BIOMAT Database Logo BIOMAT Database Logo

HLA antigens in Italian multiple sclerosis patients. 1991

L La Mantia, and M T Illeni, and C Milanese, and A Salmaggi, and M Eoli, and G Pellegris, and A Nespolo
Divisione Neurologica e Laboratorio Analisi dell'Istituto Nazionale Neurologico C. Besta, Milano.

We analyzed HLA-A, -C, -B, -DR and -DQ specificities in 104 Italian multiple sclerosis patients and in 905 healthy controls. The frequencies of HLA-A23, A26, Cw4, DR3 and, especially DR5 antigens were significantly higher in multiple sclerosis patients than in controls. Patients with progressive course were characterized by high frequencies of B7, B8 and DR3 antigens: Cw1 and DRw11 shows a negative correlation with the extent of intrathecal IgG production. These data confirm that the HLA system may influence the clinical expression and the immune responses to the disease.

UI MeSH Term Description Entries
D007074 Immunoglobulin G The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B. Gamma Globulin, 7S,IgG,IgG Antibody,Allerglobuline,IgG(T),IgG1,IgG2,IgG2A,IgG2B,IgG3,IgG4,Immunoglobulin GT,Polyglobin,7S Gamma Globulin,Antibody, IgG,GT, Immunoglobulin
D007558 Italy A country in southern Europe, a peninsula extending into the central Mediterranean Sea, northeast of Tunisia. The capital is Rome. Sardinia
D009103 Multiple Sclerosis An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903) MS (Multiple Sclerosis),Multiple Sclerosis, Acute Fulminating,Sclerosis, Disseminated,Disseminated Sclerosis,Sclerosis, Multiple
D012016 Reference Values The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality. Normal Range,Normal Values,Reference Ranges,Normal Ranges,Normal Value,Range, Normal,Range, Reference,Ranges, Normal,Ranges, Reference,Reference Range,Reference Value,Value, Normal,Value, Reference,Values, Normal,Values, Reference
D006680 HLA Antigens Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases. Human Leukocyte Antigen,Human Leukocyte Antigens,Leukocyte Antigens,HL-A Antigens,Antigen, Human Leukocyte,Antigens, HL-A,Antigens, HLA,Antigens, Human Leukocyte,Antigens, Leukocyte,HL A Antigens,Leukocyte Antigen, Human,Leukocyte Antigens, Human
D006683 HLA-DQ Antigens A group of the D-related HLA antigens found to differ from the DR antigens in genetic locus and therefore inheritance. These antigens are polymorphic glycoproteins comprising alpha and beta chains and are found on lymphoid and other cells, often associated with certain diseases. HLA-DC Antigens,HLA-MB Antigens,HLA-DC,HLA-DQ,HLA-DS,HLA-DS Antigens,HLA-LB,HLA-LB Antigens,HLA-MB,Antigens, HLA-DC,Antigens, HLA-DQ,Antigens, HLA-DS,Antigens, HLA-LB,Antigens, HLA-MB,HLA DC Antigens,HLA DQ Antigens,HLA DS Antigens,HLA LB Antigens,HLA MB Antigens
D006684 HLA-DR Antigens A subclass of HLA-D antigens that consist of alpha and beta chains. The inheritance of HLA-DR antigens differs from that of the HLA-DQ ANTIGENS and HLA-DP ANTIGENS. HLA-DR,Antigens, HLA-DR,HLA DR Antigens
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D015234 HLA-A Antigens Polymorphic class I human histocompatibility (HLA) surface antigens present on almost all nucleated cells. At least 20 antigens have been identified which are encoded by the A locus of multiple alleles on chromosome 6. They serve as targets for T-cell cytolytic responses and are involved with acceptance or rejection of tissue/organ grafts. Antigens, HLA-A,HLA-A,Antigens, HLA A,HLA A Antigens
D015235 HLA-B Antigens Class I human histocompatibility (HLA) surface antigens encoded by more than 30 detectable alleles on locus B of the HLA complex, the most polymorphic of all the HLA specificities. Several of these antigens (e.g., HLA-B27, -B7, -B8) are strongly associated with predisposition to rheumatoid and other autoimmune disorders. Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic T lymphocytes. Antigens, HLA-B,HLA-B Antigen,HLA-B,Antigen, HLA-B,Antigens, HLA B,HLA B Antigen,HLA B Antigens

Related Publications

L La Mantia, and M T Illeni, and C Milanese, and A Salmaggi, and M Eoli, and G Pellegris, and A Nespolo
[HLA antigens in multiple sclerosis].
September 1980, Ceskoslovenska neurologie a neurochirurgie,
L La Mantia, and M T Illeni, and C Milanese, and A Salmaggi, and M Eoli, and G Pellegris, and A Nespolo
HLA antigens in multiple sclerosis.
June 1977, Journal of the neurological sciences,
L La Mantia, and M T Illeni, and C Milanese, and A Salmaggi, and M Eoli, and G Pellegris, and A Nespolo
HLA antigens in multiple sclerosis.
June 1976, Neurology,
L La Mantia, and M T Illeni, and C Milanese, and A Salmaggi, and M Eoli, and G Pellegris, and A Nespolo
HLA antigens in multiple sclerosis.
December 1977, Proceedings of the Royal Society of Medicine,
L La Mantia, and M T Illeni, and C Milanese, and A Salmaggi, and M Eoli, and G Pellegris, and A Nespolo
HLA antigens in black American patients with multiple sclerosis.
March 1977, Transplantation proceedings,
L La Mantia, and M T Illeni, and C Milanese, and A Salmaggi, and M Eoli, and G Pellegris, and A Nespolo
HLA antigens in multiple sclerosis in Alsace.
January 1985, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie,
L La Mantia, and M T Illeni, and C Milanese, and A Salmaggi, and M Eoli, and G Pellegris, and A Nespolo
[HLA-DRW antigens and multiple sclerosis].
January 1978, Schweizer Archiv fur Neurologie, Neurochirurgie und Psychiatrie = Archives suisses de neurologie, neurochirurgie et de psychiatrie,
L La Mantia, and M T Illeni, and C Milanese, and A Salmaggi, and M Eoli, and G Pellegris, and A Nespolo
Class II HLA antigens in multiple sclerosis.
May 1989, Journal of neurology, neurosurgery, and psychiatry,
L La Mantia, and M T Illeni, and C Milanese, and A Salmaggi, and M Eoli, and G Pellegris, and A Nespolo
Studies of HLA antigens in multiple sclerosis.
January 1978, Bollettino dell'Istituto sieroterapico milanese,
L La Mantia, and M T Illeni, and C Milanese, and A Salmaggi, and M Eoli, and G Pellegris, and A Nespolo
HLA antigens and multiple sclerosis in Greeks.
July 1984, Journal of neurology, neurosurgery, and psychiatry,
Copied contents to your clipboard!