-transparent.png){kind=logo}
1. Leucine-enkephalin and some analogues were assayed for activity in vitro on the mouse vas deferens and for binding to opiate receptors from rat brain. 2. The experimental data were analysed in terms of the stringency for glycine, a D-amino acid or an L-amino acid at each position in the peptide. 3. The observed configurational specificity was compared with the stringency that would be predicted to occur if enkephalin adopted certain hydrogen-bonded conformations at the receptor. 4. A small subset of the conformations examined was found to be compatible with the experimental data.
Related Publications
C R Beddell, and
R B Clark, and
L A Lowe, and
S Wilkinson, and
K J Chang, and
P Cuatrecasas, and
R Miller
August 1988,
Indian journal of biochemistry & biophysics,
C R Beddell, and
R B Clark, and
L A Lowe, and
S Wilkinson, and
K J Chang, and
P Cuatrecasas, and
R Miller
August 2002,
Biopolymers,
C R Beddell, and
R B Clark, and
L A Lowe, and
S Wilkinson, and
K J Chang, and
P Cuatrecasas, and
R Miller
October 1989,
The EMBO journal,
C R Beddell, and
R B Clark, and
L A Lowe, and
S Wilkinson, and
K J Chang, and
P Cuatrecasas, and
R Miller
July 1988,
Rapid communications in mass spectrometry : RCM,
C R Beddell, and
R B Clark, and
L A Lowe, and
S Wilkinson, and
K J Chang, and
P Cuatrecasas, and
R Miller
January 1990,
Biopolymers,
C R Beddell, and
R B Clark, and
L A Lowe, and
S Wilkinson, and
K J Chang, and
P Cuatrecasas, and
R Miller
January 1981,
The Journal of pharmacy and pharmacology,
C R Beddell, and
R B Clark, and
L A Lowe, and
S Wilkinson, and
K J Chang, and
P Cuatrecasas, and
R Miller
November 1986,
Biochemistry,
C R Beddell, and
R B Clark, and
L A Lowe, and
S Wilkinson, and
K J Chang, and
P Cuatrecasas, and
R Miller
January 1979,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
C R Beddell, and
R B Clark, and
L A Lowe, and
S Wilkinson, and
K J Chang, and
P Cuatrecasas, and
R Miller
April 1984,
Journal of pharmaceutical sciences,
C R Beddell, and
R B Clark, and
L A Lowe, and
S Wilkinson, and
K J Chang, and
P Cuatrecasas, and
R Miller
January 2004,
Current topics in medicinal chemistry,
