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There is considerable dissatisfaction with present second messenger hypotheses involving cyclic nucleotides and calcium. The recent findings that methyl xanthines and adenosine are prostaglandin antagonists casts doubt on much of the evidence in favour of the cyclic AMP hypothesis. There is evidence that allosteric sites may modify the binding of calcium and cyclic nucleotides to key cellular regulators and that a range of substances including steroids, adenosine and prostaglandins may occupy those sites. This concept introduces much needed flexibility into the second messenger concept, allows many experiments to be reinterpreted and has major implications throughout the biomedical sciences.
D F Horrobin, and
M S Manku, and
R A Karmali, and
A I Ally, and
M Karmazyn, and
R O Morgan
January 1977,
Society of General Physiologists series,
D F Horrobin, and
M S Manku, and
R A Karmali, and
A I Ally, and
M Karmazyn, and
R O Morgan
January 1975,
Journal of cyclic nucleotide research,
D F Horrobin, and
M S Manku, and
R A Karmali, and
A I Ally, and
M Karmazyn, and
R O Morgan
July 1977,
Agents and actions,
D F Horrobin, and
M S Manku, and
R A Karmali, and
A I Ally, and
M Karmazyn, and
R O Morgan
August 2005,
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D F Horrobin, and
M S Manku, and
R A Karmali, and
A I Ally, and
M Karmazyn, and
R O Morgan
January 1991,
Life sciences,
D F Horrobin, and
M S Manku, and
R A Karmali, and
A I Ally, and
M Karmazyn, and
R O Morgan
April 1985,
General physiology and biophysics,
D F Horrobin, and
M S Manku, and
R A Karmali, and
A I Ally, and
M Karmazyn, and
R O Morgan
October 2007,
Physiology (Bethesda, Md.),
D F Horrobin, and
M S Manku, and
R A Karmali, and
A I Ally, and
M Karmazyn, and
R O Morgan
January 1970,
Advances in biochemical psychopharmacology,
D F Horrobin, and
M S Manku, and
R A Karmali, and
A I Ally, and
M Karmazyn, and
R O Morgan
March 1991,
Zeitschrift fur Gastroenterologie. Verhandlungsband,
D F Horrobin, and
M S Manku, and
R A Karmali, and
A I Ally, and
M Karmazyn, and
R O Morgan
January 1981,
Prostaglandins,
