BRCA2 N372H polymorphism and breast cancer susceptibility: a meta-analysis involving 44,903 subjects. 2010

Li-Xin Qiu, and Lei Yao, and Kai Xue, and Jian Zhang, and Chen Mao, and Bo Chen, and Ping Zhan, and Hui Yuan, and Xi-Chun Hu
Department of Medical Oncology, Cancer Hospital, Fudan University, Shanghai, China.

Published data on the association between BRCA2 N372H polymorphism and breast cancer risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. Crude ORs with 95% CIs were used to assess the strength of association between them. A total of 22 studies including 22,515 cases and 22,388 controls were involved in this meta-analysis. Overall, no significant associations were found between BRCA2 N372H polymorphism and breast cancer risk when all studies pooled into the meta-analysis (NH versus NN: OR = 1.01, 95% CI = 0.97-1.05; HH versus NN: OR = 1.05, 95% CI = 0.97-1.13; dominant model: OR = 1.01, 95% CI = 0.98-1.05; and recessive model: OR = 1.05, 95% CI = 0.98-1.13). In the subgroup analysis by ethnicity, still no significant associations were found for Caucasians, Asians, or Africans. When stratified by study design, statistically significantly elevated risk was found for 372H allele based on population-based studies (HH versus NN: OR = 1.11, 95% CI = 1.01-1.21; dominant model: OR = 1.05, 95% CI = 1.00-1.10; recessive model: OR = 1.09, 95% CI = 1.00-1.18). In conclusion, this meta-analysis suggests that the BRCA2 372H allele may be a low-penetrant risk factor for developing breast cancer. However, large sample and representative population-based studies with homogeneous breast cancer patients and well matched controls are warranted to confirm this finding.

UI MeSH Term Description Entries
D010641 Phenotype The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment. Phenotypes
D011110 Polymorphism, Genetic The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level. Gene Polymorphism,Genetic Polymorphism,Polymorphism (Genetics),Genetic Polymorphisms,Gene Polymorphisms,Polymorphism, Gene,Polymorphisms (Genetics),Polymorphisms, Gene,Polymorphisms, Genetic
D001943 Breast Neoplasms Tumors or cancer of the human BREAST. Breast Cancer,Breast Tumors,Cancer of Breast,Breast Carcinoma,Cancer of the Breast,Human Mammary Carcinoma,Malignant Neoplasm of Breast,Malignant Tumor of Breast,Mammary Cancer,Mammary Carcinoma, Human,Mammary Neoplasm, Human,Mammary Neoplasms, Human,Neoplasms, Breast,Tumors, Breast,Breast Carcinomas,Breast Malignant Neoplasm,Breast Malignant Neoplasms,Breast Malignant Tumor,Breast Malignant Tumors,Breast Neoplasm,Breast Tumor,Cancer, Breast,Cancer, Mammary,Cancers, Mammary,Carcinoma, Breast,Carcinoma, Human Mammary,Carcinomas, Breast,Carcinomas, Human Mammary,Human Mammary Carcinomas,Human Mammary Neoplasm,Human Mammary Neoplasms,Mammary Cancers,Mammary Carcinomas, Human,Neoplasm, Breast,Neoplasm, Human Mammary,Neoplasms, Human Mammary,Tumor, Breast
D005260 Female Females
D005787 Gene Frequency The proportion of one particular in the total of all ALLELES for one genetic locus in a breeding POPULATION. Allele Frequency,Genetic Equilibrium,Equilibrium, Genetic,Allele Frequencies,Frequencies, Allele,Frequencies, Gene,Frequency, Allele,Frequency, Gene,Gene Frequencies
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012307 Risk Factors An aspect of personal behavior or lifestyle, environmental exposure, inborn or inherited characteristic, which, based on epidemiological evidence, is known to be associated with a health-related condition considered important to prevent. Health Correlates,Risk Factor Scores,Risk Scores,Social Risk Factors,Population at Risk,Populations at Risk,Correlates, Health,Factor, Risk,Factor, Social Risk,Factors, Social Risk,Risk Factor,Risk Factor Score,Risk Factor, Social,Risk Factors, Social,Risk Score,Score, Risk,Score, Risk Factor,Social Risk Factor
D016009 Chi-Square Distribution A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another. Chi-Square Test,Chi Square Distribution,Chi Square Test,Chi-Square Distributions,Chi-Square Tests,Distribution, Chi-Square,Distributions, Chi-Square,Test, Chi-Square,Tests, Chi-Square
D016014 Linear Models Statistical models in which the value of a parameter for a given value of a factor is assumed to be equal to a + bx, where a and b are constants. The models predict a linear regression. Linear Regression,Log-Linear Models,Models, Linear,Linear Model,Linear Regressions,Log Linear Models,Log-Linear Model,Model, Linear,Model, Log-Linear,Models, Log-Linear,Regression, Linear,Regressions, Linear
D016017 Odds Ratio The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases. Cross-Product Ratio,Risk Ratio,Relative Odds,Cross Product Ratio,Cross-Product Ratios,Odds Ratios,Odds, Relative,Ratio, Cross-Product,Ratio, Risk,Ratios, Cross-Product,Ratios, Risk,Risk Ratios

Related Publications

Li-Xin Qiu, and Lei Yao, and Kai Xue, and Jian Zhang, and Chen Mao, and Bo Chen, and Ping Zhan, and Hui Yuan, and Xi-Chun Hu
October 2014, Scientific reports,
Li-Xin Qiu, and Lei Yao, and Kai Xue, and Jian Zhang, and Chen Mao, and Bo Chen, and Ping Zhan, and Hui Yuan, and Xi-Chun Hu
June 2010, Breast cancer research and treatment,
Li-Xin Qiu, and Lei Yao, and Kai Xue, and Jian Zhang, and Chen Mao, and Bo Chen, and Ping Zhan, and Hui Yuan, and Xi-Chun Hu
December 2010, Breast cancer research and treatment,
Li-Xin Qiu, and Lei Yao, and Kai Xue, and Jian Zhang, and Chen Mao, and Bo Chen, and Ping Zhan, and Hui Yuan, and Xi-Chun Hu
January 2011, Breast cancer research and treatment,
Li-Xin Qiu, and Lei Yao, and Kai Xue, and Jian Zhang, and Chen Mao, and Bo Chen, and Ping Zhan, and Hui Yuan, and Xi-Chun Hu
October 2016, Oncotarget,
Li-Xin Qiu, and Lei Yao, and Kai Xue, and Jian Zhang, and Chen Mao, and Bo Chen, and Ping Zhan, and Hui Yuan, and Xi-Chun Hu
July 2010, Journal of cancer research and clinical oncology,
Li-Xin Qiu, and Lei Yao, and Kai Xue, and Jian Zhang, and Chen Mao, and Bo Chen, and Ping Zhan, and Hui Yuan, and Xi-Chun Hu
January 2014, PloS one,
Li-Xin Qiu, and Lei Yao, and Kai Xue, and Jian Zhang, and Chen Mao, and Bo Chen, and Ping Zhan, and Hui Yuan, and Xi-Chun Hu
August 2017, Oncotarget,
Li-Xin Qiu, and Lei Yao, and Kai Xue, and Jian Zhang, and Chen Mao, and Bo Chen, and Ping Zhan, and Hui Yuan, and Xi-Chun Hu
January 2014, Asian Pacific journal of cancer prevention : APJCP,
Li-Xin Qiu, and Lei Yao, and Kai Xue, and Jian Zhang, and Chen Mao, and Bo Chen, and Ping Zhan, and Hui Yuan, and Xi-Chun Hu
May 2005, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology,
Copied contents to your clipboard!