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OBJECTIVE To explore the remodeling mechanism of myocardium and sympathetic nerve in pressure overload left ventricular hypertrophy and elucidate the protective effect of statins. METHODS Pressure-overload left ventricular hypertrophy (LVH) of rats was induced by partial coarctation of abdominal aorta; a sham-operated group served as the control (SHAM, n = 22). At 8 weeks post-operation, the animals were divided into two groups and a 12-week treatment period was investigated. At the end of treatment period, echocardiographic evaluations and hemodynamic measurements were performed. Sympathetic innervation was investigated by analyzing nerve growth factor (NGF), growth associated protein-43 (GAP43) and tyrosine hydroxylase (TH). RESULTS In LVH rats, a significant increase of left ventricular weight, left ventricular weight/body weight, echocardiographic left ventricular end-diastolic diameter, interventricular septum thickness, posterior left ventricular wall thickness, left ventricular systolic pressure and dP/dt was observed. The expressions of NGF and GAP43 protein were significantly down-regulated (0.82 +/- 0.06 vs 1.53 +/- 0.10, 0.68 +/- 0.06 vs 0.81 +/- 0.10) and TH level was up-regulated (0.44 +/- 0.10 vs 0.62 +/- 0.06) by RSV treatment. CONCLUSIONS A HMG CoA inhibitor reverses the development of left ventricular hypertrophy and inhibits sympathetic innervation in abdominal aortic-clamped animals.
Ying Liao, and
Xiu-fen Qu, and
Li Liu, and
Xing-mo Dong, and
De-chun Yin
November 1996,
Clinical and experimental hypertension (New York, N.Y. : 1993),
Ying Liao, and
Xiu-fen Qu, and
Li Liu, and
Xing-mo Dong, and
De-chun Yin
March 2001,
Journal of the American College of Cardiology,
Ying Liao, and
Xiu-fen Qu, and
Li Liu, and
Xing-mo Dong, and
De-chun Yin
October 1992,
The American journal of physiology,
Ying Liao, and
Xiu-fen Qu, and
Li Liu, and
Xing-mo Dong, and
De-chun Yin
January 1996,
Journal of molecular and cellular cardiology,
Ying Liao, and
Xiu-fen Qu, and
Li Liu, and
Xing-mo Dong, and
De-chun Yin
October 2000,
Journal of cardiovascular pharmacology,
Ying Liao, and
Xiu-fen Qu, and
Li Liu, and
Xing-mo Dong, and
De-chun Yin
March 1980,
Cardiovascular research,
Ying Liao, and
Xiu-fen Qu, and
Li Liu, and
Xing-mo Dong, and
De-chun Yin
June 2005,
American journal of physiology. Heart and circulatory physiology,
Ying Liao, and
Xiu-fen Qu, and
Li Liu, and
Xing-mo Dong, and
De-chun Yin
February 2007,
Journal of feline medicine and surgery,
Ying Liao, and
Xiu-fen Qu, and
Li Liu, and
Xing-mo Dong, and
De-chun Yin
February 2018,
Scientific reports,
Ying Liao, and
Xiu-fen Qu, and
Li Liu, and
Xing-mo Dong, and
De-chun Yin
May 2005,
Hypertension (Dallas, Tex. : 1979),
