Biomaterial Database

[Antileukotrienes in asthma - critical view]. 2010

Wacław Droszcz

This article discusses the role of cysteinyl leukotrienes in asthma and addresses the problem of the use of leukotriene receptor antagonists (LTRA) in the treatment of asthma. The author points out that these drugs are inferior to inhaled corticosteroids and long acting beta agonists and should be used as "add on" drugs being a third choice in the management of asthma. Lack of response to LTRA has a genetic background. Side effects of LTRA therapy is discussed, particularly Churg-Strauss syndrome. According to the recent literature, LTRA monotherapy should not be applied. In general, the author suggests that there is a risk of LTRA overtreatment particularly in children.

UI	MeSH Term	Description	Entries
D001993	Bronchodilator Agents	Agents that cause an increase in the expansion of a bronchus or bronchial tubes.	Bronchial-Dilating Agents,Bronchodilator,Bronchodilator Agent,Broncholytic Agent,Bronchodilator Effect,Bronchodilator Effects,Bronchodilators,Broncholytic Agents,Broncholytic Effect,Broncholytic Effects,Agent, Bronchodilator,Agent, Broncholytic,Agents, Bronchial-Dilating,Agents, Bronchodilator,Agents, Broncholytic,Bronchial Dilating Agents,Effect, Bronchodilator,Effect, Broncholytic,Effects, Bronchodilator,Effects, Broncholytic
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D004347	Drug Interactions	The action of a drug that may affect the activity, metabolism, or toxicity of another drug.	Drug Interaction,Interaction, Drug,Interactions, Drug
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000085	Acetates	Derivatives of ACETIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the carboxymethane structure.	Acetate,Acetic Acid Esters,Acetic Acids,Acids, Acetic,Esters, Acetic Acid
D000305	Adrenal Cortex Hormones	HORMONES produced by the ADRENAL CORTEX, including both steroid and peptide hormones. The major hormones produced are HYDROCORTISONE and ALDOSTERONE.	Adrenal Cortex Hormone,Corticoid,Corticoids,Corticosteroid,Corticosteroids,Cortex Hormone, Adrenal,Hormone, Adrenal Cortex,Hormones, Adrenal Cortex
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D001249	Asthma	A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).	Asthma, Bronchial,Bronchial Asthma,Asthmas
D015267	Churg-Strauss Syndrome	Widespread necrotizing angiitis with granulomas. Pulmonary involvement is frequent. Asthma or other respiratory infection may precede evidence of vasculitis. Eosinophilia and lung involvement differentiate this disease from POLYARTERITIS NODOSA.	Allergic Angiitis,Allergic Granulomatous Angiitis,Angiitis, Allergic Granulomatous,EGPA Disorder,Eosinophilic Granulomatosis with Polyangiitis,Vasculitis, Churg-Strauss,Allergic Angiitis and Granulomatosis,Allergic Granulomatosis,Allergic Granulomatous and Angiitis,Eosinophilic Granulomatous Vasculitis,Granulomatous Allergic Angiitis,Allergic Angiitides,Allergic Angiitides, Granulomatous,Allergic Angiitis, Granulomatous,Allergic Granulomatoses,Allergic Granulomatous Angiitides,Angiitides, Allergic,Angiitides, Allergic Granulomatous,Angiitides, Granulomatous Allergic,Angiitis, Allergic,Angiitis, Granulomatous Allergic,Churg Strauss Syndrome,Churg-Strauss Vasculitis,Disorder, EGPA,Disorders, EGPA,EGPA Disorders,Granulomatoses, Allergic,Granulomatosis, Allergic,Granulomatous Allergic Angiitides,Granulomatous Angiitides, Allergic,Granulomatous Angiitis, Allergic,Granulomatous Vasculitides, Eosinophilic,Granulomatous Vasculitis, Eosinophilic,Syndrome, Churg-Strauss,Vasculitides, Eosinophilic Granulomatous,Vasculitis, Churg Strauss,Vasculitis, Eosinophilic Granulomatous
D015289	Leukotrienes	A family of biologically active compounds derived from arachidonic acid by oxidative metabolism through the 5-lipoxygenase pathway. They participate in host defense reactions and pathophysiological conditions such as immediate hypersensitivity and inflammation. They have potent actions on many essential organs and systems, including the cardiovascular, pulmonary, and central nervous system as well as the gastrointestinal tract and the immune system.	Leukotriene