BIOMAT Database Logo BIOMAT Database Logo

A variant in the fat mass and obesity-associated gene (FTO) and variants near the melanocortin-4 receptor gene (MC4R) do not influence dietary intake. 2010

Ann L Hasselbalch, and Lars Angquist, and Lene Christiansen, and Berit L Heitmann, and Kirsten O Kyvik, and Thorkild I A Sørensen
Institute of Preventive Medicine, Copenhagen Capital Region, Copenhagen University Hospitals, Centre for Health and Society, Copenhagen, Denmark. awj@ipm.regionh.dk

We investigated the role of the fat mass and obesity associated gene (FTO) and variants near the melanocortin-4 receptor gene (MC4R) in modulating habitual intake of total energy and macronutrients, glycemic index, glycemic load, dietary energy density, and energy from 20 food groups in adults. In a population-based sample of 756 healthy adult twin pairs, we studied associations between FTO rs9939609, near-MC4R rs12970134, rs17700633, and rs17782313 single nucleotide polymorphisms (SNP) and habitual dietary intake. Habitual dietary intake was assessed by a 247-question FFQ. Nontransformed variables and variables transformed by natural logarithm were analyzed by linear regression and dichotomized variables were analyzed by logistic regression. FTO SNP rs9939609 was not associated with habitual dietary intake. For the near-MC4R SNP rs12970134 and rs17700633, we found significant positive associations with intake of energy from whole grains (P >or= 0.04). These associations did not remain significant after controlling for multiple testing. The outcome of this study indicates that polymorphisms in the FTO gene and near the MC4R gene do not have a role in regulating food intake and preference for specific food items.

UI MeSH Term Description Entries
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011506 Proteins Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein. Gene Products, Protein,Gene Proteins,Protein,Protein Gene Products,Proteins, Gene
D004435 Eating The consumption of edible substances. Dietary Intake,Feed Intake,Food Intake,Macronutrient Intake,Micronutrient Intake,Nutrient Intake,Nutritional Intake,Ingestion,Dietary Intakes,Feed Intakes,Intake, Dietary,Intake, Feed,Intake, Food,Intake, Macronutrient,Intake, Micronutrient,Intake, Nutrient,Intake, Nutritional,Macronutrient Intakes,Micronutrient Intakes,Nutrient Intakes,Nutritional Intakes
D005838 Genotype The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS. Genogroup,Genogroups,Genotypes
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000071516 Alpha-Ketoglutarate-Dependent Dioxygenase FTO A dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. It has highest activity towards single-stranded RNA containing 3-methyluracil, followed by SINGLE-STRANDED DNA containing 3-methylthymine and specifically demethylates N(6)-methyladenosine (m6A) RNA, the most common internal modification of MESSENGER RNA (mRNA) in higher EUKARYOTES. It contributes to the regulation of the global metabolic rate, energy HOMEOSTASIS, as well as body fat accumulation by regulating the differentiation of ADIPOCYTES into BROWN FAT CELLS or WHITE FAT CELLS. AlkB Homolog 9 Protein,Alpha-Ketoglutarate-Dependent Dioxygenase,Fat Mass and Obesity Associated (FTO) Protein,Fat Mass and Obesity Associated Protein,Alpha Ketoglutarate Dependent Dioxygenase,Alpha Ketoglutarate Dependent Dioxygenase FTO,Dioxygenase, Alpha-Ketoglutarate-Dependent,FTO, Alpha-Ketoglutarate-Dependent Dioxygenase
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D014644 Genetic Variation Genotypic differences observed among individuals in a population. Genetic Diversity,Variation, Genetic,Diversity, Genetic,Diversities, Genetic,Genetic Diversities,Genetic Variations,Variations, Genetic

Related Publications

Ann L Hasselbalch, and Lars Angquist, and Lene Christiansen, and Berit L Heitmann, and Kirsten O Kyvik, and Thorkild I A Sørensen
Associations between obesity candidate gene polymorphisms (fat mass and obesity-associated (FTO), melanocortin-4 receptor (MC4R), leptin (LEP) and leptin receptor (LEPR)) and dietary intake in pregnant women.
August 2018, The British journal of nutrition,
Ann L Hasselbalch, and Lars Angquist, and Lene Christiansen, and Berit L Heitmann, and Kirsten O Kyvik, and Thorkild I A Sørensen
Fat mass obesity-associated (FTO) (rs9939609) and melanocortin 4 receptor (MC4R) (rs17782313) SNP are positively associated with obesity and blood pressure in Mexican school-aged children.
November 2016, The British journal of nutrition,
Ann L Hasselbalch, and Lars Angquist, and Lene Christiansen, and Berit L Heitmann, and Kirsten O Kyvik, and Thorkild I A Sørensen
Fat mass and obesity-associated (fto) gene and alcohol intake.
June 2012, Addiction (Abingdon, England),
Ann L Hasselbalch, and Lars Angquist, and Lene Christiansen, and Berit L Heitmann, and Kirsten O Kyvik, and Thorkild I A Sørensen
A novel melanocortin 4 receptor (MC4R) gene mutation associated with morbid obesity.
July 2001, The Journal of clinical endocrinology and metabolism,
Ann L Hasselbalch, and Lars Angquist, and Lene Christiansen, and Berit L Heitmann, and Kirsten O Kyvik, and Thorkild I A Sørensen
Association of the fat mass and obesity-associated (FTO) gene variant (rs9939609) with dietary intake in the Finnish Diabetes Prevention Study.
November 2012, The British journal of nutrition,
Ann L Hasselbalch, and Lars Angquist, and Lene Christiansen, and Berit L Heitmann, and Kirsten O Kyvik, and Thorkild I A Sørensen
Variants in the fat mass- and obesity-associated (FTO) gene are not associated with obesity in a Chinese Han population.
January 2008, Diabetes,
Ann L Hasselbalch, and Lars Angquist, and Lene Christiansen, and Berit L Heitmann, and Kirsten O Kyvik, and Thorkild I A Sørensen
Selected variants of the melanocortin 4 receptor gene (MC4R) do not confer susceptibility to female pattern hair loss.
April 2013, Archives of dermatological research,
Ann L Hasselbalch, and Lars Angquist, and Lene Christiansen, and Berit L Heitmann, and Kirsten O Kyvik, and Thorkild I A Sørensen
A missense variant of the porcine melanocortin-4 receptor (MC4R) gene is associated with fatness, growth, and feed intake traits.
February 2000, Mammalian genome : official journal of the International Mammalian Genome Society,
Ann L Hasselbalch, and Lars Angquist, and Lene Christiansen, and Berit L Heitmann, and Kirsten O Kyvik, and Thorkild I A Sørensen
Common variants near MC4R are associated with fat mass, weight and risk of obesity.
June 2008, Nature genetics,
Ann L Hasselbalch, and Lars Angquist, and Lene Christiansen, and Berit L Heitmann, and Kirsten O Kyvik, and Thorkild I A Sørensen
Familial early-onset obesity in Turkish children: variants and polymorphisms in the melanocortin-4 receptor (MC4R) gene.
May 2022, Journal of pediatric endocrinology & metabolism : JPEM,
Copied contents to your clipboard!