziani
Department of Experimental Medicine, Virology Section, "Sapienza" University of Rome, Italy.
It has been demonstrated that HIV infection may affect the levels of thymidine kinase (TK) and deoxycytidine kinase (dCK) in peripheral blood mononuclear cells from HIV infected adults. The aim of this study was to examine the effect of HIV infection and/or antiretroviral therapy on the activity of the above enzymes in HIV-infected children. The results showed that an inter-individual variability in TK and dCK activities does exist in both HIV infected and uninfected children. TK and dCK levels in PBMC from HIV infected and non infected children did not significantly differ. Furthermore, the therapeutic regimen, including zidovudine, does not seem to affect TK activity.
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