Biomaterial Database

[Thermoanalytical investigation of rat myometrium during gestation]. 2009

Gábor Csík, and Balázs Patzai, and György Falkay, and István Zupkó

Szegedi Tudományegyetem, Gyógyszerhatástani es Biofarmáciai Intézet, Szeged, Eötvös u. 6. -6720.

The aim of our present study was the investigation of rat myometrium by means of differential scanning calorimetry as a function of gestational age. Some additional groups of animals were exposed to adjuvant arthritis as a model for generalized inflammation. In order to find a connection between calorimetrically determined parameters and motor activity isolated organ experiments were performed and spontaneous as well as KCl-stimulated contractility were recorded. Uterine rings from the 5th day of early pregnancy (days 3-6) exhibited a maximum motor activity. A close correlation was revealed between calorimetric enthalpy (deltaH value) and basal and stimulated contractility. The generalized inflammation increased the maximal contractions at all tested stages (non pregnant, days 14 and 21). As gestation progressed deltaH value increased in control rats but not in animals exposed to inflammation. Our results indicate that calorimetric technique is suitable for functional investigation of pregnancy-induced or disease-related changes of myometrial samples.

UI	MeSH Term	Description	Entries
D009043	Motor Activity	Body movements of a human or an animal as a behavioral phenomenon.	Activities, Motor,Activity, Motor,Motor Activities
D009119	Muscle Contraction	A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.	Inotropism,Muscular Contraction,Contraction, Muscle,Contraction, Muscular,Contractions, Muscle,Contractions, Muscular,Inotropisms,Muscle Contractions,Muscular Contractions
D009215	Myometrium	The smooth muscle coat of the uterus, which forms the main mass of the organ.	Uterine Muscle,Muscle, Uterine,Muscles, Uterine,Uterine Muscles
D011189	Potassium Chloride	A white crystal or crystalline powder used in BUFFERS; FERTILIZERS; and EXPLOSIVES. It can be used to replenish ELECTROLYTES and restore WATER-ELECTROLYTE BALANCE in treating HYPOKALEMIA.	Slow-K,Chloride, Potassium
D011247	Pregnancy	The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	Gestation,Pregnancies
D011270	Pregnancy, Animal	The process of bearing developing young (EMBRYOS or FETUSES) in utero in non-human mammals, beginning from FERTILIZATION to BIRTH.	Animal Pregnancies,Animal Pregnancy,Pregnancies, Animal
D002151	Calorimetry	The measurement of the quantity of heat involved in various processes, such as chemical reactions, changes of state, and formations of solutions, or in the determination of the heat capacities of substances. The fundamental unit of measurement is the joule or the calorie (4.184 joules). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
D005260	Female		Females
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus