This epidemiological-descriptive study aimed to describe the temporal evolution of dengue cases in Ribeirão Preto, São Paulo State, between 1994 and 2003, according to month of occurrence and gender. Data were obtained from the compulsory notification forms provided by the Epidemiological Surveillance service of the Ribeirão Preto Municipal Health Secretary. We obtained incidence coefficients per 100,000 inhabitants, according to population estimates by the Brazilian Institute of Geography and Statistics. The city experienced a dengue epidemic in 2001, when the incidence coefficient reached 619.65 cases/100,000 inhabitants. We found 5553 cases during the study period, 0.07% of which occurred in 1994, 3.68% in 1995, 4.52% in 1996, 2.40% in 1997, 1.82% in 1998, 5.73% in 1999, 3.75% in 2000, 57.37% in 2001, 6.25% in 2002 and 14.39% in 2003. January to May were the months with the highest occurrence levels. As to the gender variable, we found a proportion of approximately 1:1, showing small fluctuations between men and women for dengue cases during the entire study period. Results indicate the need to study the theme and reinforce the role of teaching institutions to tackle dengue in Brazil.