BIOMAT Database Logo BIOMAT Database Logo

Carbon paste and PVC electrodes for the flow injection potentiometric determination of dextromethorphan. 2010

Elmorsy Khaled, and H N A Hassan, and Gehad G Mohamed, and A A Seleim
Microanalysis Laboratory, National Research Centre, Dokki, Giza, Egypt. elmorsykhaled@yahoo.com

The construction and performance characteristics of dextromethorphan (DXM) carbon paste (CPEs) and polyvinyl chloride (PVC) electrodes are described. Different modes for electrode modification, including incorporation of ion pairs (IPs), ion pairing agent or soaking the plain electrode in IPs suspension, have been used. Matrices compositions were optimized referring to the effect of modifier and plasticizer. The fabricated electrodes work satisfactorily in the concentration range from 10(-5) to 10(-2) mol L(-1) with fast response time (1.6s) and long operational lifetime (2 months). The developed electrodes have been successfully applied for the potentiometric determination of DXM in pharmaceutical formulation under batch and flow injection analysis (FIA) conditions. Under FIA conditions, the proposed electrodes allow the analysis of 90 samples h(-1) and offer the advantage of simplicity, accuracy and automation feasibility. The solubility products of various DXM-IPs were determined conductometrically.

UI MeSH Term Description Entries
D009824 Ointments Semisolid preparations used topically for protective emollient effects or as a vehicle for local administration of medications. Ointment bases are various mixtures of fats, waxes, animal and plant oils and solid and liquid hydrocarbons. Ointment,Paste,Pastes,Salve,Unguent,Salves,Skin Ointment,Unguents,Ointment, Skin
D011143 Polyvinyl Chloride A polyvinyl resin used extensively in the manufacture of plastics, including medical devices, tubing, and other packaging. It is also used as a rubber substitute. Chloroethylene Polymer,Polychloroethylene,Vinyl Chloride Polymer,Chloroethylene Homopolymer,Geon,PVC,Ultron,Viaflex,Vinylite,Chloride, Polyvinyl,Homopolymer, Chloroethylene,Polymer, Chloroethylene,Polymer, Vinyl Chloride
D011199 Potentiometry Solution titration in which the end point is read from the electrode-potential variations with the concentrations of potential determining ions. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
D002244 Carbon A nonmetallic element with atomic symbol C, atomic number 6, and atomic weight [12.0096; 12.0116]. It may occur as several different allotropes including DIAMOND; CHARCOAL; and GRAPHITE; and as SOOT from incompletely burned fuel. Carbon-12,Vitreous Carbon,Carbon 12,Carbon, Vitreous
D003915 Dextromethorphan Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (RECEPTORS, N-METHYL-D-ASPARTATE) and acts as a non-competitive channel blocker. It is one of the widely used ANTITUSSIVES, and is also used to study the involvement of glutamate receptors in neurotoxicity. d-Methorphan,Delsym,Dextromethorphan Hydrobromide,Dextromethorphan Hydrobromide, (+-)-Isomer,Dextromethorphan Hydrobromide, Monohydrate,Dextromethorphan Hydrochloride,Dextromethorphan, (+-)-Isomer,Racemethorphan,Hydrobromide, Dextromethorphan,Hydrochloride, Dextromethorphan
D004304 Dosage Forms Completed forms of the pharmaceutical preparation in which prescribed doses of medication are included. They are designed to resist action by gastric fluids, prevent vomiting and nausea, reduce or alleviate the undesirable taste and smells associated with oral administration, achieve a high concentration of drug at target site, or produce a delayed or long-acting drug effect. Dosage Form,Form, Dosage,Forms, Dosage
D004566 Electrodes Electric conductors through which electric currents enter or leave a medium, whether it be an electrolytic solution, solid, molten mass, gas, or vacuum. Anode,Anode Materials,Cathode,Cathode Materials,Anode Material,Anodes,Cathode Material,Cathodes,Electrode,Material, Anode,Material, Cathode
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor
D017022 Flow Injection Analysis The analysis of a chemical substance by inserting a sample into a carrier stream of reagent using a sample injection valve that propels the sample downstream where mixing occurs in a coiled tube, then passes into a flow-through detector and a recorder or other data handling device. Analysis, Flow Injection,Analyses, Flow Injection,Flow Injection Analyses,Injection Analyses, Flow,Injection Analysis, Flow

Related Publications

Elmorsy Khaled, and H N A Hassan, and Gehad G Mohamed, and A A Seleim
Flow injection potentiometric determination of pancuronium bromide in pharmaceutical preparation and urine samples using modified carbon paste electrodes.
January 2011, Chemical & pharmaceutical bulletin,
Elmorsy Khaled, and H N A Hassan, and Gehad G Mohamed, and A A Seleim
PVC membrane, coated-wire, and carbon-paste ion-selective electrodes for potentiometric determination of galantamine hydrobromide in physiological fluids.
August 2018, Materials science & engineering. C, Materials for biological applications,
Elmorsy Khaled, and H N A Hassan, and Gehad G Mohamed, and A A Seleim
Potentiometric determination of ketotifen fumarate in pharmaceutical preparations and urine using carbon paste and PVC membrane selective electrodes.
January 2011, International journal of analytical chemistry,
Elmorsy Khaled, and H N A Hassan, and Gehad G Mohamed, and A A Seleim
Determination of pethidine hydrochloride using potentiometric coated graphite and carbon paste electrodes.
April 2013, Drug testing and analysis,
Elmorsy Khaled, and H N A Hassan, and Gehad G Mohamed, and A A Seleim
Modified carbon paste electrodes for flow injection amperometric determination of isocitrate dehydrogenase activity in serum.
September 2002, Analytical biochemistry,
Elmorsy Khaled, and H N A Hassan, and Gehad G Mohamed, and A A Seleim
Novel PVC-membrane electrode for flow injection potentiometric determination of Biperiden in pharmaceutical preparations.
December 2011, Talanta,
Elmorsy Khaled, and H N A Hassan, and Gehad G Mohamed, and A A Seleim
Flow injection determination of ketotifen fumarate using PVC membrane selective electrodes.
November 2009, Bioelectrochemistry (Amsterdam, Netherlands),
Elmorsy Khaled, and H N A Hassan, and Gehad G Mohamed, and A A Seleim
PVC membrane electrode for the potentiometric determination of Ipratropium bromide using batch and flow injection techniques.
June 2008, Talanta,
Elmorsy Khaled, and H N A Hassan, and Gehad G Mohamed, and A A Seleim
Two fabricated carbon paste electrodes for novel potentiometric determination of probenecid in dosage form and human plasma.
November 2022, Scientific reports,
Elmorsy Khaled, and H N A Hassan, and Gehad G Mohamed, and A A Seleim
Carbon paste- and PVC membrane electrodes as sensitive sensors for the determination of antidiabetic drugs for type 2 diabetic patients.
December 2009, Analytical sciences : the international journal of the Japan Society for Analytical Chemistry,
Copied contents to your clipboard!