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[Molecular basis of HIV-1 latency - part I: physiology of HIV-1 latency]. 2010
Christian Schwartz, and
Valentin Le Douce, and
Thomas Cherrier, and
Laetitia Redel, and
Céline Marban, and
Dominique Aunis, and
Olivier Rohr
Inserm Unité 575 Physiopathologie du système nerveux central, Institut de virologie, Strasbourg, France. schwartz.christian@iutlpa-strasbg.fr
The introduction of the highly active antiretroviral therapy (HAART) in 1996 has greatly extended survival and raised hopes for the eradication of HIV-1. Unfortunately, the optimism declined by revealing the existence of latent HIV-1 reservoirs in cells targeted by the virus. The long-lived HIV-1 reservoirs constitute a major obstacle to the eradication of HIV-1. Understanding the molecular mechanisms of virus latency is essential for efficient therapeutic intervention against the virus.
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