BIOMAT Database Logo BIOMAT Database Logo

Bicyclic compounds repress membrane vesicle production and Pseudomonas quinolone signal synthesis in Pseudomonas aeruginosa. 2010

Yosuke Tashiro, and Masanori Toyofuku, and Toshiaki Nakajima-Kambe, and Hiroo Uchiyama, and Nobuhiko Nomura
Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.

Pseudomonas aeruginosa secretes membrane vesicles (MVs) that deliver several virulence factors as a cargo. We found that indole and its derivative compounds, including 4-hydroxyindole, 5-hydroxyindole, 6-hydroxyindole and isatin, repress MV production significantly. These compounds also repressed the synthesis of Pseudomonas quinolone signal (PQS), which is one of the quorum-sensing signals that upregulate virulence gene expression and positively control MV production. Moreover, we showed that other bicyclic compounds, including 1-naphthol, 2-naphthol, 2,3-dihydroxynaphthalene, 1-aminonaphthalene and 8-quinolinol, significantly repress MV production and PQS synthesis. In conclusion, we provide new information about the chemical structures that inhibit P. aeruginosa virulence.

UI MeSH Term Description Entries
D011550 Pseudomonas aeruginosa A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection. Bacillus aeruginosus,Bacillus pyocyaneus,Bacterium aeruginosum,Bacterium pyocyaneum,Micrococcus pyocyaneus,Pseudomonas polycolor,Pseudomonas pyocyanea
D002462 Cell Membrane The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells. Plasma Membrane,Cytoplasmic Membrane,Cell Membranes,Cytoplasmic Membranes,Membrane, Cell,Membrane, Cytoplasmic,Membrane, Plasma,Membranes, Cell,Membranes, Cytoplasmic,Membranes, Plasma,Plasma Membranes
D000900 Anti-Bacterial Agents Substances that inhibit the growth or reproduction of BACTERIA. Anti-Bacterial Agent,Anti-Bacterial Compound,Anti-Mycobacterial Agent,Antibacterial Agent,Antibiotics,Antimycobacterial Agent,Bacteriocidal Agent,Bacteriocide,Anti-Bacterial Compounds,Anti-Mycobacterial Agents,Antibacterial Agents,Antibiotic,Antimycobacterial Agents,Bacteriocidal Agents,Bacteriocides,Agent, Anti-Bacterial,Agent, Anti-Mycobacterial,Agent, Antibacterial,Agent, Antimycobacterial,Agent, Bacteriocidal,Agents, Anti-Bacterial,Agents, Anti-Mycobacterial,Agents, Antibacterial,Agents, Antimycobacterial,Agents, Bacteriocidal,Anti Bacterial Agent,Anti Bacterial Agents,Anti Bacterial Compound,Anti Bacterial Compounds,Anti Mycobacterial Agent,Anti Mycobacterial Agents,Compound, Anti-Bacterial,Compounds, Anti-Bacterial
D001643 Bridged Bicyclo Compounds Saturated alicyclic hydrocarbon molecules consisting of two rings that have two non-adjacent atoms in common. Bicyclo Compounds,Bicyclo Compounds, Bridged
D015363 Quinolones A group of derivatives of naphthyridine carboxylic acid, quinoline carboxylic acid, or NALIDIXIC ACID. Ketoquinoline,Ketoquinolines,Oxoquinoline,Oxoquinolines,Quinolinone,Quinolinones,Quinolone
D022142 Secretory Vesicles Vesicles derived from the GOLGI APPARATUS containing material to be released at the cell surface. SLMVs,Secretory Granules,Synaptic Like Microvesicles,Synaptic-Like Microvesicles,Zymogen Granules,Condensing Vacuoles,Condensing Vacuole,Granule, Secretory,Granule, Zymogen,Microvesicle, Synaptic-Like,Secretory Granule,Secretory Vesicle,Synaptic Like Microvesicle,Synaptic-Like Microvesicle,Vacuole, Condensing,Vesicle, Secretory,Zymogen Granule

Related Publications

Yosuke Tashiro, and Masanori Toyofuku, and Toshiaki Nakajima-Kambe, and Hiroo Uchiyama, and Nobuhiko Nomura
Membrane Distribution of the Pseudomonas Quinolone Signal Modulates Outer Membrane Vesicle Production in Pseudomonas aeruginosa.
August 2017, mBio,
Yosuke Tashiro, and Masanori Toyofuku, and Toshiaki Nakajima-Kambe, and Hiroo Uchiyama, and Nobuhiko Nomura
Regulation of Pseudomonas quinolone signal synthesis in Pseudomonas aeruginosa.
July 2005, Journal of bacteriology,
Yosuke Tashiro, and Masanori Toyofuku, and Toshiaki Nakajima-Kambe, and Hiroo Uchiyama, and Nobuhiko Nomura
Structural requirements of the Pseudomonas quinolone signal for membrane vesicle stimulation.
May 2009, Journal of bacteriology,
Yosuke Tashiro, and Masanori Toyofuku, and Toshiaki Nakajima-Kambe, and Hiroo Uchiyama, and Nobuhiko Nomura
Pseudomonas Quinolone Signal-Induced Outer Membrane Vesicles Enhance Biofilm Dispersion in Pseudomonas aeruginosa.
November 2020, mSphere,
Yosuke Tashiro, and Masanori Toyofuku, and Toshiaki Nakajima-Kambe, and Hiroo Uchiyama, and Nobuhiko Nomura
Pseudomonas quinolone signal affects membrane vesicle production in not only gram-negative but also gram-positive bacteria.
January 2010, Microbes and environments,
Yosuke Tashiro, and Masanori Toyofuku, and Toshiaki Nakajima-Kambe, and Hiroo Uchiyama, and Nobuhiko Nomura
Stress-induced outer membrane vesicle production by Pseudomonas aeruginosa.
July 2013, Journal of bacteriology,
Yosuke Tashiro, and Masanori Toyofuku, and Toshiaki Nakajima-Kambe, and Hiroo Uchiyama, and Nobuhiko Nomura
CysB Negatively Affects the Transcription of pqsR and Pseudomonas Quinolone Signal Production in Pseudomonas aeruginosa.
June 2015, Journal of bacteriology,
Yosuke Tashiro, and Masanori Toyofuku, and Toshiaki Nakajima-Kambe, and Hiroo Uchiyama, and Nobuhiko Nomura
Interference with Pseudomonas quinolone signal synthesis inhibits virulence factor expression by Pseudomonas aeruginosa.
September 2001, Proceedings of the National Academy of Sciences of the United States of America,
Yosuke Tashiro, and Masanori Toyofuku, and Toshiaki Nakajima-Kambe, and Hiroo Uchiyama, and Nobuhiko Nomura
Candida albicans-produced farnesol stimulates Pseudomonas quinolone signal production in LasR-defective Pseudomonas aeruginosa strains.
October 2010, Microbiology (Reading, England),
Yosuke Tashiro, and Masanori Toyofuku, and Toshiaki Nakajima-Kambe, and Hiroo Uchiyama, and Nobuhiko Nomura
An orphan sensor kinase controls quinolone signal production via MexT in Pseudomonas aeruginosa.
February 2012, Molecular microbiology,
Copied contents to your clipboard!