BIOMAT Database Logo BIOMAT Database Logo

Corticotropin-releasing hormone inhibits maternal behavior and induces pup-killing. 1991

C A Pedersen, and J D Caldwell, and M McGuire, and D L Evans
Dept. Psychiatry, Univ. of North Carolina School of Medicine, Chapel Hill 27599-7160.

Behavioral responses to stressors and the effects of stressors on maternal behavior change with mothering experience. Corticotropin-releasing hormone (CRH) is released by stressors and produces stress-like behavioral effects. We tested the effects of ICV infusion of ovine CRH (0.5-4 ug) on pup-directed behaviors in ovariectomized, ovarian steroid-treated virgin rats that were either naive to pups or that had three days of mothering experience. CRH inhibited maternal behavior in naive and experienced rats in a dose-related manner. The magnitude and duration of inhibition, especially at the 1 ug dose, were less in rats with mothering experience. Higher doses of CRH (1 - 4 ug) significantly increased pup-killing in rats that were naive to pups. In contrast, CRH produced no pup-killing in rats with mothering experience.

UI MeSH Term Description Entries
D010052 Ovariectomy The surgical removal of one or both ovaries. Castration, Female,Oophorectomy,Bilateral Ovariectomy,Bilateral Ovariectomies,Castrations, Female,Female Castration,Female Castrations,Oophorectomies,Ovariectomies,Ovariectomies, Bilateral,Ovariectomy, Bilateral
D010053 Ovary The reproductive organ (GONADS) in female animals. In vertebrates, the ovary contains two functional parts: the OVARIAN FOLLICLE for the production of female germ cells (OOGENESIS); and the endocrine cells (GRANULOSA CELLS; THECA CELLS; and LUTEAL CELLS) for the production of ESTROGENS and PROGESTERONE. Ovaries
D011919 Rats, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding. August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D003346 Corticotropin-Releasing Hormone A peptide of about 41 amino acids that stimulates the release of ADRENOCORTICOTROPIC HORMONE. CRH is synthesized by neurons in the PARAVENTRICULAR NUCLEUS of the HYPOTHALAMUS. After being released into the pituitary portal circulation, CRH stimulates the release of ACTH from the PITUITARY GLAND. CRH can also be synthesized in other tissues, such as PLACENTA; ADRENAL MEDULLA; and TESTIS. ACTH-Releasing Hormone,CRF-41,Corticotropin-Releasing Factor,Corticotropin-Releasing Hormone-41,ACTH-Releasing Factor,CRF (ACTH),Corticoliberin,Corticotropin-Releasing Factor-41,ACTH Releasing Factor,ACTH Releasing Hormone,Corticotropin Releasing Factor,Corticotropin Releasing Factor 41,Corticotropin Releasing Hormone,Corticotropin Releasing Hormone 41
D005260 Female Females
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001522 Behavior, Animal The observable response an animal makes to any situation. Autotomy Animal,Animal Behavior,Animal Behaviors
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

C A Pedersen, and J D Caldwell, and M McGuire, and D L Evans
Postnatal pup brain dopamine depletion inhibits maternal behavior.
December 1997, Pharmacology, biochemistry, and behavior,
C A Pedersen, and J D Caldwell, and M McGuire, and D L Evans
Corticotropin-releasing factor inhibits maternal aggression in mice.
August 2004, Behavioral neuroscience,
C A Pedersen, and J D Caldwell, and M McGuire, and D L Evans
Circulating maternal corticotropin-releasing hormone and gonadotropin-releasing hormone in normal and abnormal pregnancies.
October 1996, American journal of obstetrics and gynecology,
C A Pedersen, and J D Caldwell, and M McGuire, and D L Evans
Maternal corticotropin-releasing hormone, fetal growth, and preterm birth.
October 2004, American journal of obstetrics and gynecology,
C A Pedersen, and J D Caldwell, and M McGuire, and D L Evans
[Corticotropin-releasing hormone].
January 1984, Medicina,
C A Pedersen, and J D Caldwell, and M McGuire, and D L Evans
Corticotropin-releasing hormone.
July 1988, The New England journal of medicine,
C A Pedersen, and J D Caldwell, and M McGuire, and D L Evans
Maternal corticotropin-releasing hormone and habituation in the human fetus.
April 1999, Developmental psychobiology,
C A Pedersen, and J D Caldwell, and M McGuire, and D L Evans
Corticotropin-releasing hormone promotes blastocyst implantation and early maternal tolerance.
November 2001, Nature immunology,
C A Pedersen, and J D Caldwell, and M McGuire, and D L Evans
Maternal corticotropin-releasing hormone levels during pregnancy and offspring adiposity.
September 2006, Obesity (Silver Spring, Md.),
C A Pedersen, and J D Caldwell, and M McGuire, and D L Evans
Corticotropin-Releasing Hormone (CRH) Programs the Fetal and Maternal Brain.
May 2009, Future neurology,
Copied contents to your clipboard!