Influence of the thyroid on exocrine pancreatic function. 1991

L Gullo, and R Pezzilli, and B Bellanova, and A D'Ambrosi, and V Alvisi, and L Barbara
Unit for the Study of Pancreatic Disease, University of Bologna, Italy.

Exocrine pancreatic function was studied in 15 patients with hypothyroidism and 15 healthy subjects by means of the amino acid consumption test, a new tubeless test based on the measurement of plasma amino acid uptake by the pancreas during pancreatic enzyme synthesis stimulation. Nine of the 15 patients were also studied after they had become euthyroid following thyroxine treatment. Pancreatic function was significantly reduced in patients with hypothyroidism compared with healthy subjects. Treatment with thyroxine restored pancreatic function to normal. In two additional hypothyroid patients studied by means of duodenal intubation, pancreatic secretion of both bicarbonate and enzymes was found to be significantly decreased. It was concluded that the thyroid gland plays an essential role in maintaining the functional integrity of the exocrine pancreas in humans.

UI MeSH Term Description Entries
D007037 Hypothyroidism A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA. It may be primary or secondary due to other pituitary disease, or hypothalamic dysfunction. Central Hypothyroidism,Primary Hypothyroidism,Secondary Hypothyroidism,TSH Deficiency,Thyroid-Stimulating Hormone Deficiency,Central Hypothyroidisms,Deficiency, TSH,Deficiency, Thyroid-Stimulating Hormone,Hormone Deficiency, Thyroid-Stimulating,Hypothyroidism, Central,Hypothyroidism, Primary,Hypothyroidism, Secondary,Hypothyroidisms,Primary Hypothyroidisms,Secondary Hypothyroidisms,TSH Deficiencies,Thyroid Stimulating Hormone Deficiency,Thyroid-Stimulating Hormone Deficiencies
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010179 Pancreas A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.
D010186 Pancreatic Function Tests Tests based on the biochemistry and physiology of the exocrine pancreas and involving analysis of blood, duodenal contents, feces, or urine for products of pancreatic secretion. Function Test, Pancreatic,Function Tests, Pancreatic,Pancreatic Function Test,Test, Pancreatic Function,Tests, Pancreatic Function
D002108 Ceruletide A specific decapeptide obtained from the skin of Hila caerulea, an Australian amphibian. Caerulein is similar in action and composition to CHOLECYSTOKININ. It stimulates gastric, biliary, and pancreatic secretion; and certain smooth muscle. It is used in paralytic ileus and as diagnostic aid in pancreatic malfunction. Caerulein,Cerulein,Ceruletid,FI-6934,Takus,FI 6934,FI6934
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly

Related Publications

L Gullo, and R Pezzilli, and B Bellanova, and A D'Ambrosi, and V Alvisi, and L Barbara
January 1972, Surgical forum,
L Gullo, and R Pezzilli, and B Bellanova, and A D'Ambrosi, and V Alvisi, and L Barbara
July 1982, Gastroenterology,
L Gullo, and R Pezzilli, and B Bellanova, and A D'Ambrosi, and V Alvisi, and L Barbara
January 2014, The British journal of surgery,
L Gullo, and R Pezzilli, and B Bellanova, and A D'Ambrosi, and V Alvisi, and L Barbara
January 1983, Digestion,
L Gullo, and R Pezzilli, and B Bellanova, and A D'Ambrosi, and V Alvisi, and L Barbara
January 2013, Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology,
L Gullo, and R Pezzilli, and B Bellanova, and A D'Ambrosi, and V Alvisi, and L Barbara
May 1971, Gastroenterology,
L Gullo, and R Pezzilli, and B Bellanova, and A D'Ambrosi, and V Alvisi, and L Barbara
February 1980, Comprehensive therapy,
L Gullo, and R Pezzilli, and B Bellanova, and A D'Ambrosi, and V Alvisi, and L Barbara
May 1989, International journal of pancreatology : official journal of the International Association of Pancreatology,
L Gullo, and R Pezzilli, and B Bellanova, and A D'Ambrosi, and V Alvisi, and L Barbara
July 1999, Journal of pediatric gastroenterology and nutrition,
L Gullo, and R Pezzilli, and B Bellanova, and A D'Ambrosi, and V Alvisi, and L Barbara
March 1969, Gastroenterology,
Copied contents to your clipboard!