BIOMAT Database Logo BIOMAT Database Logo

High-dose intravenous levetiracetam for acute seizure exacerbation in children with intractable epilepsy. 2010

Dewi T Depositario-Cabacar, and Jurriaan M Peters, and Amanda W Pong, and Julie Roth, and Alexander Rotenberg, and James J Riviello, and Masanori Takeoka
Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Children's Hospital Boston, Massachusetts, USA.

We review our experience with high-dose intravenous levetiracetam (IV-LEV) for acute seizure exacerbations in nine children with medically intractable epilepsy. All children had acute repetitive seizures-while on chronic antiepileptic drugs-that either led to hospitalization (eight) or occurred during hospitalization (one), and received doses of IV-LEV of 150 mg/kg/day or greater, with a mean dose of 228 +/- 48 mg/kg/day. Eight of nine children had resolution of the acute repetitive seizures. Seizure frequency was reduced to less than baseline in seven children (seizure-free in two, >/=80% reduction in four, and 50% reduction in one). Except for one child with increased seizures, IV-LEV was well tolerated in all children without complications.

UI MeSH Term Description Entries
D007223 Infant A child between 1 and 23 months of age. Infants
D007275 Injections, Intravenous Injections made into a vein for therapeutic or experimental purposes. Intravenous Injections,Injection, Intravenous,Intravenous Injection
D008297 Male Males
D010889 Piracetam A compound suggested to be both a nootropic and a neuroprotective agent. 2-Pyrrolidone-N-Acetamide,Avigilen,Axonyl,Cerebroforte,Cerepar N,Ciclofalina,Cuxabrain,Dinagen,Gabacet,Geram,Memo-Puren,Nootrop,Nootropil,Nootropyl,Normabraïn,Piracebral,Piracetam AbZ,Piracetam-RPh,Piracetrop,Pirazetam,Pyracetam,Pyramem,Sinapsan,UCB-6215,Memo Puren,Piracetam RPh,UCB 6215,UCB6215
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D004827 Epilepsy A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313) Aura,Awakening Epilepsy,Seizure Disorder,Epilepsy, Cryptogenic,Auras,Cryptogenic Epilepsies,Cryptogenic Epilepsy,Epilepsies,Epilepsies, Cryptogenic,Epilepsy, Awakening,Seizure Disorders
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000077287 Levetiracetam A pyrrolidinone and acetamide derivative that is used primarily for the treatment of SEIZURES and some movement disorders, and as a nootropic agent. Etiracetam,Etiracetam, (R)-,Etiracetam, R-isomer,Etiracetam, S-isomer,Keppra,UCB 6474,UCB-6474,Ucb L059,Ucb L060,Ucb-L059,Ucb-L060,alpha-ethyl-2-oxo-1-Pyrrolidineacetamide,Etiracetam, R isomer,Etiracetam, S isomer,R-isomer Etiracetam,S-isomer Etiracetam,UCB6474,UcbL060,alpha ethyl 2 oxo 1 Pyrrolidineacetamide

Related Publications

Dewi T Depositario-Cabacar, and Jurriaan M Peters, and Amanda W Pong, and Julie Roth, and Alexander Rotenberg, and James J Riviello, and Masanori Takeoka
Intravenous high-dose gammaglobulins for intractable childhood epilepsy.
September 1993, Acta neurologica Scandinavica,
Dewi T Depositario-Cabacar, and Jurriaan M Peters, and Amanda W Pong, and Julie Roth, and Alexander Rotenberg, and James J Riviello, and Masanori Takeoka
Intravenous levetiracetam in children with epilepsy.
March 2008, Pediatric neurology,
Dewi T Depositario-Cabacar, and Jurriaan M Peters, and Amanda W Pong, and Julie Roth, and Alexander Rotenberg, and James J Riviello, and Masanori Takeoka
Seizure precipitants in children with intractable epilepsy.
September 2008, Brain & development,
Dewi T Depositario-Cabacar, and Jurriaan M Peters, and Amanda W Pong, and Julie Roth, and Alexander Rotenberg, and James J Riviello, and Masanori Takeoka
Role of intravenous levetiracetam in acute seizure management of children.
July 2009, Pediatric neurology,
Dewi T Depositario-Cabacar, and Jurriaan M Peters, and Amanda W Pong, and Julie Roth, and Alexander Rotenberg, and James J Riviello, and Masanori Takeoka
High dose intravenous gamma-globulin in intractable epilepsy of childhood.
July 1991, European journal of pediatrics,
Dewi T Depositario-Cabacar, and Jurriaan M Peters, and Amanda W Pong, and Julie Roth, and Alexander Rotenberg, and James J Riviello, and Masanori Takeoka
Role of intravenous levetiracetam in acute seizure management.
January 2014, Frontiers in neurology,
Dewi T Depositario-Cabacar, and Jurriaan M Peters, and Amanda W Pong, and Julie Roth, and Alexander Rotenberg, and James J Riviello, and Masanori Takeoka
Role of intravenous levetiracetam for acute seizure management in preterm neonates.
November 2013, Pediatric neurology,
Dewi T Depositario-Cabacar, and Jurriaan M Peters, and Amanda W Pong, and Julie Roth, and Alexander Rotenberg, and James J Riviello, and Masanori Takeoka
Seizure outcome of intractable partial epilepsy in children.
April 2002, Pediatric neurology,
Dewi T Depositario-Cabacar, and Jurriaan M Peters, and Amanda W Pong, and Julie Roth, and Alexander Rotenberg, and James J Riviello, and Masanori Takeoka
Retention rate of levetiracetam in children with intractable epilepsy at 1 year.
March 2007, Seizure,
Dewi T Depositario-Cabacar, and Jurriaan M Peters, and Amanda W Pong, and Julie Roth, and Alexander Rotenberg, and James J Riviello, and Masanori Takeoka
High dose gammaglobulin for intractable childhood epilepsy.
July 1983, Lancet (London, England),
Copied contents to your clipboard!