Effects of central administration of glucagon on feed intake and endocrine responses in sheep. 2009

Yohei Kurose, and Hiroshi Kamisoyama, and Kazuhisa Honda, and Yoshiyuki Azuma, and Kunio Sugahara, and Shin Hasegawa, and Shigeki Kobayashi
Laboratory of Animal Nutrition, Faculty of Animal Science, Kitasato University, Towada, Aomori, Japan. kurose@vmas.kitasato-u.ac.jp

This study was conducted to investigate effects of glucagon intracerebroventricularly administered on feed intake and endocrine changes in sheep. Four male sheep (48-55 kg BW) were used. The animals were acclimatized to be fed alfalfa hay cubes at 12.00 hour. Human glucagon (40 and 80 microg/0.5 mL) was injected into the lateral ventricle at 12.00 hour. Blood samples were taken every 10 min from 30 min before to 180 min after the glucagon injection. Soon after the injection, the animals were given alfalfa hay cubes, and the amounts of the feed eaten within 2 h were measured. Feed intakes were significantly (P < 0.05) suppressed by 80 microg of glucagon. Plasma glucose levels in control animals were gradually decreased after the feeding, whilst those in glucagon-treated animals were temporarily elevated just after the feeding and then kept higher than control levels. Plasma insulin was abruptly elevated after the feeding and was maintained at higher levels than before the feeding in all treatments. Plasma NEFA concentrations were decreased after the feeding in all treatments. A tendency of increase in plasma cortisol levels occurred in glucagon-injected animals. The present study provides the first evidence that glucagon directly acts on the brain, then inhibiting feeding behavior and inducing endocrine responses in ruminants.

UI MeSH Term Description Entries
D007267 Injections Introduction of substances into the body using a needle and syringe. Injectables,Injectable,Injection
D007328 Insulin A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1). Iletin,Insulin A Chain,Insulin B Chain,Insulin, Regular,Novolin,Sodium Insulin,Soluble Insulin,Chain, Insulin B,Insulin, Sodium,Insulin, Soluble,Regular Insulin
D008297 Male Males
D001921 Brain The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM. Encephalon
D002552 Cerebral Ventricles Four CSF-filled (see CEREBROSPINAL FLUID) cavities within the cerebral hemispheres (LATERAL VENTRICLES), in the midline (THIRD VENTRICLE) and within the PONS and MEDULLA OBLONGATA (FOURTH VENTRICLE). Foramen of Monro,Cerebral Ventricular System,Cerebral Ventricle,Cerebral Ventricular Systems,Monro Foramen,System, Cerebral Ventricular,Systems, Cerebral Ventricular,Ventricle, Cerebral,Ventricles, Cerebral,Ventricular System, Cerebral,Ventricular Systems, Cerebral
D004435 Eating The consumption of edible substances. Dietary Intake,Feed Intake,Food Intake,Macronutrient Intake,Micronutrient Intake,Nutrient Intake,Nutritional Intake,Ingestion,Dietary Intakes,Feed Intakes,Intake, Dietary,Intake, Feed,Intake, Food,Intake, Macronutrient,Intake, Micronutrient,Intake, Nutrient,Intake, Nutritional,Macronutrient Intakes,Micronutrient Intakes,Nutrient Intakes,Nutritional Intakes
D005230 Fatty Acids, Nonesterified FATTY ACIDS found in the plasma that are complexed with SERUM ALBUMIN for transport. These fatty acids are not in glycerol ester form. Fatty Acids, Free,Free Fatty Acid,Free Fatty Acids,NEFA,Acid, Free Fatty,Acids, Free Fatty,Acids, Nonesterified Fatty,Fatty Acid, Free,Nonesterified Fatty Acids
D005934 Glucagon A 29-amino acid pancreatic peptide derived from proglucagon which is also the precursor of intestinal GLUCAGON-LIKE PEPTIDES. Glucagon is secreted by PANCREATIC ALPHA CELLS and plays an important role in regulation of BLOOD GLUCOSE concentration, ketone metabolism, and several other biochemical and physiological processes. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1511) Glucagon (1-29),Glukagon,HG-Factor,Hyperglycemic-Glycogenolytic Factor,Proglucagon (33-61),HG Factor,Hyperglycemic Glycogenolytic Factor
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006854 Hydrocortisone The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions. Cortef,Cortisol,Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-,11-Epicortisol,Cortifair,Cortril,Epicortisol,Hydrocortisone, (11 alpha)-Isomer,Hydrocortisone, (9 beta,10 alpha,11 alpha)-Isomer,11 Epicortisol

Related Publications

Yohei Kurose, and Hiroshi Kamisoyama, and Kazuhisa Honda, and Yoshiyuki Azuma, and Kunio Sugahara, and Shin Hasegawa, and Shigeki Kobayashi
August 1981, Journal of animal science,
Yohei Kurose, and Hiroshi Kamisoyama, and Kazuhisa Honda, and Yoshiyuki Azuma, and Kunio Sugahara, and Shin Hasegawa, and Shigeki Kobayashi
July 2004, Journal of animal science,
Yohei Kurose, and Hiroshi Kamisoyama, and Kazuhisa Honda, and Yoshiyuki Azuma, and Kunio Sugahara, and Shin Hasegawa, and Shigeki Kobayashi
July 1970, Journal of animal science,
Yohei Kurose, and Hiroshi Kamisoyama, and Kazuhisa Honda, and Yoshiyuki Azuma, and Kunio Sugahara, and Shin Hasegawa, and Shigeki Kobayashi
December 2019, Journal of animal science,
Yohei Kurose, and Hiroshi Kamisoyama, and Kazuhisa Honda, and Yoshiyuki Azuma, and Kunio Sugahara, and Shin Hasegawa, and Shigeki Kobayashi
January 2023, Journal of animal science,
Yohei Kurose, and Hiroshi Kamisoyama, and Kazuhisa Honda, and Yoshiyuki Azuma, and Kunio Sugahara, and Shin Hasegawa, and Shigeki Kobayashi
December 2015, Journal of animal science,
Yohei Kurose, and Hiroshi Kamisoyama, and Kazuhisa Honda, and Yoshiyuki Azuma, and Kunio Sugahara, and Shin Hasegawa, and Shigeki Kobayashi
November 1984, Journal of animal science,
Yohei Kurose, and Hiroshi Kamisoyama, and Kazuhisa Honda, and Yoshiyuki Azuma, and Kunio Sugahara, and Shin Hasegawa, and Shigeki Kobayashi
May 2024, Tropical animal health and production,
Yohei Kurose, and Hiroshi Kamisoyama, and Kazuhisa Honda, and Yoshiyuki Azuma, and Kunio Sugahara, and Shin Hasegawa, and Shigeki Kobayashi
October 1980, The Journal of nutrition,
Yohei Kurose, and Hiroshi Kamisoyama, and Kazuhisa Honda, and Yoshiyuki Azuma, and Kunio Sugahara, and Shin Hasegawa, and Shigeki Kobayashi
May 1971, The Proceedings of the Nutrition Society,
Copied contents to your clipboard!