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The authors investigated, in vivo, the effects of four vasodilators on venous tone in dogs. Baseline venous tone was determined from the pressure: diameter relationships in the inferior vena cava (VSIVC) and femoral vein (VSFV) as measured during several seconds of occlusion of the proximal inferior vena cava. All of the slopes were nearly linear. All vasodilators were administered in dosages sufficient to lower blood pressure by approximately 20%; these dosages also decreased systemic vascular resistance by 15% to 30%. Isosorbide dinitrate reduced VSIVC from 7.17 +/- 0.81 to 5.81 +/- 0.73 mmHg/mm and VSIVC from 59.4 +/- 13.5 to 37.2 +/- 6.6 mmHg/mm. Neither nifedipine nor nisoldipine altered VSIVC or VSFV. However, prazosin decreased VSIVC from 13.2 +/- 3.3 to 10.7 +/- 2.7 mmHg/mm and VSFV from 43.5 +/- 11.3 to 29.9 +/- 8.8 mmHg/mm. These results suggest that isosorbide dinitrate and prazosin decrease venous tone in vivo, whereas nifedipine and nisoldipine do not.
S Ogawa, and
G Narita, and
H Nomura, and
F Yasuma, and
K Miyaguchi, and
H Hayashi, and
I Sotobata
May 1982,
The Journal of thoracic and cardiovascular surgery,
S Ogawa, and
G Narita, and
H Nomura, and
F Yasuma, and
K Miyaguchi, and
H Hayashi, and
I Sotobata
December 1960,
The Journal of laboratory and clinical medicine,
S Ogawa, and
G Narita, and
H Nomura, and
F Yasuma, and
K Miyaguchi, and
H Hayashi, and
I Sotobata
January 1979,
Investigative radiology,
S Ogawa, and
G Narita, and
H Nomura, and
F Yasuma, and
K Miyaguchi, and
H Hayashi, and
I Sotobata
March 2014,
The International journal of angiology : official publication of the International College of Angiology, Inc,
S Ogawa, and
G Narita, and
H Nomura, and
F Yasuma, and
K Miyaguchi, and
H Hayashi, and
I Sotobata
March 1989,
European journal of pharmacology,
S Ogawa, and
G Narita, and
H Nomura, and
F Yasuma, and
K Miyaguchi, and
H Hayashi, and
I Sotobata
January 1977,
Japanese heart journal,
S Ogawa, and
G Narita, and
H Nomura, and
F Yasuma, and
K Miyaguchi, and
H Hayashi, and
I Sotobata
July 1986,
Japanese journal of pharmacology,
S Ogawa, and
G Narita, and
H Nomura, and
F Yasuma, and
K Miyaguchi, and
H Hayashi, and
I Sotobata
January 1959,
Minerva medica,
S Ogawa, and
G Narita, and
H Nomura, and
F Yasuma, and
K Miyaguchi, and
H Hayashi, and
I Sotobata
January 1981,
Journal of cardiovascular pharmacology,
S Ogawa, and
G Narita, and
H Nomura, and
F Yasuma, and
K Miyaguchi, and
H Hayashi, and
I Sotobata
January 1992,
Archives internationales de pharmacodynamie et de therapie,
