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We investigated the effect of hyperthermic pretreatment before induction of ischemia using a gerbil model of 5-min forebrain ischemia. A single hyperthermic treatment 18 h before ischemia exhibited a partial protective effect, and repetitive hyperthermic pretreatments at 18-h intervals before ischemia showed clear protection against neuronal death in the CA1 area of the hippocampus, whereas single hyperthermic treatment 3, 6, 24, or 50 h before ischemia exhibited little protective effect. This transient and cumulative neuroprotective effect of hyperthermic pretreatment strongly suggested the involvement of stress reactions after hyperthermia in the protective mechanism against ischemic neuronal death.
K Kitagawa, and
M Matsumoto, and
M Tagaya, and
K Kuwabara, and
R Hata, and
N Handa, and
R Fukunaga, and
K Kimura, and
T Kamada
December 1988,
Stroke,
K Kitagawa, and
M Matsumoto, and
M Tagaya, and
K Kuwabara, and
R Hata, and
N Handa, and
R Fukunaga, and
K Kimura, and
T Kamada
July 1990,
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism,
K Kitagawa, and
M Matsumoto, and
M Tagaya, and
K Kuwabara, and
R Hata, and
N Handa, and
R Fukunaga, and
K Kimura, and
T Kamada
January 2004,
Journal of neurosurgical anesthesiology,
K Kitagawa, and
M Matsumoto, and
M Tagaya, and
K Kuwabara, and
R Hata, and
N Handa, and
R Fukunaga, and
K Kimura, and
T Kamada
December 2002,
Brain research,
K Kitagawa, and
M Matsumoto, and
M Tagaya, and
K Kuwabara, and
R Hata, and
N Handa, and
R Fukunaga, and
K Kimura, and
T Kamada
April 2007,
Pharmacological research,
K Kitagawa, and
M Matsumoto, and
M Tagaya, and
K Kuwabara, and
R Hata, and
N Handa, and
R Fukunaga, and
K Kimura, and
T Kamada
October 2014,
Inflammation,
K Kitagawa, and
M Matsumoto, and
M Tagaya, and
K Kuwabara, and
R Hata, and
N Handa, and
R Fukunaga, and
K Kimura, and
T Kamada
January 1993,
Cerebrovascular and brain metabolism reviews,
K Kitagawa, and
M Matsumoto, and
M Tagaya, and
K Kuwabara, and
R Hata, and
N Handa, and
R Fukunaga, and
K Kimura, and
T Kamada
April 1986,
Journal of neurosurgery,
K Kitagawa, and
M Matsumoto, and
M Tagaya, and
K Kuwabara, and
R Hata, and
N Handa, and
R Fukunaga, and
K Kimura, and
T Kamada
March 2009,
Journal of pharmacological sciences,
K Kitagawa, and
M Matsumoto, and
M Tagaya, and
K Kuwabara, and
R Hata, and
N Handa, and
R Fukunaga, and
K Kimura, and
T Kamada
June 2000,
Neurochemical research,
