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In this work we have quantified soluble class I histocompatibility antigens (s-HLA) and beta 2-microglobulin (beta 2 m) in sera of HIV+ or HIV- mothers at delivery and in cord blood sera of their newborn children. The results obtained for beta 2 m show that cord blood sera of newborn children have higher concentrations than their mothers, implying that most of the beta 2 m in the newborn is self-produced as described previously. s-HLA serum concentrations in the newborn children are significantly lower than in their mothers or in age-matched controls. Moreover, HIV+ mothers have significantly higher serum concentrations than HIV- mothers or an age-matched control group. These results suggest that s-HLA does not cross the placental barrier.
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P Gonzalez-Porqué, and
G Fontán
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January 1989,
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M C García Rodríguez, and
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G Fontán
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G Fontán
January 1984,
Experimental and clinical immunogenetics,
A Ferreira, and
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G Fontán
January 1987,
Immunogenetics,
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A Ferreira, and
M C García Rodríguez, and
F Omeñaca, and
A Jiménez, and
L M Villar, and
P Gonzalez-Porqué, and
G Fontán
September 1993,
Journal of immunology (Baltimore, Md. : 1950),
A Ferreira, and
M C García Rodríguez, and
F Omeñaca, and
A Jiménez, and
L M Villar, and
P Gonzalez-Porqué, and
G Fontán
July 1994,
Human immunology,
A Ferreira, and
M C García Rodríguez, and
F Omeñaca, and
A Jiménez, and
L M Villar, and
P Gonzalez-Porqué, and
G Fontán
January 1994,
Vox sanguinis,
A Ferreira, and
M C García Rodríguez, and
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A Jiménez, and
L M Villar, and
P Gonzalez-Porqué, and
G Fontán
March 1986,
Tissue antigens,
