Biomaterial Database

Colchicine effects on the mouse liver. 1967

J Myren, and R Ceballos, and G C Luketic

Division of Gastroenterology, Department of Medicine and Pathology, University of Alabama Medical Center, Birmingham, Alabama, USA.

With histochemical methods an instantaneous and marked inhibitory effect of a single dose of colchicine on the activity of succinic-, lactic-, glucose-6-phosphate-, NADH- and NADPH-dehydrogenase in the mouse liver was observed. This effect was essentially the same as that previously described in the intestinal mucosa and not dependent on or a consequence of the inhibitory effect of colchicine on cell division. The enzymatic inhibitory effect of colchicine was qualitatively similar regardless of the dose of the drug given, although a single large dose (1.5 mg/kg body weight) produced alterations and depression of dehydrogenase activity more marked and not so rapidly repaired as those appearing after a small dose of colchicine (0.24 mg/kg body weight). Following repeated doses of colchicine the degree of histochemically demonstrable depression of dehydrogenase activity was not obviously different from that found after a single dose. After large repeated doses morphological alterations and prolonged depression of dehydrogenase activity of liver cells were found and many of the animals died. After repeated administration of the small dose (0.24 mg/kg body weight) no morphological alterations were found and the activity of dehydrogenases was normalized, although the injection of colchicine was continued.

UI	MeSH Term	Description	Entries
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D008297	Male		Males
D010088	Oxidoreductases	The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)	Dehydrogenases,Oxidases,Oxidoreductase,Reductases,Dehydrogenase,Oxidase,Reductase
D003078	Colchicine	A major alkaloid from Colchicum autumnale L. and found also in other Colchicum species. Its primary therapeutic use is in the treatment of gout, but it has been used also in the therapy of familial Mediterranean fever (PERIODIC DISEASE).	Colchicine, (+-)-Isomer,Colchicine, (R)-Isomer
D004791	Enzyme Inhibitors	Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.	Enzyme Inhibitor,Inhibitor, Enzyme,Inhibitors, Enzyme
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D023421	Models, Animal	Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.	Experimental Animal Models,Laboratory Animal Models,Animal Model,Animal Model, Experimental,Animal Model, Laboratory,Animal Models,Animal Models, Experimental,Animal Models, Laboratory,Experimental Animal Model,Laboratory Animal Model,Model, Animal,Model, Experimental Animal,Model, Laboratory Animal,Models, Experimental Animal,Models, Laboratory Animal