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OBJECTIVE Cancer patients may have extracellular fluid volume (ECV) abnormalities that potentially invalidate glomerular filtration rate (GFR) measured using the slope-intercept technique. The aim was to test this concern by measuring ECV in cancer patients in comparison with noncancer patients and healthy kidney donors. METHODS GFR was measured with Cr-EDTA and the slope-intercept technique in patients from two hospitals, the first using three samples (540 adults, including 382 with cancer, and 124 children, including 40 with cancer) and the second using four samples (256 adults, including 132 with cancer and 75 donors), scaled to body surface area (BSA) of 1.73 m and corrected using Brochner-Mortensen's equations (GFR/BSA). GFR/ECV was measured from the exponential rate constant with an appropriate one-compartment correction. ECV/BSA was calculated as the quotient, GFR/BSA:GFR/ECV. ECV was also expressed in adults in relation to lean body mass and in children as a fraction of ECV estimated from height and weight (eECV). RESULTS In men from both centres, neither ECV/BSA nor ECV/lean body mass showed an increase in cancer patients. In women from both centres, however, they were both significantly higher in cancer patients than in noncancer patients and, in centre 2, than in donors. In children from centre 1, ECV/BSA, but not ECV/eECV, was significantly higher in cancer patients. CONCLUSIONS ECV is expanded in female cancer patients but not male cancer patients. ECV may be expanded in children with cancer but the recorded difference in ECV/BSA is probably related to differences in patient size and a nonproportionate relationship between ECV and BSA.
Hayley L R Snelling, and
Myron B Ciapryna, and
Philippe F Bowles, and
Daphne M Glass, and
Maria T Burniston, and
A Michael Peters
March 1953,
Surgery, gynecology & obstetrics,
Hayley L R Snelling, and
Myron B Ciapryna, and
Philippe F Bowles, and
Daphne M Glass, and
Maria T Burniston, and
A Michael Peters
January 1953,
Surgical forum,
Hayley L R Snelling, and
Myron B Ciapryna, and
Philippe F Bowles, and
Daphne M Glass, and
Maria T Burniston, and
A Michael Peters
January 1954,
Archivio di chirurgia del torace,
Hayley L R Snelling, and
Myron B Ciapryna, and
Philippe F Bowles, and
Daphne M Glass, and
Maria T Burniston, and
A Michael Peters
January 1957,
Nordisk medicin,
Hayley L R Snelling, and
Myron B Ciapryna, and
Philippe F Bowles, and
Daphne M Glass, and
Maria T Burniston, and
A Michael Peters
August 2002,
Clinical autonomic research : official journal of the Clinical Autonomic Research Society,
Hayley L R Snelling, and
Myron B Ciapryna, and
Philippe F Bowles, and
Daphne M Glass, and
Maria T Burniston, and
A Michael Peters
October 1983,
Archives of internal medicine,
Hayley L R Snelling, and
Myron B Ciapryna, and
Philippe F Bowles, and
Daphne M Glass, and
Maria T Burniston, and
A Michael Peters
December 1956,
Canadian Medical Association journal,
Hayley L R Snelling, and
Myron B Ciapryna, and
Philippe F Bowles, and
Daphne M Glass, and
Maria T Burniston, and
A Michael Peters
February 1955,
The Journal of the International College of Surgeons,
Hayley L R Snelling, and
Myron B Ciapryna, and
Philippe F Bowles, and
Daphne M Glass, and
Maria T Burniston, and
A Michael Peters
November 1976,
Wiener medizinische Wochenschrift (1946),
Hayley L R Snelling, and
Myron B Ciapryna, and
Philippe F Bowles, and
Daphne M Glass, and
Maria T Burniston, and
A Michael Peters
October 1969,
The Journal of the American Association of Nurse Anesthetists,
