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Variants in FAM13A are associated with chronic obstructive pulmonary disease. 2010
Michael H Cho, and
Nadia Boutaoui, and
Barbara J Klanderman, and
Jody S Sylvia, and
John P Ziniti, and
Craig P Hersh, and
Dawn L DeMeo, and
Gary M Hunninghake, and
Augusto A Litonjua, and
David Sparrow, and
Christoph Lange, and
Sungho Won, and
James R Murphy, and
Terri H Beaty, and
Elizabeth A Regan, and
Barry J Make, and
John E Hokanson, and
James D Crapo, and
Xiangyang Kong, and
Wayne H Anderson, and
Ruth Tal-Singer, and
David A Lomas, and
Per Bakke, and
Amund Gulsvik, and
Sreekumar G Pillai, and
Edwin K Silverman
Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
We performed a genome-wide association study for chronic obstructive pulmonary disease (COPD) in three population cohorts, including 2,940 cases and 1,380 controls who were current or former smokers with normal lung function. We identified a new susceptibility locus at 4q22.1 in FAM13A and replicated this association in one case-control group (n = 1,006) and two family-based cohorts (n = 3,808) (rs7671167, combined P = 1.2 x 10(-11), combined odds ratio in case-control studies 0.76, 95% confidence interval 0.69-0.83).
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Craig P Hersh, and
Dawn L DeMeo, and
Gary M Hunninghake, and
Augusto A Litonjua, and
David Sparrow, and
Christoph Lange, and
Sungho Won, and
James R Murphy, and
Terri H Beaty, and
Elizabeth A Regan, and
Barry J Make, and
John E Hokanson, and
James D Crapo, and
Xiangyang Kong, and
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Ruth Tal-Singer, and
David A Lomas, and
Per Bakke, and
Amund Gulsvik, and
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Edwin K Silverman
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John E Hokanson, and
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Gary M Hunninghake, and
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David Sparrow, and
Christoph Lange, and
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Terri H Beaty, and
Elizabeth A Regan, and
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Gary M Hunninghake, and
Augusto A Litonjua, and
David Sparrow, and
Christoph Lange, and
Sungho Won, and
James R Murphy, and
Terri H Beaty, and
Elizabeth A Regan, and
Barry J Make, and
John E Hokanson, and
James D Crapo, and
Xiangyang Kong, and
Wayne H Anderson, and
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David A Lomas, and
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