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OBJECTIVE The authors compared the effects of acetorphan, an enkephalinase inhibitor, with those of clonidine for the treatment of the opioid withdrawal syndrome. Nineteen patients addicted to heroin or synthetic opiates who were undergoing drug withdrawal and displayed a withdrawal syndrome according to DSM-III criteria were studied for 5 days in a hospital setting. In a double-blind trial, 10 subjects were given acetorphan intravenously and nine were given clonidine; objective signs and subjective symptoms of withdrawal were recorded. RESULTS On several objective signs, the effect of acetorphan was more marked than that of clonidine, whereas the two drugs exhibited similar efficacy with respect to the subjective components of withdrawal. No side effect was noted in the subjects who received acetorphan. CONCLUSIONS Enkephalinase inhibition may constitute a novel and safe therapeutic approach to the opioid withdrawal syndrome.
F Hartmann, and
M F Poirier, and
M C Bourdel, and
H Loo, and
J M Lecomte, and
J C Schwartz
December 1978,
JAMA,
F Hartmann, and
M F Poirier, and
M C Bourdel, and
H Loo, and
J M Lecomte, and
J C Schwartz
September 1978,
Lancet (London, England),
F Hartmann, and
M F Poirier, and
M C Bourdel, and
H Loo, and
J M Lecomte, and
J C Schwartz
October 1983,
Journal of psychosocial nursing and mental health services,
F Hartmann, and
M F Poirier, and
M C Bourdel, and
H Loo, and
J M Lecomte, and
J C Schwartz
June 1986,
American family physician,
F Hartmann, and
M F Poirier, and
M C Bourdel, and
H Loo, and
J M Lecomte, and
J C Schwartz
October 1981,
Indian journal of psychiatry,
F Hartmann, and
M F Poirier, and
M C Bourdel, and
H Loo, and
J M Lecomte, and
J C Schwartz
November 1979,
The Medical letter on drugs and therapeutics,
F Hartmann, and
M F Poirier, and
M C Bourdel, and
H Loo, and
J M Lecomte, and
J C Schwartz
August 1981,
Lancet (London, England),
F Hartmann, and
M F Poirier, and
M C Bourdel, and
H Loo, and
J M Lecomte, and
J C Schwartz
September 1980,
Lancet (London, England),
F Hartmann, and
M F Poirier, and
M C Bourdel, and
H Loo, and
J M Lecomte, and
J C Schwartz
January 1993,
Journal of substance abuse treatment,
F Hartmann, and
M F Poirier, and
M C Bourdel, and
H Loo, and
J M Lecomte, and
J C Schwartz
January 1981,
Current psychiatric therapies,
