Provocation of aspiration reflexes and their effects on the pattern of cough and reflex apnea in cats. 2009

I Poliacek, and Z Tomori, and M Simera, and H Barani, and N Visnovcova, and E Halasova, and V Donic, and J Jakus
Institute of Medical Biophysics, Comenius University, Martin, Slovakia. poliacek@jfmed.uniba.sk

Aspiration reflexes (AspRs) manifesting as reflex spasmodic inspirations and their effects on motor pattern of tracheobronchial cough and reflex apnea were studied on 22 spontaneously breathing pentobarbitone-anesthetized cats. AspRs induced during cough inspiration enhanced peak inspiratory (P<0.01) and expiratory (P<0.02) esophageal pressures, amplitudes of diaphragm (P<0.01) and abdominal muscles (P<0.05) EMG activity, and prolonged the entire expiratory period (P<0.01) and total cycle duration (P<0.05) of cough. Transient inhibitions and splits of cough expiration frequently occurred with AspR within active cough expiratory period; however, cough spatiotemporal characteristics were not altered significantly. Sub-threshold nasopharyngeal stimulation failing to provoke AspR had no significant effects on coughing. Hering-Breuer inflation apnea was moderately prolonged by AspRs (20%; P<0.05), unlike the apnea produced by continual mechanical laryngeal stimulation. AspRs are inducible during tested behaviors interacting with their motor pattern. Central mechanisms involving pulmonary stretch receptor stimulation is suggested for modulation of cough and inflation apnea by AspR.

UI MeSH Term Description Entries
D010812 Physical Stimulation Act of eliciting a response from a person or organism through physical contact. Stimulation, Physical,Physical Stimulations,Stimulations, Physical
D011661 Pulmonary Stretch Receptors Stretch receptors found in the bronchi and bronchioles. Pulmonary stretch receptors are sensors for a reflex which stops inspiration. In humans, the reflex is protective and is probably not activated during normal respiration. Receptors, Pulmonary Stretch,Receptors, Stretch, Pulmonary,Stretch Receptors, Pulmonary,Lung Stretch Receptors,Receptors, Stretch, Lung,Stretch Receptors, Lung,Lung Stretch Receptor,Pulmonary Stretch Receptor,Receptor, Lung Stretch,Receptor, Pulmonary Stretch,Receptors, Lung Stretch,Stretch Receptor, Lung,Stretch Receptor, Pulmonary
D012018 Reflex An involuntary movement or exercise of function in a part, excited in response to a stimulus applied to the periphery and transmitted to the brain or spinal cord.
D002415 Cats The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801) Felis catus,Felis domesticus,Domestic Cats,Felis domestica,Felis sylvestris catus,Cat,Cat, Domestic,Cats, Domestic,Domestic Cat
D003371 Cough A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs. Coughs
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001049 Apnea A transient absence of spontaneous respiration. Apneas
D001239 Inhalation The act of BREATHING in. Inhaling,Inspiration, Respiratory,Respiratory Inspiration
D053120 Respiratory Aspiration Inhaling liquid or solids, such as stomach contents, or other FOREIGN OBJECTS, into the RESPIRATORY TRACT. When this causes severe lung damage, it is called ASPIRATION PNEUMONIA. Accidental Aspiration,Foreign Body Aspiration,Aspiration, Respiratory,Accidental Aspirations,Aspiration, Accidental,Aspiration, Foreign Body,Aspirations, Accidental,Aspirations, Foreign Body,Body Aspiration, Foreign,Body Aspirations, Foreign,Foreign Body Aspirations

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