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OBJECTIVE To compare general and eating disorder-specific psychopathology in patients with acute anorexia nervosa (acAN), weight-recovered patients (recAN) and healthy control women (HCW). METHODS One hundred anorexia nervosa patients (66 acAN and 34 recAN) and 88 HCW were included in our study. Psychopathology was assessed by self-report questionnaires [Symptom Check List 90 Revised (SCL-90-R), Eating Disorder Inventory-2 (EDI- 2)] as well as by interview [Structured Interview of Anorexia Nervosa and Bulimic Syndromes (SIAB-EX)] and compared using multivariate analysis of variance. Plasma leptin levels were determined using enzyme linked immunosorbent assay. RESULTS Mean comparisons indicated highly significant differences between acAN and recAN subjects on all psychopatholgy variables, except for perfectionism. RecAN subjects did not differ from HCW. Partial weight recovery was associated with decreasing levels of psychopathology. Correlational analyses suggested strong negative associations between leptin levels and psychopathology. CONCLUSIONS Prolonged malnutrition, as indicated by suppressed plasma leptin levels, is strongly related to eating disorder-specific as well as general psychopathological symptoms. Weight recovery is associated with the absence of psychopathology. These data emphasize the interaction between somatic and psychological variables.
N Schneider, and
H Salbach-Andrae, and
J V Merle, and
J Hein, and
E Pfeiffer, and
U Lehmkuhl, and
S Ehrlich
November 2008,
Pharmacopsychiatry,
N Schneider, and
H Salbach-Andrae, and
J V Merle, and
J Hein, and
E Pfeiffer, and
U Lehmkuhl, and
S Ehrlich
July 2008,
Psychoneuroendocrinology,
N Schneider, and
H Salbach-Andrae, and
J V Merle, and
J Hein, and
E Pfeiffer, and
U Lehmkuhl, and
S Ehrlich
October 2014,
Progress in neuro-psychopharmacology & biological psychiatry,
N Schneider, and
H Salbach-Andrae, and
J V Merle, and
J Hein, and
E Pfeiffer, and
U Lehmkuhl, and
S Ehrlich
November 2007,
The International journal of eating disorders,
N Schneider, and
H Salbach-Andrae, and
J V Merle, and
J Hein, and
E Pfeiffer, and
U Lehmkuhl, and
S Ehrlich
September 2010,
European archives of psychiatry and clinical neuroscience,
N Schneider, and
H Salbach-Andrae, and
J V Merle, and
J Hein, and
E Pfeiffer, and
U Lehmkuhl, and
S Ehrlich
November 2021,
Psychophysiology,
N Schneider, and
H Salbach-Andrae, and
J V Merle, and
J Hein, and
E Pfeiffer, and
U Lehmkuhl, and
S Ehrlich
April 1995,
The International journal of eating disorders,
N Schneider, and
H Salbach-Andrae, and
J V Merle, and
J Hein, and
E Pfeiffer, and
U Lehmkuhl, and
S Ehrlich
December 2020,
Journal of psychiatric research,
N Schneider, and
H Salbach-Andrae, and
J V Merle, and
J Hein, and
E Pfeiffer, and
U Lehmkuhl, and
S Ehrlich
August 2010,
Neuropsychobiology,
N Schneider, and
H Salbach-Andrae, and
J V Merle, and
J Hein, and
E Pfeiffer, and
U Lehmkuhl, and
S Ehrlich
April 2021,
Progress in neuro-psychopharmacology & biological psychiatry,
