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Erlotinib is a newly developed molecular-targeting or molecular-targeted drug with selective inhibitory activity for tyrosine kinase of the epidermal growth factor receptor. A adverse drug reactions including diarrhea, skin eruptions are considered mild. We report a case of recurrent adenocarcinoma of the lung in a 68-year-old woman who suffered from Henoch-Schönlein purpura induced by erlotinib. She received daily administration of erlotinib 150 mg as second-line chemotherapy. Her tumors decreased in size and pleural effusion disappeared, so we considered erlotinib effective. However after 3 months of treatment with erlotinib, the patient presented palpable purpuric lesions mostly located on her lower legs. We diagnosed Henoch-Schönlein purpura based on skin histological findings. Erlotinib was reduced but continued, with improvement of the eruptions. Henoch-Schönlein purpura is often accompanied by systemic manifestations, such as renal disease and arthritis, so more careful follow-up is warranted.
Tatsuya Yuba, and
Kazuhiro Nagata, and
Shinsuke Shiotsu, and
Akira Okano, and
Mayumi Hatsuse, and
Satoshi Murakami, and
Kiyoshi Morihara, and
Chihiro Shimazaki
April 2012,
Journal of medical case reports,
Tatsuya Yuba, and
Kazuhiro Nagata, and
Shinsuke Shiotsu, and
Akira Okano, and
Mayumi Hatsuse, and
Satoshi Murakami, and
Kiyoshi Morihara, and
Chihiro Shimazaki
November 1976,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
Tatsuya Yuba, and
Kazuhiro Nagata, and
Shinsuke Shiotsu, and
Akira Okano, and
Mayumi Hatsuse, and
Satoshi Murakami, and
Kiyoshi Morihara, and
Chihiro Shimazaki
April 2008,
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego,
Tatsuya Yuba, and
Kazuhiro Nagata, and
Shinsuke Shiotsu, and
Akira Okano, and
Mayumi Hatsuse, and
Satoshi Murakami, and
Kiyoshi Morihara, and
Chihiro Shimazaki
February 2018,
Revista chilena de pediatria,
Tatsuya Yuba, and
Kazuhiro Nagata, and
Shinsuke Shiotsu, and
Akira Okano, and
Mayumi Hatsuse, and
Satoshi Murakami, and
Kiyoshi Morihara, and
Chihiro Shimazaki
January 2014,
Revue medicale de Bruxelles,
Tatsuya Yuba, and
Kazuhiro Nagata, and
Shinsuke Shiotsu, and
Akira Okano, and
Mayumi Hatsuse, and
Satoshi Murakami, and
Kiyoshi Morihara, and
Chihiro Shimazaki
February 2016,
Archives of disease in childhood,
Tatsuya Yuba, and
Kazuhiro Nagata, and
Shinsuke Shiotsu, and
Akira Okano, and
Mayumi Hatsuse, and
Satoshi Murakami, and
Kiyoshi Morihara, and
Chihiro Shimazaki
May 1980,
Journal of oral surgery (American Dental Association : 1965),
Tatsuya Yuba, and
Kazuhiro Nagata, and
Shinsuke Shiotsu, and
Akira Okano, and
Mayumi Hatsuse, and
Satoshi Murakami, and
Kiyoshi Morihara, and
Chihiro Shimazaki
February 2010,
Pediatrics and neonatology,
Tatsuya Yuba, and
Kazuhiro Nagata, and
Shinsuke Shiotsu, and
Akira Okano, and
Mayumi Hatsuse, and
Satoshi Murakami, and
Kiyoshi Morihara, and
Chihiro Shimazaki
September 1999,
International journal of dermatology,
Tatsuya Yuba, and
Kazuhiro Nagata, and
Shinsuke Shiotsu, and
Akira Okano, and
Mayumi Hatsuse, and
Satoshi Murakami, and
Kiyoshi Morihara, and
Chihiro Shimazaki
September 1994,
The British journal of dermatology,
