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Lipoproteins in the serum of normal and of cholestatic rats have been studied by crossed immunoelectrophoresis coupled with separations by rate and isopycnic density gradient centrifugation and by gel exclusion chromatography. Normal rat serum contained distinct lipoprotein species closely analogous to human VLDL, LDL, HDL2 and HDL3. Three days after ligation of the common bile duct, there were major changes in the lipoproteins of rat serum. The amounts of VLDL, LDL and of a minor HDL component were elevated and several novel types of lipoprotein were detected. Three of these could be identified as the characteristic lipoprotein of cholestasis, LP-X, as an enlarged and modified HDL and as a lipoprotein of density 1.055 g/ml intermediate in size between LDL and VLDL. Some unusually small VLDL particles were also detected. It is concluded that the changes in rat serum lipoproteins following ligation of the common bile duct are very similar to the changes observed in cholestatic disease in human patients.
R H Hinton, and
B M Mullock
August 1962,
Biochimica et biophysica acta,
R H Hinton, and
B M Mullock
January 1980,
Advances in myocardiology,
R H Hinton, and
B M Mullock
February 2001,
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova,
R H Hinton, and
B M Mullock
August 1997,
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie,
R H Hinton, and
B M Mullock
February 1975,
Experimental and molecular pathology,
R H Hinton, and
B M Mullock
December 1980,
Steroids,
R H Hinton, and
B M Mullock
January 1988,
Pathologica,
R H Hinton, and
B M Mullock
January 1995,
In vivo (Athens, Greece),
R H Hinton, and
B M Mullock
October 2000,
Kidney international,
R H Hinton, and
B M Mullock
April 1978,
British journal of experimental pathology,
