Effects of chronic fluoxetine treatment on behavioral and neuroendocrine responses to meta-chlorophenylpiperazine in obsessive-compulsive disorder. 1991

E Hollander, and C DeCaria, and R Gully, and A Nitescu, and R F Suckow, and J M Gorman, and D F Klein, and M R Liebowitz
College of Physicians and Surgeons of Columbia University, New York, NY.

To investigate the effect of fluoxetine on serotonergic sensitivity in obsessive-compulsive disorder (OCD), the partial serotonin agonist metachlorophenylpiperazine (mCPP) was compared to placebo under double-blind conditions in six patients with OCD before and during treatment with fluoxetine. Readministration of oral mCPP (0.5 mg/kg) after at least 12 weeks of fluoxetine treatment did not increase obsessive-compulsive (OC) symptoms, in contrast to exacerbation of OC symptoms produced by mCPP before treatment. Chronic fluoxetine treatment resulted in a significant increase in prolactin and cortisol response to mCPP. This may be accounted for, however, by substantially increased plasma mCPP levels during fluoxetine treatment. Chronic fluoxetine treatment diminished the behavioral sensitivity to mCPP and did not diminish, but may have partially normalized, the neuroendocrine response to mCPP in patients with OCD. These adaptive homeostatic effects may reflect fluoxetine's antiobsessional mechanism.

UI MeSH Term Description Entries
D008297 Male Males
D009771 Obsessive-Compulsive Disorder An anxiety disorder characterized by recurrent, persistent obsessions or compulsions. Obsessions are the intrusive ideas, thoughts, or images that are experienced as senseless or repugnant. Compulsions are repetitive and seemingly purposeful behavior which the individual generally recognizes as senseless and from which the individual does not derive pleasure although it may provide a release from tension. Anankastic Personality,Neurosis, Obsessive-Compulsive,Anankastic Personalities,Disorder, Obsessive-Compulsive,Disorders, Obsessive-Compulsive,Neuroses, Obsessive-Compulsive,Neurosis, Obsessive Compulsive,Obsessive Compulsive Disorder,Obsessive-Compulsive Disorders,Obsessive-Compulsive Neuroses,Obsessive-Compulsive Neurosis,Personalities, Anankastic,Personality, Anankastic
D010879 Piperazines Compounds that are derived from PIPERAZINE.
D011569 Psychiatric Status Rating Scales Standardized procedures utilizing rating scales or interview schedules carried out by health personnel for evaluating the degree of mental illness. Factor Construct Rating Scales (FCRS),Katz Adjustment Scales,Lorr's Inpatient Multidimensional Psychiatric Rating Scale,Wittenborn Scales,Edinburgh Postnatal Depression Scale,Mini International Neuropsychiatric Interview
D011985 Receptors, Serotonin Cell-surface proteins that bind SEROTONIN and trigger intracellular changes which influence the behavior of cells. Several types of serotonin receptors have been recognized which differ in their pharmacology, molecular biology, and mode of action. 5-HT Receptor,5-HT Receptors,5-Hydroxytryptamine Receptor,5-Hydroxytryptamine Receptors,Receptors, Tryptamine,Serotonin Receptor,Serotonin Receptors,Tryptamine Receptor,Tryptamine Receptors,Receptors, 5-HT,Receptors, 5-Hydroxytryptamine,5 HT Receptor,5 HT Receptors,5 Hydroxytryptamine Receptor,5 Hydroxytryptamine Receptors,Receptor, 5-HT,Receptor, 5-Hydroxytryptamine,Receptor, Serotonin,Receptor, Tryptamine,Receptors, 5 HT,Receptors, 5 Hydroxytryptamine
D001921 Brain The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM. Encephalon
D005260 Female Females
D005473 Fluoxetine The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants. Fluoxetin,Fluoxetine Hydrochloride,Lilly-110140,N-Methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine,Prozac,Sarafem,Lilly 110140,Lilly110140
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006854 Hydrocortisone The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions. Cortef,Cortisol,Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-,11-Epicortisol,Cortifair,Cortril,Epicortisol,Hydrocortisone, (11 alpha)-Isomer,Hydrocortisone, (9 beta,10 alpha,11 alpha)-Isomer,11 Epicortisol

Related Publications

E Hollander, and C DeCaria, and R Gully, and A Nitescu, and R F Suckow, and J M Gorman, and D F Klein, and M R Liebowitz
February 2001, Psychoneuroendocrinology,
E Hollander, and C DeCaria, and R Gully, and A Nitescu, and R F Suckow, and J M Gorman, and D F Klein, and M R Liebowitz
March 1991, Biological psychiatry,
E Hollander, and C DeCaria, and R Gully, and A Nitescu, and R F Suckow, and J M Gorman, and D F Klein, and M R Liebowitz
September 1998, Biological psychiatry,
E Hollander, and C DeCaria, and R Gully, and A Nitescu, and R F Suckow, and J M Gorman, and D F Klein, and M R Liebowitz
November 1989, The Journal of clinical psychiatry,
E Hollander, and C DeCaria, and R Gully, and A Nitescu, and R F Suckow, and J M Gorman, and D F Klein, and M R Liebowitz
December 1991, Canadian journal of psychiatry. Revue canadienne de psychiatrie,
E Hollander, and C DeCaria, and R Gully, and A Nitescu, and R F Suckow, and J M Gorman, and D F Klein, and M R Liebowitz
August 1985, Journal of clinical psychopharmacology,
E Hollander, and C DeCaria, and R Gully, and A Nitescu, and R F Suckow, and J M Gorman, and D F Klein, and M R Liebowitz
January 1991, Journal of psychopharmacology (Oxford, England),
E Hollander, and C DeCaria, and R Gully, and A Nitescu, and R F Suckow, and J M Gorman, and D F Klein, and M R Liebowitz
December 2022, Neuroscience,
E Hollander, and C DeCaria, and R Gully, and A Nitescu, and R F Suckow, and J M Gorman, and D F Klein, and M R Liebowitz
January 1985, Progress in neuro-psychopharmacology & biological psychiatry,
E Hollander, and C DeCaria, and R Gully, and A Nitescu, and R F Suckow, and J M Gorman, and D F Klein, and M R Liebowitz
September 1991, Psychiatry research,
Copied contents to your clipboard!