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Homogentisic acid interference in routine urine creatinine determination. 2010
Perry R Loken, and
Mark J Magera, and
Wendy Introne, and
Silvia Tortorelli, and
Dimitar Gavrilov, and
Devin Oglesbee, and
Piero Rinaldo, and
Dietrich Matern, and
Kimiyo Raymond
Biochemical Genetics Laboratory, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
We report the artifactual elevation of homogentisic acid (HGA) in urine from alkaptonuric patients after replacing the creatinine method (Jaffe reaction) in our laboratory with an automated enzymatic method. Samples with elevated HGA by GC-MS had lower creatinine values as determined by the enzymatic method than by the Jaffe reaction. The low creatinine values were due to interference by HGA in the enzymatic method. The enzymatic method is unsuitable for creatinine determination in urine of patients with alkaptonuria.
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