-transparent.png){kind=logo}
Thyroid-stimulating antibodies (TSAb) were found to inhibit the binding of labelled thyrotrophin (TSH) to thyroid membranes in a dose-dependent manner and this effect was localized in the Fab part of the TSAb molecule. Analysis of the binding data suggested that TSAb and TSH bound to the same receptor site. Production of cyclic AMP by the thyroid membranes was stimulated by TSAb and TSAb-Fab with a similar time course to that observed with TSH. Kinetic studies indicated that the binding of TSAb to the thyroid membranes was not rate-limiting in the process of stimulation of cyclic AMP production.
Related Publications
B R Smith, and
G A Pyle, and
V B Petersen, and
R Hall
November 1977,
FEBS letters,
B R Smith, and
G A Pyle, and
V B Petersen, and
R Hall
July 1981,
Acta endocrinologica,
B R Smith, and
G A Pyle, and
V B Petersen, and
R Hall
August 1990,
Biochemical Society transactions,
B R Smith, and
G A Pyle, and
V B Petersen, and
R Hall
January 1992,
Lancet (London, England),
B R Smith, and
G A Pyle, and
V B Petersen, and
R Hall
November 1974,
The Journal of endocrinology,
B R Smith, and
G A Pyle, and
V B Petersen, and
R Hall
June 1974,
The Journal of endocrinology,
B R Smith, and
G A Pyle, and
V B Petersen, and
R Hall
March 1983,
The Journal of endocrinology,
B R Smith, and
G A Pyle, and
V B Petersen, and
R Hall
May 1991,
Biochemical and biophysical research communications,
B R Smith, and
G A Pyle, and
V B Petersen, and
R Hall
June 2009,
Endocrinology and metabolism clinics of North America,
B R Smith, and
G A Pyle, and
V B Petersen, and
R Hall
January 1983,
Acta endocrinologica,
