Biomaterial Database

[MTHFR gene polymorphism and male infertility]. 2010

Shan-Shan Li, and Jian Li

Department of Reproduction Regulation, Beijing Obstetrics and Gynecology Hospital Affiliated to Capital Medical University, Beijing 100026, China. lishanshan309@yahoo.com.cn

Unexplained male infertility is mostly due to sperm-related gene mutations in the spermatogenic process. Methylenetetrahydrofolate reductase (MTHFR) plays an important role in the process of DNA, RNA and protein metabolism, and is closely related with spermatogenesis. Researchers have found more than 20 single nucleotide polymorphisms (SNP) of the MTHFR gene. The polymorphisms of MTHFRC677T and A1298C may have a close relationship with male infertility. But the correlation between MTHFRG1793 and male infertility needs to be further studied.

UI	MeSH Term	Description	Entries
D007248	Infertility, Male	The inability of the male to effect FERTILIZATION of an OVUM after a specified period of unprotected intercourse. Male sterility is permanent infertility.	Sterility, Male,Sub-Fertility, Male,Subfertility, Male,Male Infertility,Male Sterility,Male Sub-Fertility,Male Subfertility,Sub Fertility, Male
D008297	Male		Males
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D042965	Methylenetetrahydrofolate Reductase (NADPH2)	A flavoprotein amine oxidoreductase that catalyzes the reversible conversion of 5-methyltetrahydrofolate to 5,10-methylenetetrahydrofolate. This enzyme was formerly classified as EC 1.1.1.171.	Methylene-THF Reductase (NADPH),5,10-Methylenetetrahydrofolate Reductase (NADPH),Methylene Tetrahydrofolate Reductase,Methylenetetrahydrofolate Reductase,Methylenetetrahydrofolate Reductase (NADPH),Tetrahydrofolate Reductase, Methylene
D020641	Polymorphism, Single Nucleotide	A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.	SNPs,Single Nucleotide Polymorphism,Nucleotide Polymorphism, Single,Nucleotide Polymorphisms, Single,Polymorphisms, Single Nucleotide,Single Nucleotide Polymorphisms