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FcepsilonRIalpha gene (FCER1A) promoter polymorphisms and total serum IgE levels in Japanese atopic dermatitis patients. 2010
Y Niwa, and
D P Potaczek, and
S Kanada, and
A Takagi, and
N Shimokawa, and
T Ito, and
K Mitsuishi, and
Y Okubo, and
M Tajima, and
A Hobo, and
W Ng, and
R Tsuboi, and
S Ikeda, and
H Ogawa, and
K Okumura, and
C Nishiyama
Atopy (Allergy) Research Center, Department of Dermatology, Juntendo University School of Medicine, Tokyo, Japan.
Two promoter polymorphisms of the high-affinity IgE receptor alpha-subunit (FcepsilonRIalpha) gene (FCER1A), -66T>C (rs2251746) and -315C>T (rs2427827), were analysed in Japanese atopic dermatitis subjects. Patients with the -315CT/TT genotype tended to have higher total serum IgE levels, while the proportion of -315CT/TT genotype or the -315T allele was significantly higher in those with highly elevated total serum IgE concentrations.
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