Formaldehyde-releasers in cosmetics: relationship to formaldehyde contact allergy. Part 2. Patch test relationship to formaldehyde contact allergy, experimental provocation tests, amount of formaldehyde released, and assessment of risk to consumers allergic to formaldehyde. 2010

Anton de Groot, and Ian R White, and Mari-Ann Flyvholm, and Gerda Lensen, and Pieter-Jan Coenraads
Department of Dermatology, University Medical Center Groningen, University of Groningen, The Netherlands. antondegroot@planet.nl

This is the second part of an article on formaldehyde-releasers in cosmetics. The patch test relationship between the releasers in cosmetics to formaldehyde contact allergy is reviewed and it is assessed whether products preserved with formaldehyde-releasers may contain enough free formaldehyde to pose a threat to individuals with contact allergy to formaldehyde. There is a clear relationship between positive patch test reactions to formaldehyde-releasers and formaldehyde contact allergy: 15% of all reactions to 2-bromo-2-nitropropane-1,3-diol and 40-60% of the reactions to the other releasers are caused by a reaction to the formaldehyde in the test material. There is only fragmented data on the amount of free formaldehyde in cosmetics preserved with formaldehyde donors. However, all releasers (with the exception of 2-bromo-2-nitropropane-1,3-diol, for which adequate data are lacking) can, in the right circumstances of concentration and product composition, release >200 p.p.m. formaldehyde, which may result in allergic contact dermatitis. Whether this is actually the case in any particular product cannot be determined from the ingredient labelling. Therefore, we recommend advising patients allergic to formaldehyde to avoid leave-on cosmetics preserved with quaternium-15, diazolidinyl urea, DMDM hydantoin, or imidazolidinyl urea, acknowledging that many would tolerate some products.

UI MeSH Term Description Entries
D008709 Methenamine An anti-infective agent most commonly used in the treatment of urinary tract infections. Its anti-infective action derives from the slow release of formaldehyde by hydrolysis at acidic pH. (From Martindale, The Extra Pharmacopoeia, 30th ed, p173) Hexamethylenetetramine,Hexamine,Aminoform,Hexamine Silver,Methenamine Silver,Silver Methenamine,Urotropin,Methenamine, Silver,Silver, Hexamine,Silver, Methenamine
D008738 Methyl Ethers A group of compounds that contain the general formula R-OCH3. Ethers, Methyl
D009595 Nitroparaffins Alkanes having one or more nitro (NO2) groups attached to carbon atoms.
D010328 Patch Tests Skin tests in which the sensitizer is applied to a patch of cotton cloth or gauze held in place for approximately 48-72 hours. It is used for the elicitation of a contact hypersensitivity reaction. Patch Testing,Patch Test,Patch Testings,Test, Patch,Testing, Patch,Testings, Patch,Tests, Patch
D011407 Propane A three carbon alkane with the formula H3CCH2CH3.
D003358 Cosmetics Substances intended to be applied to the human body for cleansing, beautifying, promoting attractiveness, or altering the appearance without affecting the body's structure or functions. Included in this definition are skin creams, lotions, perfumes, lipsticks, fingernail polishes, eye and facial makeup preparations, permanent waves, hair colors, toothpastes, and deodorants, as well as any material intended for use as a component of a cosmetic product. (U.S. Food & Drug Administration Center for Food Safety & Applied Nutrition Office of Cosmetics Fact Sheet (web page) Feb 1995) Personal Care Products,Care Product, Personal,Care Products, Personal,Personal Care Product,Product, Personal Care,Products, Personal Care
D004146 Dioxanes Compounds that contain the structure 1,4-dioxane.
D005060 Europe The continent north of AFRICA, west of ASIA and east of the ATLANTIC OCEAN. Northern Europe,Southern Europe,Western Europe
D005557 Formaldehyde A highly reactive aldehyde gas formed by oxidation or incomplete combustion of hydrocarbons. In solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant, and as a laboratory fixative or preservative. Formaldehyde solution (formalin) is considered a hazardous compound, and its vapor toxic. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p717) Formalin,Formol,Methanal,Oxomethane
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

Anton de Groot, and Ian R White, and Mari-Ann Flyvholm, and Gerda Lensen, and Pieter-Jan Coenraads
July 2010, Contact dermatitis,
Anton de Groot, and Ian R White, and Mari-Ann Flyvholm, and Gerda Lensen, and Pieter-Jan Coenraads
August 2009, Contact dermatitis,
Anton de Groot, and Ian R White, and Mari-Ann Flyvholm, and Gerda Lensen, and Pieter-Jan Coenraads
September 2010, Contact dermatitis,
Anton de Groot, and Ian R White, and Mari-Ann Flyvholm, and Gerda Lensen, and Pieter-Jan Coenraads
March 2008, Contact dermatitis,
Anton de Groot, and Ian R White, and Mari-Ann Flyvholm, and Gerda Lensen, and Pieter-Jan Coenraads
May 2010, Contact dermatitis,
Anton de Groot, and Ian R White, and Mari-Ann Flyvholm, and Gerda Lensen, and Pieter-Jan Coenraads
September 2010, Contact dermatitis,
Anton de Groot, and Ian R White, and Mari-Ann Flyvholm, and Gerda Lensen, and Pieter-Jan Coenraads
November 2008, Contact dermatitis,
Anton de Groot, and Ian R White, and Mari-Ann Flyvholm, and Gerda Lensen, and Pieter-Jan Coenraads
July 2022, Contact dermatitis,
Anton de Groot, and Ian R White, and Mari-Ann Flyvholm, and Gerda Lensen, and Pieter-Jan Coenraads
March 2016, Contact dermatitis,
Anton de Groot, and Ian R White, and Mari-Ann Flyvholm, and Gerda Lensen, and Pieter-Jan Coenraads
November 2018, Contact dermatitis,
Copied contents to your clipboard!