BIOMAT Database Logo BIOMAT Database Logo

A case of esophageal cancer with multiple lymph node metastases which responded to neoadjuvant chemotherapy (DCF therapy). 2010

Takeshi Shimakawa, and Yoshihiko Naritaka, and Shinichi Asaka, and Noriyuki Isohata, and Kentaro Yamaguchi, and Minoru Murayama, and Soichi Konno, and Takao Katsube, and Kenji Ogawa, and Hiroko Ide
Department of Surgery, Tokyo Women's Medical University Medical Center East, 2-1-10 Nishiogu Arakawa-ku, Tokyo 116-8567, Japan. simakasu@dnh.twmu.ac.jp

It is difficult to perform radical surgery for esophageal cancer with multiple lymph node metastases. Therefore, effective neoadjuvant adjuvant treatment is necessary to achieve successful radical resection. The use of neoadjuvant chemotherapy of docetaxel, cisplatin (CDOP) and 5-fluorouracil (5-FU) (DCF) in an advanced case is reported. The patient (a 67-year-old female) was diagnosed with esophageal cancer, T3, N4, M0, stage IVa with a large number of lymph node metastases in the mediastinum and in the abdominal cavity. Neoadjuvant DCF chemotherapy was initiated in August 2006. Adverse events were mild. A complete response of the lymph node metastases in the abdominal cavity and a partial response of the esophageal lesion were achieved. The surgical procedure included a right thoracolaparotomy followed by a subtotal excision of the esophagus and two-field lymph node dissection. The cancer was diagnosed to be moderately differentiated squamous cell cancer, pT2, pN4(3c) and pstage IVa. The histological efficacy of the chemotherapy was determined to be grade 1a. Two additional courses of DCF therapy were administered followed by postoperative adjuvant chemotherapy.

UI MeSH Term Description Entries
D008207 Lymphatic Metastasis Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system. Lymph Node Metastasis,Lymph Node Metastases,Lymphatic Metastases,Metastasis, Lymph Node
D009367 Neoplasm Staging Methods which attempt to express in replicable terms the extent of the neoplasm in the patient. Cancer Staging,Staging, Neoplasm,Tumor Staging,TNM Classification,TNM Staging,TNM Staging System,Classification, TNM,Classifications, TNM,Staging System, TNM,Staging Systems, TNM,Staging, Cancer,Staging, TNM,Staging, Tumor,System, TNM Staging,Systems, TNM Staging,TNM Classifications,TNM Staging Systems
D002294 Carcinoma, Squamous Cell A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed) Carcinoma, Epidermoid,Carcinoma, Planocellular,Carcinoma, Squamous,Squamous Cell Carcinoma,Carcinomas, Epidermoid,Carcinomas, Planocellular,Carcinomas, Squamous,Carcinomas, Squamous Cell,Epidermoid Carcinoma,Epidermoid Carcinomas,Planocellular Carcinoma,Planocellular Carcinomas,Squamous Carcinoma,Squamous Carcinomas,Squamous Cell Carcinomas
D002945 Cisplatin An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle. Platinum Diamminodichloride,cis-Diamminedichloroplatinum(II),cis-Dichlorodiammineplatinum(II),Biocisplatinum,Dichlorodiammineplatinum,NSC-119875,Platidiam,Platino,Platinol,cis-Diamminedichloroplatinum,cis-Platinum,Diamminodichloride, Platinum,cis Diamminedichloroplatinum,cis Platinum
D004938 Esophageal Neoplasms Tumors or cancer of the ESOPHAGUS. Cancer of Esophagus,Esophageal Cancer,Cancer of the Esophagus,Esophagus Cancer,Esophagus Neoplasm,Neoplasms, Esophageal,Cancer, Esophageal,Cancer, Esophagus,Cancers, Esophageal,Cancers, Esophagus,Esophageal Cancers,Esophageal Neoplasm,Esophagus Cancers,Esophagus Neoplasms,Neoplasm, Esophageal,Neoplasm, Esophagus,Neoplasms, Esophagus
D005260 Female Females
D005472 Fluorouracil A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid. 5-FU,5-FU Lederle,5-FU Medac,5-Fluorouracil,5-Fluorouracil-Biosyn,5-HU Hexal,5FU,Adrucil,Carac,Efudex,Efudix,Fluoro-Uracile ICN,Fluoroplex,Fluorouracil Mononitrate,Fluorouracil Monopotassium Salt,Fluorouracil Monosodium Salt,Fluorouracil Potassium Salt,Fluorouracil-GRY,Fluorouracile Dakota,Fluorouracilo Ferrer Far,Fluoruracil,Fluracedyl,Flurodex,Haemato-FU,Neofluor,Onkofluor,Ribofluor,5 FU Lederle,5 FU Medac,5 Fluorouracil,5 Fluorouracil Biosyn,5 HU Hexal,Dakota, Fluorouracile,Fluoro Uracile ICN,Fluorouracil GRY,Haemato FU
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000077143 Docetaxel A semisynthetic analog of PACLITAXEL used in the treatment of locally advanced or metastatic BREAST NEOPLASMS and NON-SMALL CELL LUNG CANCER. Docetaxel Anhydrous,Docetaxel Hydrate,Docetaxel Trihydrate,Docetaxol,N-Debenzoyl-N-tert-butoxycarbonyl-10-deacetyltaxol,NSC 628503,RP 56976,RP-56976,Taxoltere Metro,Taxotere,N Debenzoyl N tert butoxycarbonyl 10 deacetyltaxol,RP56976
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly

Related Publications

Takeshi Shimakawa, and Yoshihiko Naritaka, and Shinichi Asaka, and Noriyuki Isohata, and Kentaro Yamaguchi, and Minoru Murayama, and Soichi Konno, and Takao Katsube, and Kenji Ogawa, and Hiroko Ide
The usefulness of neoadjuvant chemoradiation therapy for locally advanced esophageal cancer with multiple lymph-node metastases.
September 2014, Annals of surgical oncology,
Takeshi Shimakawa, and Yoshihiko Naritaka, and Shinichi Asaka, and Noriyuki Isohata, and Kentaro Yamaguchi, and Minoru Murayama, and Soichi Konno, and Takao Katsube, and Kenji Ogawa, and Hiroko Ide
[Long-Term Complete Response in Postoperative Multiple Lung and Mediastinal Lymph Node Metastases of Esophageal Cancer Using Systemic Chemotherapy with DCF Treatment - A Case Report].
January 2017, Gan to kagaku ryoho. Cancer & chemotherapy,
Takeshi Shimakawa, and Yoshihiko Naritaka, and Shinichi Asaka, and Noriyuki Isohata, and Kentaro Yamaguchi, and Minoru Murayama, and Soichi Konno, and Takao Katsube, and Kenji Ogawa, and Hiroko Ide
[A Case of Advanced Gastric Cancer with Multiple Bone Metastases, Virchow Lymph Node and Para-Aortic Lymph Node Metastases That Responded to Combined Modality Therapy and Underwent Conversion Surgery].
October 2018, Gan to kagaku ryoho. Cancer & chemotherapy,
Takeshi Shimakawa, and Yoshihiko Naritaka, and Shinichi Asaka, and Noriyuki Isohata, and Kentaro Yamaguchi, and Minoru Murayama, and Soichi Konno, and Takao Katsube, and Kenji Ogawa, and Hiroko Ide
[Pathological Complete Response in a Case of Advanced Esophageal Cancer with Widespread Lymph Node Metastases Treated Using Preoperative Chemotherapy with Docetaxel, Cisplatin, and 5-FU(DCF therapy)].
November 2016, Gan to kagaku ryoho. Cancer & chemotherapy,
Takeshi Shimakawa, and Yoshihiko Naritaka, and Shinichi Asaka, and Noriyuki Isohata, and Kentaro Yamaguchi, and Minoru Murayama, and Soichi Konno, and Takao Katsube, and Kenji Ogawa, and Hiroko Ide
[A Case of Lymph Node Metastases from Esophageal Cancer Successfully Treated with Weekly Paclitaxel Chemotherapy].
November 2015, Gan to kagaku ryoho. Cancer & chemotherapy,
Takeshi Shimakawa, and Yoshihiko Naritaka, and Shinichi Asaka, and Noriyuki Isohata, and Kentaro Yamaguchi, and Minoru Murayama, and Soichi Konno, and Takao Katsube, and Kenji Ogawa, and Hiroko Ide
Sentinel lymph node in esophageal cancer before neoadjuvant therapy.
June 2005, Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia,
Takeshi Shimakawa, and Yoshihiko Naritaka, and Shinichi Asaka, and Noriyuki Isohata, and Kentaro Yamaguchi, and Minoru Murayama, and Soichi Konno, and Takao Katsube, and Kenji Ogawa, and Hiroko Ide
Addition of bevacizumab to neoadjuvant chemotherapy for Stage IV ovarian serous adenocarcinoma with multiple lymph node metastases: a case report.
January 2015, European journal of gynaecological oncology,
Takeshi Shimakawa, and Yoshihiko Naritaka, and Shinichi Asaka, and Noriyuki Isohata, and Kentaro Yamaguchi, and Minoru Murayama, and Soichi Konno, and Takao Katsube, and Kenji Ogawa, and Hiroko Ide
[A case of gastric cancer with abdominal para-aortic lymph node metastases responding to TS-1 + CDDP neoadjuvant chemotherapy].
August 2005, Gan to kagaku ryoho. Cancer & chemotherapy,
Takeshi Shimakawa, and Yoshihiko Naritaka, and Shinichi Asaka, and Noriyuki Isohata, and Kentaro Yamaguchi, and Minoru Murayama, and Soichi Konno, and Takao Katsube, and Kenji Ogawa, and Hiroko Ide
[A case of gastric cancer with abdominal paraaortic lymph node metastases responding to TS-1 plus CDDP neoadjuvant chemotherapy].
October 2004, Gan to kagaku ryoho. Cancer & chemotherapy,
Takeshi Shimakawa, and Yoshihiko Naritaka, and Shinichi Asaka, and Noriyuki Isohata, and Kentaro Yamaguchi, and Minoru Murayama, and Soichi Konno, and Takao Katsube, and Kenji Ogawa, and Hiroko Ide
[A Case of Nivolumab Responding to Multiple Lymph Node Metastases during Multidisciplinary Treatment for Esophageal Cancer].
December 2022, Gan to kagaku ryoho. Cancer & chemotherapy,
Copied contents to your clipboard!