Oxidative stress status and lipid profiles of diabetic pregnant rats exposed to cigarette smoke. 2010

Maricelma da Silva Soares de Souza, and Yuri Karen Sinzato, and Paula Helena Ortiz Lima, and Iracema Mattos Paranhos Calderon, and Marilza Vieira Cunha Rudge, and Débora Cristina Damasceno
Laboratory of Experimental Research of Gynecology and Obstetrics, Department of Gynecology and Obstetrics, Botucatu Medical School, UNESP/Univ Estadual Paulista, São Paulo State, Brazil.

This study aimed to evaluate the oxidative stress status and the concentrations of triglycerides, cholesterol and total proteins of pregnant rats exposed to the association of diabetes and cigarette smoke. Female Wistar rats were randomly distributed in four experimental groups, according to presence or not of diabetes and the exposure or not to cigarette smoke. Diabetes was induced by streptozotocin (40 mg/kg i.v.) and exposure to cigarette smoke was for 30 min, twice a day, for 2 months. At day 21 of pregnancy, blood was collected for total protein, triglyceride, cholesterol and oxidative stress determinations. Data were analysed by ANOVA followed by Student-Newman-Keuls test (P<0.05). The association of diabetes and exposure to cigarette smoke was related to the incidence of hypertriglyceridaemia, and this result was due to the severe diabetes and not to exposure to smoke. There was no alteration to protein metabolism in pregnant rats. Diabetes and cigarette smoke exposure led to the activation of the antioxidant system in an attempt to detoxify the organism in face of high lipid peroxidation, which can be characterized by the determination of reactive substances to thiobarbituric acid.

UI MeSH Term Description Entries
D008055 Lipids A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed) Lipid
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D011254 Pregnancy in Diabetics The state of PREGNANCY in women with DIABETES MELLITUS. This does not include either symptomatic diabetes or GLUCOSE INTOLERANCE induced by pregnancy (DIABETES, GESTATIONAL) which resolves at the end of pregnancy. Pregnancy in Diabetes,Pregnancy in Diabete,Pregnancy in Diabetic
D002784 Cholesterol The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils. Epicholesterol
D003921 Diabetes Mellitus, Experimental Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY. Alloxan Diabetes,Streptozocin Diabetes,Streptozotocin Diabetes,Experimental Diabetes Mellitus,Diabete, Streptozocin,Diabetes, Alloxan,Diabetes, Streptozocin,Diabetes, Streptozotocin,Streptozocin Diabete
D005260 Female Females
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012906 Smoke Visible gaseous suspension of carbon and other particulate matter emitted from burning substances.
D012907 Smoking Willful or deliberate act of inhaling and exhaling SMOKE from burning substances or agents held by hand. Smoking Behaviors,Smoking Habit,Behavior, Smoking,Behaviors, Smoking,Habit, Smoking,Habits, Smoking,Smoking Behavior,Smoking Habits
D014028 Tobacco Smoke Pollution Contamination of the air by tobacco smoke. Air Pollution, Tobacco Smoke,Environmental Pollution, Tobacco Smoke,Passive Smoking,Smoking, Passive,Environmental Smoke Pollution, Tobacco,Environmental Tobacco Smoke Pollution,Involuntary Smoking,Second Hand Smoke,Secondhand Smoke,Secondhand Smoking,Hand Smoke, Second,Hand Smokes, Second,Involuntary Smokings,Passive Smokings,Pollution, Tobacco Smoke,Pollutions, Tobacco Smoke,Second Hand Smokes,Secondhand Smokes,Secondhand Smokings,Smoke Pollution, Tobacco,Smoke Pollutions, Tobacco,Smoke, Second Hand,Smoke, Secondhand,Smokes, Second Hand,Smokes, Secondhand,Smoking, Involuntary,Smoking, Secondhand,Smokings, Involuntary,Smokings, Passive,Smokings, Secondhand,Tobacco Smoke Pollutions

Related Publications

Maricelma da Silva Soares de Souza, and Yuri Karen Sinzato, and Paula Helena Ortiz Lima, and Iracema Mattos Paranhos Calderon, and Marilza Vieira Cunha Rudge, and Débora Cristina Damasceno
September 2019, Reproductive sciences (Thousand Oaks, Calif.),
Maricelma da Silva Soares de Souza, and Yuri Karen Sinzato, and Paula Helena Ortiz Lima, and Iracema Mattos Paranhos Calderon, and Marilza Vieira Cunha Rudge, and Débora Cristina Damasceno
July 1998, Free radical biology & medicine,
Maricelma da Silva Soares de Souza, and Yuri Karen Sinzato, and Paula Helena Ortiz Lima, and Iracema Mattos Paranhos Calderon, and Marilza Vieira Cunha Rudge, and Débora Cristina Damasceno
June 2019, Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria,
Maricelma da Silva Soares de Souza, and Yuri Karen Sinzato, and Paula Helena Ortiz Lima, and Iracema Mattos Paranhos Calderon, and Marilza Vieira Cunha Rudge, and Débora Cristina Damasceno
June 2019, Journal of periodontal research,
Maricelma da Silva Soares de Souza, and Yuri Karen Sinzato, and Paula Helena Ortiz Lima, and Iracema Mattos Paranhos Calderon, and Marilza Vieira Cunha Rudge, and Débora Cristina Damasceno
August 2006, American journal of respiratory and critical care medicine,
Maricelma da Silva Soares de Souza, and Yuri Karen Sinzato, and Paula Helena Ortiz Lima, and Iracema Mattos Paranhos Calderon, and Marilza Vieira Cunha Rudge, and Débora Cristina Damasceno
June 2015, Molecular medicine reports,
Maricelma da Silva Soares de Souza, and Yuri Karen Sinzato, and Paula Helena Ortiz Lima, and Iracema Mattos Paranhos Calderon, and Marilza Vieira Cunha Rudge, and Débora Cristina Damasceno
February 1995, Journal of biochemical toxicology,
Maricelma da Silva Soares de Souza, and Yuri Karen Sinzato, and Paula Helena Ortiz Lima, and Iracema Mattos Paranhos Calderon, and Marilza Vieira Cunha Rudge, and Débora Cristina Damasceno
July 2012, Experimental and therapeutic medicine,
Maricelma da Silva Soares de Souza, and Yuri Karen Sinzato, and Paula Helena Ortiz Lima, and Iracema Mattos Paranhos Calderon, and Marilza Vieira Cunha Rudge, and Débora Cristina Damasceno
August 2010, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society,
Maricelma da Silva Soares de Souza, and Yuri Karen Sinzato, and Paula Helena Ortiz Lima, and Iracema Mattos Paranhos Calderon, and Marilza Vieira Cunha Rudge, and Débora Cristina Damasceno
January 2005, Pharmacological reports : PR,
Copied contents to your clipboard!