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Infections of deep soft tissues with the dimorphic fungus Sporothrix schenckii are uncommon in humans, and therapy has often required toxic drugs. We report our experience in treating 11 patients who had deep-seated sporotrichosis with ketoconazole, a well-tolerated, orally absorbed antifungal agent. Eight infections involved one or more joints, and three involved thoracic, cervical, and widespread cutaneous sites, respectively. For eight patients all evidence of infection resolved during therapy. Sustained remissions (6 months to 5 years) were noted for six patients after the discontinuation of all therapy and for an additional patient 4 years after the initiation of ketoconazole treatment. Durable responses were associated with prolonged treatment with 400-800 mg of ketoconazole daily. Our favorable experience suggests that oral therapy with ketoconazole may benefit other patients with systemic sporotrichosis.
D L Calhoun, and
H Waskin, and
M P White, and
J R Bonner, and
J H Mulholland, and
L W Rumans, and
D A Stevens, and
J N Galgiani
April 1982,
Revista do Hospital das Clinicas,
D L Calhoun, and
H Waskin, and
M P White, and
J R Bonner, and
J H Mulholland, and
L W Rumans, and
D A Stevens, and
J N Galgiani
January 1987,
Reviews of infectious diseases,
D L Calhoun, and
H Waskin, and
M P White, and
J R Bonner, and
J H Mulholland, and
L W Rumans, and
D A Stevens, and
J N Galgiani
September 1992,
Journal of the American Academy of Dermatology,
D L Calhoun, and
H Waskin, and
M P White, and
J R Bonner, and
J H Mulholland, and
L W Rumans, and
D A Stevens, and
J N Galgiani
January 1993,
Scandinavian journal of infectious diseases,
D L Calhoun, and
H Waskin, and
M P White, and
J R Bonner, and
J H Mulholland, and
L W Rumans, and
D A Stevens, and
J N Galgiani
May 1986,
Mykosen,
D L Calhoun, and
H Waskin, and
M P White, and
J R Bonner, and
J H Mulholland, and
L W Rumans, and
D A Stevens, and
J N Galgiani
May 1984,
Cutis,
D L Calhoun, and
H Waskin, and
M P White, and
J R Bonner, and
J H Mulholland, and
L W Rumans, and
D A Stevens, and
J N Galgiani
October 1987,
Minerva ginecologica,
D L Calhoun, and
H Waskin, and
M P White, and
J R Bonner, and
J H Mulholland, and
L W Rumans, and
D A Stevens, and
J N Galgiani
March 1984,
Journal of the Canadian Association of Radiologists,
D L Calhoun, and
H Waskin, and
M P White, and
J R Bonner, and
J H Mulholland, and
L W Rumans, and
D A Stevens, and
J N Galgiani
July 1970,
Annals of internal medicine,
D L Calhoun, and
H Waskin, and
M P White, and
J R Bonner, and
J H Mulholland, and
L W Rumans, and
D A Stevens, and
J N Galgiani
September 1985,
Experimental hematology,
