BIOMAT Database Logo BIOMAT Database Logo

Circulating nucleic acids in cancer and pregnancy. 2010

Pamela Pinzani, and Francesca Salvianti, and Mario Pazzagli, and Claudio Orlando
Department of Clinical Physiopathology, University of Florence and Istituto Toscano Tumori, Viale Pieraccini 6, 50139 Florence, Italy. ppinzani@gmail.com

Circulating nucleic acids are present in the blood of humans and other vertebrates. During the last 10 years researchers actively studied cell-free nucleic acids present in plasma or serum with great expectations of their use as potential biomarkers for cancer and other pathologic conditions. In the present manuscript the main findings related to the principal characteristics of circulating nucleic acids, the hypothesis on their origin and some methodological considerations on sample collection and extraction as well as on some innovative assay methods have been summarized. Recent reports on the importance of circulating nucleic acids in the intercellular exchange of genetic information between eukaryotic cells have been reviewed.

UI MeSH Term Description Entries
D009369 Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. Benign Neoplasm,Cancer,Malignant Neoplasm,Tumor,Tumors,Benign Neoplasms,Malignancy,Malignant Neoplasms,Neoplasia,Neoplasm,Neoplasms, Benign,Cancers,Malignancies,Neoplasias,Neoplasm, Benign,Neoplasm, Malignant,Neoplasms, Malignant
D009696 Nucleic Acids High molecular weight polymers containing a mixture of purine and pyrimidine nucleotides chained together by ribose or deoxyribose linkages. Nucleic Acid,Acid, Nucleic,Acids, Nucleic
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D004247 DNA A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine). DNA, Double-Stranded,Deoxyribonucleic Acid,ds-DNA,DNA, Double Stranded,Double-Stranded DNA,ds DNA
D004273 DNA, Neoplasm DNA present in neoplastic tissue. Neoplasm DNA
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012313 RNA A polynucleotide consisting essentially of chains with a repeating backbone of phosphate and ribose units to which nitrogenous bases are attached. RNA is unique among biological macromolecules in that it can encode genetic information, serve as an abundant structural component of cells, and also possesses catalytic activity. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed) RNA, Non-Polyadenylated,Ribonucleic Acid,Gene Products, RNA,Non-Polyadenylated RNA,Acid, Ribonucleic,Non Polyadenylated RNA,RNA Gene Products,RNA, Non Polyadenylated
D012334 RNA, Neoplasm RNA present in neoplastic tissue. Neoplasm RNA
D015415 Biomarkers Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, ENVIRONMENTAL EXPOSURE and its effects, disease diagnosis; METABOLIC PROCESSES; SUBSTANCE ABUSE; PREGNANCY; cell line development; EPIDEMIOLOGIC STUDIES; etc. Biochemical Markers,Biological Markers,Biomarker,Clinical Markers,Immunologic Markers,Laboratory Markers,Markers, Biochemical,Markers, Biological,Markers, Clinical,Markers, Immunologic,Markers, Laboratory,Markers, Serum,Markers, Surrogate,Markers, Viral,Serum Markers,Surrogate Markers,Viral Markers,Biochemical Marker,Biologic Marker,Biologic Markers,Clinical Marker,Immune Marker,Immune Markers,Immunologic Marker,Laboratory Marker,Marker, Biochemical,Marker, Biological,Marker, Clinical,Marker, Immunologic,Marker, Laboratory,Marker, Serum,Marker, Surrogate,Serum Marker,Surrogate End Point,Surrogate End Points,Surrogate Endpoint,Surrogate Endpoints,Surrogate Marker,Viral Marker,Biological Marker,End Point, Surrogate,End Points, Surrogate,Endpoint, Surrogate,Endpoints, Surrogate,Marker, Biologic,Marker, Immune,Marker, Viral,Markers, Biologic,Markers, Immune

Related Publications

Pamela Pinzani, and Francesca Salvianti, and Mario Pazzagli, and Claudio Orlando
Circulating nucleic acids (CNAs) and cancer--a survey.
January 2007, Biochimica et biophysica acta,
Pamela Pinzani, and Francesca Salvianti, and Mario Pazzagli, and Claudio Orlando
Early pregnancy diagnosis in dairy cows using circulating nucleic acids.
January 2013, Theriogenology,
Pamela Pinzani, and Francesca Salvianti, and Mario Pazzagli, and Claudio Orlando
Circulating Tumor Nucleic Acids: Perspective in Breast Cancer.
January 2010, Breast care (Basel, Switzerland),
Pamela Pinzani, and Francesca Salvianti, and Mario Pazzagli, and Claudio Orlando
Circulating nucleic acids as biomarkers in breast cancer.
January 2013, Breast cancer research : BCR,
Pamela Pinzani, and Francesca Salvianti, and Mario Pazzagli, and Claudio Orlando
Circulating nucleic acids and apoptosis.
September 2001, Annals of the New York Academy of Sciences,
Pamela Pinzani, and Francesca Salvianti, and Mario Pazzagli, and Claudio Orlando
Circulating nucleic acids and evolution.
June 2012, Expert opinion on biological therapy,
Pamela Pinzani, and Francesca Salvianti, and Mario Pazzagli, and Claudio Orlando
[Circulating nucleic acids and infertility].
September 2015, Gynecologie, obstetrique & fertilite,
Pamela Pinzani, and Francesca Salvianti, and Mario Pazzagli, and Claudio Orlando
Circulating Nucleic Acids in Colorectal Cancer: Diagnostic and Prognostic Value.
January 2024, Disease markers,
Pamela Pinzani, and Francesca Salvianti, and Mario Pazzagli, and Claudio Orlando
Circulating nucleic acids as biomarkers of prostate cancer.
December 2013, Biomarkers in medicine,
Pamela Pinzani, and Francesca Salvianti, and Mario Pazzagli, and Claudio Orlando
Circulating nucleic acids and diabetic complications.
September 2006, Annals of the New York Academy of Sciences,
Copied contents to your clipboard!